Results 251 to 260 of about 126,008 (360)

Naldemedine for the Prevention of Recurrent Acute Pancreatitis: A Randomised, Double‐Blind, Placebo‐Controlled Trial

United European Gastroenterology Journal, Volume 14, Issue 1, February 2026.
ABSTRACT Background and aims No medications are currently approved for the prevention of recurrent acute pancreatitis. This trial evaluated whether naldemedine, a peripherally acting μ‐opioid receptor antagonist, reduces the risk of acute pancreatitis in patients with recurrent acute pancreatitis. Methods This was a multicentre, double‐blinded, placebo‐
Mathias E. Cook, Cecilie S. Knoph, Line Davidsen, Jens B. Frøkjær, Niels H. Bruun, Srdan Novovic, Amer Hadi, Maiken Thyregod Jørgensen, Michael B. Mortensen, Ove Schaffalitzky, Liv B. J. Nielsen, Mark Berner‐Hansen, Asbjørn M. Drewes, Søren S. Olesen   +13 more
wiley   +1 more source

Mild Ozone-Induced Oxidative Stress Modulates the Activity and Viability of Porcine Neutrophils and Monocytes. [PDF]

Animals (Basel)
Nguyen Ngoc D, Valverde Piedra JL, Milczak A, Szponder T, Drzewiecka B, Pyzerska A, Kowalczyk M, Fila M, Tomaszewska E, Ahluwalia A, Wessely-Szponder J.   +10 more
europepmc   +1 more source

Proximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging

Aging Cell, Volume 25, Issue 2, February 2026.
Mouse models revealed age‐associated increased circumferential stiffness of the proximal pulmonary artery that was associated with reorientation of collagen and decreased function of the lung and right ventricle. Age‐related transcriptional changes were indicative of senescence, ECM turnover, TGFβ signaling, and altered intercellular signaling among ...
Ruben De Man, Zhongyu Cai, Pramath Doddaballapur, Nicole Guerrera, Alexandria Regan, Liqin Lin, Erica Schwarz, Aurelien Justet, Nebal S. Abu Hussein, Jack Di Palo, Cristina Cavinato, Micha Sam B. Raredon, Paul M. Heerdt, Inderjit Singh, Xiting Yan, Min‐Jong Kang, Danielle R. Bruns, Patty J. Lee, George Tellides, Jay D. Humphrey, Naftali Kaminski, Abhay B. Ramachandra, Edward P. Manning   +22 more
wiley   +1 more source

Mechanochemical Synthesis of X‐Vinylbenziodoxol(on)es and One‐Pot Conversion to Complex Alkenes**

Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.
The synthesis of a wide range of complex 1,2‐di(heteroatom)‐substituted (Z)‐alkenes is achieved through a mechanochemical one‐pot reaction of ethynylbenziodoxol(on)es (EBX/EBO) with a variety of heteroatom nucleophiles. The mechanochemical activation enables synthesis of a range of novel vinylbenziodoxol(on)es (VBX/VBO) whose synthesis is inefficient ...
Sayad Doobary, Judith Braunreuther, Andrew K. Inge, Berit Olofsson   +3 more
wiley   +2 more sources

FDA approval of brensocatib: a new therapeutic breakthrough in non-cystic fibrosis bronchiectasis. [PDF]

Ann Med Surg (Lond)
Hassan Gardezi SS, Fatima N, Chaudhary U, Irshad M, Fatima M, Gardezi SSEZ.   +5 more
europepmc   +1 more source

Pathomechanismus in Septic Shock [PDF]

, 1986
Duswald, Karl-Heimo, Eitel, F., Fritz, Hans, Inthorn, D., Jochum, Marianne, Schweiberer, L.   +5 more
core  

A Scalable Organoid Model of Urothelial Aging for Metabolic Interrogation, Infection Modeling, and Reversal of Age‐Associated Changes

Aging Cell, Volume 25, Issue 2, February 2026.
mBEDOs: a scalable platform for modeling urothelial aging. mBEDOs derived from aged mouse bladders capture essential molecular and cellular features of urothelial aging and provide a versatile system for high‐throughput metabolic profiling, therapeutic screening via metabolite supplementation, age‐ and sex‐based analyses, infection modeling, and immune–
Adwaita R. Parab, Arnold M. Salazar, Steven J. Bark, Margarita Divenko, Vasanta Putluri, D'Feau J. Lieu, Aadya S. Singh, Nagireddy Putluri, Indira U. Mysorekar   +8 more
wiley   +1 more source

Proinflammatory bone marrow niches and neutrophil activation are associated with TIGIT expression in multiple myeloma. [PDF]

Ann Hematol
Tomarchio V, Arciprete F, Di Cecca M, Maricchiolo G, Velardi V, Tafuri M, Bianchi A, Morano V, Mecorio B, Rigacci L, Crescenzi A, Zingariello M, Annibali O.   +12 more
europepmc   +1 more source

High Fidelity Processing and Activation of the Human α-Defensin HNP1 Precursor by Neutrophil Elastase and Proteinase 3

, 2012
Prasad Tongaonkar, Amir E. Golji, Patti Tran, André J. Ouellette, Michael E. Selsted   +4 more
openalex   +2 more sources

Challenge Specific Modulation of Responses to Adjuvant‐Induced Innate Immune Memory

Immunology, Volume 177, Issue 2, Page 254-269, February 2026.
We utilised a commercially available adjuvant formulation to study the induction, maintenance, and consequences of innate immune memory. Using functional assays on bone marrow‐derived innate cells, extensive transcriptomic analysis of haematopoietic progenitors, and challenge models of spirochetal infection, nonspecific inflammation, and model antigen ...
Samuel T. Pasco, Itziar Martín‐Ruiz, Sarai Araujo‐Aris, Diego Barriales, Janire Castelo, Leire Egia‐Mendikute, Monika Gonzalez, Jose Ezequiel Martin, Elena Molina, Maitane Mugica, Ainhoa Palacios, Iratxe Seoane, Naiara Gutiez, Estibaliz Atondo, Eneko Santos Fernández, Maddi Oyanguren, Borja Jimenez‐Lasheras, Ainize Peña‐Cearra, Ana M. Aransay, Asis Palazon, Aize Pellón, Leticia Abecia, Hector Rodriguez, Natalia Elguezabal, Juan Anguita   +24 more
wiley   +1 more source