Results 41 to 50 of about 1,032,409 (288)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Analysis of Beams on Non-Linear Elastic Winkler Foundation [PDF]

open access: yesEngineering and Technology Journal, 2005
This paper deals with thin beams resting on non-linear Winkler foundations by using the secant modulus approach to specify the modulus of subgrade reaction.
Mustafa Al-Ani
doaj   +1 more source

Two Novel Vlasov Models for Bending Analysis of Finite-Length Beams Embedded in Elastic Foundations

open access: yesBuildings, 2022
The issue of soil–structure interaction (SSI) is essentially to analyze the influence of complex media on the mechanical behavior of supported structures.
Feng Yue   +3 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

open access: yesFEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss   +7 more
wiley   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

open access: yesFEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang   +10 more
wiley   +1 more source

On large bending deformations of transversely isotropic rectangular elastic blocks [PDF]

open access: yes, 2007
In this paper we examine the classical problem of finite bending of a rectangular block of elastic material into a sector of a circular cylindrical tube in respect of compressible transversely isotropic elastic materials.
Kassianidis , Fotios   +3 more
core   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

open access: yesFEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo   +4 more
wiley   +1 more source

Beams on Elastic Foundation. The Simplified Continuum Approach

open access: yesBulletin of the Polytechnic Institute of Jassy: Constructions, Architechture Section, 2009
The key aspect in the design of flexible structural elements in contact with bearing soils is the way in which soil reaction, referred to qualitatively as soil’s reactive pressure (p), is assumed or accounted for in analysis. A magnitude and distribution
Iancu-Bogdan Teodoru
doaj  

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach   +23 more
wiley   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit   +11 more
wiley   +1 more source

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