Elastin-like polypeptide - Open Access .click

Advanced Drug Delivery Reviews, 2022
Cytokines are a group of pleiotropic proteins which are crucial for various biological processes and useful as therapeutics. However, they usually suffer from the poor stability, extreme short circulation half-life, difficulty in high-yield and large-scale production and side effects, which greatly restricts their applications.
Like, Gong +3 more
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Genetically Encoded Elastin‐Like Polypeptides for Drug Delivery

Advanced Healthcare Materials, 2021
AbstractElastin‐like polypeptides (ELPs) are thermally responsive biopolymers that consist of a repeated amino acid motif derived from human tropoelastin. These peptides exhibit temperature‐dependent phase behavior that can be harnessed to produce stimuli‐responsive biomaterials, such as nanoparticles or injectable drug delivery depots.
Irene C. Jenkins, Joshua J. Milligan, Ashutosh Chilkoti +2 more
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Recombination and Purification of Elastin-Like Polypeptides

2021
Elastin, as an extracellular matrix protein, has inherent advantages for biomedical applications. For example, it is highly extensible and biocompatible, biodegradable, and has no immunogenicity. However, directly extracting elastin from biological tissues remains challenging because they usually coexist with other proteins such as collagen. Therefore,
Chenxi, Zhao +4 more
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Self-assembled elastin-like polypeptide particles

Acta Biomaterialia, 2008
In this work, the self-assembly of a recombinant elastin-based block copolymer containing both hydrophobic and cross-linking domains from the human elastin protein was investigated. The particle formation and dynamic behavior were characterized using inverted microscopy and dynamic light scattering.
Jill L, Osborne, Robin, Farmer, Kimberly A, Woodhouse +2 more
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elastin
chemistry
biology

peptides
biochemistry
medicine

materials science
genetics
3. good health