Results 301 to 310 of about 87,970 (343)
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Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice.
Science, 1997To determine which proteinases are responsible for the lung destruction characteristic of pulmonary emphysema, macrophage elastase-deficient (MME-/-) mice were subjected to cigarette smoke.
R. Hautamaki +3 more
semanticscholar +1 more source
Elastase activity: The role of elastase in aortic aneurysm formation
Journal of Surgical Research, 1982Abstract Elastase activity was studied in aortic tissue obtained from patients with aortic aneurysm and arteriosclerotic occlusive disease. Aneurysmal tissue demonstrates significantly greater activity than the arteriosclerotic aorta and the activity is localized to the intima and inner media.
Cecil Carmack +7 more
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The induction of pulmonary emphysema with human leukocyte elastase.
American Review of Respiratory Disease, 2015Purified human leukocyte elastase was injected into the tracheas of 46 hamsters. Thirteen animals died spontaneously within 1 week, with extensive lung hemorrhage.
R. Senior +5 more
semanticscholar +1 more source
American Review of Respiratory Disease, 2015
Human neutrophilic polymorphonuclear leukocyte (PMN) elastase was purified by affinity chromatography to greater than 95% homogeneity as judged by disc-gel electrophoresis.
A. Janoff +6 more
semanticscholar +1 more source
Human neutrophilic polymorphonuclear leukocyte (PMN) elastase was purified by affinity chromatography to greater than 95% homogeneity as judged by disc-gel electrophoresis.
A. Janoff +6 more
semanticscholar +1 more source
Synthetic Inhibitors of Elastase
Medicinal Research Reviews, 1994For more than two decades investigators around the world, in both academic and industrial institutions, have been developing inhibitors of human neutrophil elastase. A number of very elegant and insightful strategies have been reported. In the case of reversible peptidic inhibitors, this has resulted in the identification of some extremely potent ...
Philip D. Edwards, Peter R. Bernstein
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Radiation Research, 1975
The γ-radiolysis of elastase caused exponential losses of elastinolytic activity, although losses of esterolytic ability followed nonexponential relations. The nature of the damage to component residues of the enzyme varied depending on the reactive radical species, but trp and tyr were extensively damaged under all circumstances studied.
K. R. Lynn, W. J. Skinner
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The γ-radiolysis of elastase caused exponential losses of elastinolytic activity, although losses of esterolytic ability followed nonexponential relations. The nature of the damage to component residues of the enzyme varied depending on the reactive radical species, but trp and tyr were extensively damaged under all circumstances studied.
K. R. Lynn, W. J. Skinner
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Neonatal lung neutrophils and elastase/proteinase inhibitor imbalance.
American Review of Respiratory Disease, 2015Serial bronchoalveolar lavage (BAL) was performed prospectively on 10 normal control subjects, 20 Respiratory Distress Syndrome (RDS), and 11 Bronchopulmonary Dysplasia (BPD) newborn infants to evaluate the role of pulmonary inflammation in neonatal lung
B. Ogden +4 more
semanticscholar +1 more source
On the specificity of porcine elastase
Biochimica et Biophysica Acta (BBA) - Enzymology, 1975The specificity of porcine elastase (EC 3.4.4.7) has been studied. Ethyl esters derived from benzoyl amino acids with straight side chains are better substrates than those with branched side chains; the best substrate is norvaline ester. In the series of benzoylalanine alkyl esters the alcohol moiety markedly affects the susceptibility.
Rivka Gold, Yechiel Shalitin
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The role of tyrosines in elastase
Archives of Biochemistry and Biophysics, 1972Abstract The conformational behavior of elastase between pH 7 and 11 has been investigated, with particular emphasis on tyrosine residues. Of these, ten titrate normally and one is totally inaccessible to ionization. On the basis of chemical modification, the eleven tyrosines can be subdivided into three reactive classes and one totally unreactive ...
Marina J. Gorbunoff, Serge N. Timasheff
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Neutrophil elastase and cancer
Surgical Oncology, 2006This mini-review summarizes our recent experimental and clinical studies on neutrophil elastase (NE) and cancer based on our original view point. Neoplasms metastasize as a result of a complex series of events. This process requires various degradative enzymes including proteases.
Miwa Akizuki +7 more
openaire +3 more sources