Results 131 to 140 of about 111,880 (336)

Lipid Indices, Elastin Turnover and the Development of Microvascular Complications – A Study in Diabetic Patients with Arterial Hypertension

open access: yesActa Medica Bulgarica, 2019
Background and Aims: An important factor in the development of vascular wall lesions is the degradation of the elastic fiber major protein – elastin. Elastin peptides (EDP) derived from this degradation are present in the circulation and are a stimulus ...
Nikolov A.   +4 more
doaj   +1 more source

In Situ Graph Reasoning and Knowledge Expansion Using Graph‐PRefLexOR

open access: yesAdvanced Intelligent Discovery, EarlyView.
Graph‐PRefLexOR is a novel framework that enhances language models with in situ graph reasoning, symbolic abstraction, and recursive refinement. By integrating graph‐based representations into generative tasks, the approach enables interpretable, multistep reasoning.
Markus J. Buehler
wiley   +1 more source

AI‐Driven Microphysiological Systems for Advancing Nanoparticle Therapeutics

open access: yesAdvanced Intelligent Systems, EarlyView.
This review outlines recent advances in integrating artificial intelligence with microphysiological systems for nanoparticle evaluation. It highlights data‐driven optimization, image‐based prediction, and AI‐enabled analysis frameworks that advance translational research and support the development of personalized nanomedicine. Nanoparticles (NPs) play
Yedam Lee   +3 more
wiley   +1 more source

Presenilin-1 in smooth muscle cells facilitates hypermuscularization in elastin aortopathy

open access: yesiScience
Summary: Smooth muscle cell (SMC) accumulation is central to the pathogenesis of elastin-defective arterial diseases, including supravalvular aortic stenosis (SVAS).
Junichi Saito   +3 more
doaj  

Management of Cardiovascular Health Issues in Turner Syndrome: Expert Insights and Expanded Recommendations From the 2024 Guideline Development Team

open access: yesAmerican Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Turner syndrome (TS) is frequently complicated by congenital heart disease (CHD). While left‐sided lesions such as bicuspid aortic valve (BAV) and coarctation of the aorta are the most common structural heart lesions in TS, other anomalies, such as aortic arch malformations, hypoplastic left heart syndrome (HLHS), persistent left superior vena
Katya de Groote   +9 more
wiley   +1 more source

Influence of the arterial elastic component on the response to balloon angioplasty in femoral arteries of a healthy porcine model

open access: yesAnimal Models and Experimental Medicine, EarlyView.
This study evaluates the role of elastin in vascular response 28 days after balloon angioplasty using uncoated and paclitaxel‐coated balloons in a healthy porcine model. The results show higher elastin content in external femoral arteries, which is inversely correlated with vascular injury, inflammation, smooth muscle cell loss, proteoglycan and fibrin
María Gracia de Garnica García   +7 more
wiley   +1 more source

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