Results 1 to 10 of about 14,886,010 (66)

Les narcocorridos du Movimiento Alterado : une poésie de la rue ?

Les Cahiers de Framespa, 2016
This article explores the most recent development of the narcocorrido tradition, the very successful Movimiento Alterado. Mexican-American artists such as El Komander use polka or waltz tunes to describe in violent and explicit words the daily lives of ...
Claude Chastagner
doaj   +1 more source

Regulation of the endosomal SNX27-retromer by OTULIN

Nature Communications, 2019
OTULIN is a linear ubiquitin hydrolase that regulates ubiquitin homeostasis. Here the authors identify the adaptor of the endosomal retromer complex sorting nexin 27 (SNX27) as a binding partner of OTULIN and determine the structure of the OTULIN-SNX27 ...
Aurelia Stangl, Paul R. Elliott, Adan Pinto-Fernandez, Sarah Bonham, Luke Harrison, Annalisa Schaub, Kerstin Kutzner, Kirstin Keusekotten, Paul T. Pfluger, Farid El Oualid, Benedikt M. Kessler, David Komander, Daniel Krappmann   +12 more
doaj   +1 more source

The Landscape of BRCA1‐Associated Post‐Translational Modifications

Cell Biology International, Volume 50, Issue 7, July 2026.
ABSTRACT The BRCA1‐BARD1 complex is a vital protein that promotes homologous recombination, acting through its E3 ubiquitin ligase activity. Although ubiquitination remains its only confirmed enzymatic function, emerging evidence suggests that the complex influences a broad range of post‐translational modifications (PTMs), including methylation ...
Nethma Hewa Waduge, Junhua Xiao, Gregory M. Davis   +2 more
wiley   +1 more source

Redox signals and oxidative stress in the control of mitochondrial protein import

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Mitochondrial protein import is essential for organelle biogenesis and cellular homeostasis. It operates in an environment that is intrinsically shaped by redox chemistry. Mitochondria are major sources of reactive oxygen species (ROS), which arise as by‐products of oxidative phosphorylation. Cells therefore maintain sophisticated ROS‐handling
Lidwina Hasberg, Viktoria Katharina Lauterbach, Torsten Ochsenreiter, Jan Riemer   +3 more
wiley   +1 more source

The E3 Ubiquitin Ligase UBE3B Regulates Synaptic Development and Cortical Network Activity

Autism Research, Volume 19, Issue 5, May 2026.
ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired communication, abnormal social interactions, and restricted, repetitive behaviors. Pathogenic mutations in UBE3B result in neurodevelopmental disease, including intellectual disability, lack of speech, and ASD.
Shayal Vashisth, Aleya Shedd, Ariel Aiken, Solmi Cheon, Josh Bandopadhay, Kiran Kaur, Kimberly M. Huber, Maria H. Chahrour   +7 more
wiley   +1 more source

Advances and opportunities for computational interrogation of plant proteins

The Plant Journal, Volume 126, Issue 3, May 2026.
SUMMARY Plants exhibit remarkable biochemical and physiological diversity, and are capable of adapting to a wide range of environmental conditions and stresses. This complexity makes them essential systems for understanding how life responds to a changing climate.
Sarah M. Bohling, Shaila Musharoff, Laura H. Gunn   +2 more
wiley   +1 more source

Inverse Spillover and Dimensionality Effects on Interstitial Hydrogen

Advanced Materials Interfaces, Volume 12, Issue 23, December 8, 2025.
Interstitial hydrogen behaves distinctly at interfaces compared to the bulk. Vanadium films show proximity‐dependent hydrogen depletion near interfaces–an inverse of hydrogen spillover. Ion beam and resistivity measurements reveal Fe/V‐superlattices have lower hydrogen solubility and higher critical temperature than Cr/V due to proximity‐induced finite
Kristina Komander, Gunnar K. Pálsson, Sotirios A. Droulias, Theofanis Tsakiris, David Sörme, Max Wolff, Daniel Primetzhofer   +6 more
wiley   +1 more source

USP5‐Rich Apoptotic Extracellular Vesicles Regulate Nucleus Pulposus Cells Apoptosis and DNA Damage Repair by Preventing E2F1 Proteasomal Degradation

Journal of Extracellular Vesicles, Volume 14, Issue 8, August 2025.
NPCs of degenerated discs exhibit abnormal subcellular localization of the deubiquitinase USP5, with excessive cytoplasmic retention leading to aberrant ubiquitination and degradation of the nuclear transcription factor E2F1. Following transplantation into the degenerative disc microenvironment, MSCs undergo extensive apoptosis in the short‐term and ...
Pengzhi Shi, Haiyang Gao, Zhangrong Cheng, Wenbo Wu, Anran Zhang, Xianglong Chen, Wang Wu, Yukun Zhang   +7 more
wiley   +1 more source

Mechanistic Insights and Therapeutic Potentials of Ubiquitin‐Proteasome System in Non‐Small Cell Lung Cancer

Cell Proliferation, Volume 58, Issue 7, July 2025.
Lung cancer development involves mechanisms like reduced EGFR/EGF ubiquitination driving cancer cell behaviors and immune evasion via loss of PD‐1/PD‐L1 ubiquitination. Balancing ubiquitination and deubiquitination may be a potential therapeutic strategy. ABSTRACT Non‐small cell lung cancer (NSCLC) remains a leading cause of cancer mortality.
Guangyao Zhou, Jiaxiong Tan, Pengpeng Zhang, Zhaokai Zhou, Lianmin Zhang, Zhenfa Zhang   +5 more
wiley   +1 more source

SEC‐SAXS/MC Ensemble Structural Studies of the Microtubule Binding Protein Cdt1 Show Monomeric, Folded‐Over Conformations

Cytoskeleton, Volume 82, Issue 6, Page 372-387, June 2025.
ABSTRACT Cdt1 is a mixed folded protein critical for DNA replication licensing and it also has a “moonlighting” role at the kinetochore via direct binding to microtubules and the Ndc80 complex. However, it is unknown how the structure and conformations of Cdt1 could allow it to participate in these multiple, unique sets of protein complexes.
Kyle P. Smith, Srinivas Chakravarthy, Amit Rahi, Manas Chakraborty, Kristen M. Vosberg, Marco Tonelli, Maximilian G. Plach, Arabela A. Grigorescu, Joseph E. Curtis, Dileep Varma   +9 more
wiley   +1 more source