Results 211 to 220 of about 14,114 (244)

Spectroscopic studies on elastin-like synthetic polypeptides

International Journal of Biological Macromolecules, 1990
Spectroscopic studies on synthetic polypeptides containing the unit-X-G-G (X=V or L) are reported. The sequences, constituting either fragments or model of elastin, were shown to adopt type II beta-turns together with an ensemble of unordered conformations.
M. A. CASTIGLIONE MORELLI, A. SCOPA, A. M. TAMBURRO, GUANTIERI, Valeria   +3 more
openaire   +4 more sources

Catechol-Functionalized Elastin-like Polypeptides as Tissue Adhesives

Biomacromolecules, 2020
Adhesives can potentially be used to achieve fast and efficient wound closure; however, current products show poor bonding on wet surfaces, undergo swelling, and lack adequate biocompatibility. We designed a hydrogel adhesive with recombinant elastin-like polypeptides (ELPs), which are flexible proteins that can be customized for biomedical needs.
Malav S. Desai, Min Chen, Farn Hing Julio Hong, Ju Hun Lee, Yaojiong Wu, Seung-Wuk Lee   +5 more
openaire   +2 more sources

Epitope tagging for tracking elastin-like polypeptides

Biomaterials, 2006
Elastin-like polypeptides (ELPs) are a class of biocompatible, non-immunogenic and crosslinkable biomaterials that offer promise for use as an injectable scaffold for cartilage repair. In this study, an oligohistidine (His(6)) epitope tag was incorporated at the N-terminus of an ELP using recombinant DNA techniques to permit tracking without ...
Shin R, Ong, Kimberly A, Trabbic-Carlson, Dana L, Nettles, Dong W, Lim, Ashutosh, Chilkoti, Lori A, Setton   +5 more
openaire   +2 more sources

Emerging Role of Elastin-Like Polypeptides in Regenerative Medicine

Advances in Wound Care, 2021
Significance: Wound dressing based on naturally derived polymer provides a useful platform for treatment of skin injuries. Owing to the high mechanical strength and tunable structural and physicochemical properties of human elastin-like polypeptides (ELPs), they may be used as excellent materials for fabricating biocompatible scaffolds and other ...
Vijaya, Sarangthem, Thoudam Debraj, Singh, Amit Kumar, Dinda   +2 more
openaire   +2 more sources

Graphene-Based Materials Functionalized with Elastin-like Polypeptides

Langmuir, 2014
Graphene-based materials commonly require functionalization for biological applications in order to control their physical/colloidal properties and to introduce additional capabilities, such as stimuli-responsiveness and affinity to specific biomolecules.
Eddie, Wang, Malav S, Desai, Kwang, Heo, Seung-Wuk, Lee   +3 more
openaire   +2 more sources

Elastin‐like polypeptides: Biomedical applications of tunable biopolymers

Peptide Science, 2010
AbstractArtificial repetitive polypeptides have grown in popularity as a bioinspired alternative to synthetic polymers. The genetically encoded synthesis, monodispersity, potential lack of toxicity, and biocompatibility are attractive features of these biopolymers for biological applications.
Sarah R, MacEwan, Ashutosh, Chilkoti
openaire   +2 more sources

Genetically encoded elastin-like polypeptide nanoparticles for drug delivery

Current Opinion in Biotechnology, 2022
Small molecule drugs suffer from poor in vivo half-life, rapid degradation, and systemic off-target toxicity. To address these issues, researchers have developed nanoparticles that significantly enhance the delivery of many drugs while reducing their toxicity and improving targeting to specific organs.
Joshua J Milligan, Soumen Saha, Irene C Jenkins, Ashutosh Chilkoti   +3 more
openaire   +2 more sources

Thermoswitchable Nanoparticles Based on Elastin-like Polypeptides

Macromolecules, 2015
The design of biocompatible particles with defined size on the nanometer scale has proven to be a challenging task in current biomedical research. Here we present an approach toward temperature-responsive nanoparticles by covalently cross-linking micelles based on trimeric constructs of elastin-like polypeptides.
Kracke, Bettina, Cole, James T., Kaiser, Christoph J. O., Hellenkamp, Björn, Krysiak, Stefanie, Ghoorchian, Ali, Braun, Gary B., Holland, Nolan B., Hugel, Thorsten   +8 more
openaire   +2 more sources

Elastin‐like polypeptides: A strategic fusion partner for biologics

Biotechnology and Bioengineering, 2016
ABSTRACTElastin‐like peptides (ELPs) are derivatives of tropoelastin with a unique property that allows them to stay soluble below a certain critical temperature but reversibly form aggregates above that temperature. Since they are derived from tropoelastin, ELPs are biocompatible, non‐toxic, and non‐immunogenic. The unique properties of ELPs have made
Agnes, Yeboah, Rick I, Cohen, Charles, Rabolli, Martin L, Yarmush, Francois, Berthiaume   +4 more
openaire   +2 more sources

Protease-Driven Phase Separation of Elastin-Like Polypeptides

Biomacromolecules
Elastin-like polypeptides (ELPs) are a promising material platform for engineering stimuli-responsive biomaterials, as ELPs undergo phase separation above a tunable transition temperature. ELPs with phase behavior that is isothermally regulated by biological stimuli remain attractive for applications in biological systems.
Brendan M. Wirtz, Allison G. Yun, Chloe Wick, Xiaojing J. Gao, Danielle J. Mai   +4 more
openaire   +2 more sources