Results 61 to 70 of about 49,678 (264)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Ridge Regression and the Elastic Net: How Do They Do as Finders of True Regressors and Their Coefficients?

Mathematics, 2022
For the linear model Y=Xb+error, where the number of regressors (p) exceeds the number of observations (n), the Elastic Net (EN) was proposed, in 2005, to estimate b.
Rajaram Gana
doaj   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Zero-Inflated Binary Classification Model with Elastic Net Regularization

Mathematics
Zero inflation and overfitting can reduce the accuracy rate of using machine learning models for characterizing binary data sets. A zero-inflated Bernoulli (ZIBer) model can be the right model to characterize zero-inflated binary data sets.
Hua Xin, Yuhlong Lio, Hsien-Ching Chen, Tzong-Ru Tsai   +3 more
doaj   +1 more source

Degradation Pattern Identification and Remaining Useful Life Prediction for Mechanical Equipment Using SKF-EN

IEEE Access, 2020
Due to the influence of working environment and stress, the failure degradation process of mechanical equipment is characterized by non-stationarity and uncertainty. The degradation pattern of a large number of mechanical equipment obeys the process from
Shenglong Wang, Bo Jing, Xiaoxuan Jiao, Jinxin Pan   +3 more
doaj   +1 more source

Hyperspectral estimation of chlorophyll content in jujube leaves: integration of derivative processing techniques and dimensionality reduction algorithms

Frontiers in Plant Science, 2023
The leaf chlorophyll content (LCC) of vegetation is closely related to photosynthetic efficiency and biological activity. Jujube (Ziziphus jujuba Mill.) is a traditional economic forest tree species.
Nigela Tuerxun, Nigela Tuerxun, Jianghua Zheng, Jianghua Zheng, Renjun Wang, Renjun Wang, Lei Wang, Liang Liu, Liang Liu   +8 more
doaj   +1 more source

Learning performance of elastic-net regularization

Mathematical and Computer Modelling, 2013
In this paper, within the framework of statistical learning theory we address the elastic-net regularization problem. Based on the capacity assumption of hypothesis space composed by infinite features, significant contributions are made in several aspects.
Yu-long Zhao, Yun-Long Feng
openaire   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

DNA Methylation-Based Panel Predicts Survival of Patients With Clear Cell Renal Cell Carcinoma and Its Correlations With Genomic Metrics and Tumor Immune Cell Infiltration

Frontiers in Cell and Developmental Biology, 2020
DNA methylation based prognostic factor for patients with clear cell renal cell carcinoma (ccRCC) remains unclear. In the present study, we identified survival-related DNA methylation sites based on the differentially methylated DNA CpG sites between ...
Xiao-Ping Liu, Lingao Ju, Lingao Ju, Chen Chen, Chen Chen, Tongzu Liu, Sheng Li, Sheng Li, Xinghuan Wang   +8 more
doaj   +1 more source

Gut microbiota landscape and potential biomarker identification in female patients with systemic lupus erythematosus using machine learning

Frontiers in Cellular and Infection Microbiology, 2023
ObjectivesSystemic Lupus Erythematosus (SLE) is a complex autoimmune disease that disproportionately affects women. Early diagnosis and prevention are crucial for women’s health, and the gut microbiota has been found to be strongly associated with SLE ...
Wenzhu Song, Feng Wu, Yan Yan, Yaheng Li, Qian Wang, Xueli Hu, Yafeng Li, Yafeng Li, Yafeng Li, Yafeng Li   +9 more
doaj   +1 more source