Results 51 to 60 of about 57,263 (295)

The combination of supervised and unsupervised learning based risk stratification and phenotyping in pulmonary arterial hypertension—a long-term retrospective multicenter trial

BMC Pulmonary Medicine, 2023
Background Accurate risk stratification in pulmonary arterial hypertension (PAH), a devastating cardiopulmonary disease, is essential to guide successful therapy.
Thomas Sonnweber, Piotr Tymoszuk, Regina Steringer-Mascherbauer, Elisabeth Sigmund, Stephanie Porod-Schneiderbauer, Lisa Kohlbacher, Igor Theurl, Irene Lang, Günter Weiss, Judith Löffler-Ragg   +9 more
doaj   +1 more source

Improved Prediction of Bacterial Genotype-Phenotype Associations Using Interpretable Pangenome-Spanning Regressions

mBio, 2020
Discovery of genetic variants underlying bacterial phenotypes and the prediction of phenotypes such as antibiotic resistance are fundamental tasks in bacterial genomics.
John A. Lees, T. Tien Mai, Marco Galardini, Nicole E. Wheeler, Samuel T. Horsfield, Julian Parkhill, Jukka Corander   +6 more
doaj   +1 more source

Learned elastic net coefficients and feature types. [PDF]

, 2018
Learned elastic net coefficients and feature types.
Lester Mackey (6166916), Mark D. M. Leiserson (414930), Dean F. Bajorin (4050298), Vasilis Syrgkanis (6166901), Miroslav Dudik (6166904), Sharon Gillett (6166907), Amy Gilson (3170658), Christian Borgs (5712371), Jennifer Chayes (6166910), Jonathan E. Rosenberg (607309), Samuel Funt (6166913), Alexandra Snyder (349605)   +11 more
core   +1 more source

PERFORMANCE OF LASSO AND ELASTIC-NET METHODS ON NON-INVASIVE BLOOD GLUCOSE MEASUREMENT CALIBRATION MODELING

Barekeng, 2023
Diabetes Mellitus (DM) is a disease that can occur in humans caused by conditions of high blood glucose levels (hyperglycemia). Detection of blood glucose levels can be done using invasive methods (injuring) and non- invasive methods (with infrared rays).
Farah Abqorunnisa, Erfiani Erfiani, Anik Djuraidah   +2 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Spatially regularized estimation for the analysis of DCE-MRI data [PDF]

, 2012
Competing compartment models of different complexities have been used for the quantitative analysis of Dynamic Contrast-Enhanced Magnetic Resonance Imaging data.
Gertheiss, Jan, Schmid, Volker J., Sommer, Julia C.   +2 more
core   +1 more source

Elastic SCAD as a novel penalization method for SVM classification tasks in high-dimensional data

BMC Bioinformatics, 2011
Background Classification and variable selection play an important role in knowledge discovery in high-dimensional data. Although Support Vector Machine (SVM) algorithms are among the most powerful classification and prediction methods with a wide range ...
Lichter Peter, Toedt Grischa, Becker Natalia, Benner Axel   +3 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Multinomial Regression with Elastic Net Penalty and Its Grouping Effect in Gene Selection

Abstract and Applied Analysis, 2014
For the multiclass classification problem of microarray data, a new optimization model named multinomial regression with the elastic net penalty was proposed in this paper.
Liuyuan Chen, Jie Yang, Juntao Li, Xiaoyu Wang   +3 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source