Results 151 to 160 of about 111,358 (307)

Dual‐Crosslinked Hydrogels With Enhanced Mechanical and Thermal Properties

Journal of Polymer Science, EarlyView.
An illustrative depiction of a dual‐crosslinked polymer network achieved with dynamic crosslinkers (blue) and covalent crosslinkers (red). ABSTRACT Creating artificial skin requires materials that can mimic the mechanical properties and structural integrity of natural skin.
Lilian Boton, Brett Leslie Pollard, Luke A. Connal   +2 more
wiley   +1 more source

Novel Therapeutics for Chronic Obstructive Pulmonary Disease: From Empirical Bronchodilation to Precision Medicine

Respirology, EarlyView.
ABSTRACT Chronic obstructive pulmonary disease (COPD) remains the third leading cause of death worldwide, and conventional bronchodilator‐based therapies have limited efficacy in preventing exacerbations and disease progression. The 2024–2026 period represents a historic inflection point: three mechanistically distinct agents received Food and Drug ...
Naoya Fujino, Hisatoshi Sugiura
wiley   +1 more source

Combined Transcriptomic and Proteomic Forecast Analyses for Potential Biomarkers of Smoking‐Induced Benign and Malignant Transformation of Vocal Fold Lesions

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective Laryngeal dysplasia and Reinke's edema (RE) are common vocal fold lesions associated with smoking. While the former is cancer prone, most cases of the latter do not undergo malignant transformation. Therefore, we proposed identifying biomarkers of smoking‐induced benign‐malignant transformation of vocal fold lesions.
Yun‐Yi Liu, Pei‐Yun Zhuang
wiley   +1 more source

In Vitro and In Vivo Evaluation of Decellularized Porcine Femoral Aorta Reinforced With Electrospun Coarse Polycaprolactone Fibers for Vascular Graft Application

Artificial Organs, EarlyView.
This study aims to develop a hybrid small‐diameter vascular graft by combining electrospun PCL with decellularized porcine femoral aorta (PECM). The graft showed complete decellularization, strong mechanical integrity, and no layer delamination.
Hyun‐Yong Lee, Md. Abdullah Al Fahad, Myeongki Park, Hoe‐Jin Kang, Nusrat Jahan, Prayas Chakma Shanto, Hyeyoung Kim, Byong‐Taek Lee, Sang Ho Bae   +8 more
wiley   +1 more source

Cytochrome P450 1A1 influences obesity‐induced pulmonary hypertension

British Journal of Pharmacology, EarlyView.
Background and Purpose The contribution of obesity to pulmonary arterial hypertension (PAH) pathophysiology remains poorly understood. Adipose tissue synthesises estrogens via cytochrome P450 (CYP) 19A1 (aromatase), whereas circulating estrogens are metabolised in the lung by CYP1A1.
Joshua P. Dignam, Smriti Sharma, Gregor Aitchison, Ayman Gebril, Ioannis Stasinopoulos, Sofia Laforest, Chelbi Coyle, Ruth Andrew, Natalie Z. M. Homer, Sébastien Bonnet, Sandra Breuils‐Bonnet, Martin Wabitsch, Margaret R. MacLean   +12 more
wiley   +1 more source

Decoding elastin-collagen resemblance in keloid scar through label-free imaging and machine learning. [PDF]

J Biomed Opt
Wang C, Meng J, Zhou L, Chen L, Qian S, Jiang R, Chen C, Yang L, Chen L, Zhou W, Ding Z, Zhuo S, Liu Z.   +12 more
europepmc   +1 more source

Elastin [PDF]

, 2020
openaire   +1 more source

β3‐adrenoceptor agonism exerts lung protection in a rat model of bronchopulmonary dysplasia

British Journal of Pharmacology, EarlyView.
The β3‐adrenoceptors agonist BRL37344 promotes lung maturation, preventing the progression of experimental bronchopulmonary dysplasia. Absract Background and Purpose Bronchopulmonary dysplasia (BPD) affects premature newborns, particularly those receiving supplemental oxygen therapy.
Alessandro Pini, Patrizia Nardini, Virginia Zizi, Marta Molino, Maura Calvani, Francesco Carrozzo, Rachele Amato, Daniele Guasti, Denise Biagini, Fabio di Francesco, Ludovico Silvestri, Alessandra Franceschini, Daniele Bani, Elisa Imbimbo, Luca Filippi   +14 more
wiley   +1 more source

Distinct hyaluronan content and hierarchical organization of collagen-elastic fiber assemblies in subcutaneous fascia. [PDF]

Biochem Biophys Rep
Maeda N, Togashi K, Shin Y, Imamura Y.
europepmc   +1 more source

Thrombospondin‐4 is upregulated in abdominal aortic aneurysm: A vasoprotective response with potential therapeutic relevance

British Journal of Pharmacology, EarlyView.
TSP4 is upregulated in human and experimental AAA. TSP4 knockdown accelerated AAA formation and exacerbated both vascular inflammation and remodelling, emphasizing that TSP4 upregulation may represent a protective response against AAA. Our findings suggest that preserving TSP4 could be a useful strategy in the clinical management of AAA.
Laia Blanco‐Casoliva, Lidia Puertas‐Umbert, Judith Alonso, Rafael Almendra‐Pegueros, Saray Varona, Mercedes Camacho, Gemma Arderiu, Lluís Asmarats, Marta Alegret, Jose Martinez‐Gonzalez, Cristina Rodriguez   +10 more
wiley   +1 more source