Results 31 to 40 of about 6,455 (264)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

Nonlinear dynamic response of ES-FGM plate under blast load

open access: yesVietnam Journal of Mechanics, 2018
The paper studies nonlinear dynamic response of an eccentrically stiffened FGM (ES-FGM) plates resting on the elastic foundations subjected to blast and thermal loads with temperature dependent material properties using the Reddy's higher order shear ...
Pham Hong Cong, Nguyen Dinh Duc
doaj   +1 more source

Two Novel Vlasov Models for Bending Analysis of Finite-Length Beams Embedded in Elastic Foundations

open access: yesBuildings, 2022
The issue of soil–structure interaction (SSI) is essentially to analyze the influence of complex media on the mechanical behavior of supported structures.
Feng Yue   +3 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Non-linear dynamic response and vibration of an imperfect three-phase laminated nanocomposite cylindrical panel resting on elastic foundations in thermal environments

open access: yesScience and Engineering of Composite Materials, 2017
This paper presents an analytical approach to investigate the non-linear dynamic response and vibration of an imperfect three-phase laminated nanocomposite cylindrical panel resting on elastic foundations in thermal environments.
Thu Pham Van, Duc Nguyen Dinh
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

Analysis of Beams on Non-Linear Elastic Winkler Foundation [PDF]

open access: yesEngineering and Technology Journal, 2005
This paper deals with thin beams resting on non-linear Winkler foundations by using the secant modulus approach to specify the modulus of subgrade reaction.
Mustafa Al-Ani
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

open access: yesFEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss   +7 more
wiley   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach   +23 more
wiley   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit   +11 more
wiley   +1 more source

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