Results 51 to 60 of about 874,200 (294)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Hollow core photonic bandgap fibers for telecommunications: opportunities and potential issues [PDF]

, 2012
We discuss the potential advantages that hollow core photonic bandgap fibers may ultimately have over conventional all solid fibers and review the state-of-the-art, fundamental physical limits and the many technological challenges to be ...
Petrovich, M.N., Baddela, N., Richardson, D.J., Wheeler, N.V., Poletti, F., Numkam Fokoua, Eric, Hayes, J.R.   +6 more
core   +2 more sources

Elastic fiber ultrastructure and assembly

Matrix Biology, 2019
Studies over the years have described a filamentous structure to mature elastin that suggests a complicated packing arrangement of tropoelastin subunits. The currently accepted mechanism for tropoelastin assembly requires microfibrils to serve as a physical extracellular scaffold for alignment of tropoelastin monomers during and before crosslinking ...
Beth A, Kozel, Robert P, Mecham
openaire   +3 more sources

Modeling large air fraction holey optical fibers [PDF]

, 2000
We develop a modal decomposition approach to solve the full vector wave equation for holey optical fibers (HF). This model can be used to explore the modal properties of a wide range of HFs, including those with large air holes. The optical properties of
Bennett, P.J., Richardson, D.J., Broderick, N.G.R., Monro, T.M.   +3 more
core   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

A Numerical–Experimental Approach for Multi‐Matrix Fiber‐Reinforced Plastics Characterization Using Finite Element Model Updating

Advanced Engineering Materials, EarlyView.
A numerical–experimental framework is developed for characterizing multi‐matrix fiber‐reinforced polymers (MM‐FRPs) combining epoxy and polyurethane matrices. Harmonic bending tests are integrated with finite element model updating (FEMU) to simultaneously identify elastic and viscoelastic material parameters.
Rodrigo M. Dartora, Tales V. Lisbôa, Axel Spickenheuer, Rogério J. Marczak, Jakson M. Vassoler   +4 more
wiley   +1 more source

Unraveling Elastic Fiber-Derived Signaling in Arterial Aging and Related Arterial Diseases

Biomolecules
Arterial stiffening is a significant risk factor for the development of cardiovascular diseases, including hypertension, atherosclerosis, and arteriopathy.
Mingyi Wang, Kimberly R. McGraw, Robert E. Monticone, Gianfranco Pintus   +3 more
doaj   +1 more source

Qualitative and quantitative characterization of the Rhesus monkey (Macaca mulatta) penis [PDF]

International Brazilian Journal of Urology
Background: Knowledge of the anatomy of laboratory animals is important for experimental research. Erectile dysfunction has been studied using the penises of different laboratory animals such as rats, mice, rabbits, dogs, etc. However, these animals have
Marcelo Abidu-Figueiredo, Edilaine F. Alves, Carla B. M. Gallo, Waldemar S. Costa, Luciano A. Favorito, Francisco J. B. Sampaio   +5 more
doaj   +1 more source

Energy harvesting from sonic noises by phononic crystal fibers

Scientific Reports, 2022
In this investigation, a phononic crystal-based fiber is proposed for energy harvesting application in metalworking factories. Phononic crystal plays the role of cladding in elastic fiber structure.
Farzaneh Motaei, Ali Bahrami
doaj   +1 more source