Experimental Physiology, EarlyView.Abstract Central arterial stiffening, particularly of the proximal aorta, is increasingly recognised as a pivotal contributor to cardiovascular disease, dementia, and mild cognitive impairment. Loss of Windkessel function amplifies pulsatile pressure, reduces diastolic perfusion and accelerates microvascular damage in the brain.
Jun Sugawara, Hirofumi Tanaka
wiley +1 more source
Beyond the tear: the enduring role of aortic pathology in the era of genomic medicine. [PDF]
Open HeartGrewal N, Niessen HWM.
europepmc +1 more source
Contributions of vascular ageing to late‐onset Alzheimer's disease
Experimental Physiology, EarlyView.Abstract Late‐onset Alzheimer's disease (LOAD) is an age‐related disease that is strongly associated with vascular risk factors and cerebrovascular impairments. As such, changes in the vasculature with advancing age likely contribute to LOAD, but the mechanisms underlying these contributions remain incompletely understood.
Skylyn J. Ferguson +2 more
wiley +1 more source
Evaluation of the vascular remodeling markers elastin, vascular endothelial growth factor A (VEGF-A), vascular endothelial growth factor receptor 2 (VEGFR2), and nitric oxide in patients with varicose veins. [PDF]
Kardiochir Torakochirurgia PolShaalan SH, Auda FM.
europepmc +1 more source
Lower cerebral blood flow but not cerebrovascular response in elastin haploinsufficient mice
Experimental Physiology, EarlyView.Abstract Elastin insufficiency is associated with structural differences in the large elastic arteries and cerebral artery dysfunction. However, previous studies have not assessed potential sex differences in cerebrovascular function. We measured cerebral blood flow (CBF) using arterial spin labeling MRI at rest and in response to hypercapnia challenge
Abigail E. Cullen +15 more
wiley +1 more source
Disparate Mechanical and Functional Properties of Spontaneously Hypertensive Rat and Spontaneously Hypertensive Heart Failure Rat Penetrating Arterioles. [PDF]
J Cardiovasc PharmacolAcosta C, Anderson HD, Anderson CM.
europepmc +1 more source
Experimental Physiology, EarlyView.Abstract Advanced age is the strongest risk factor for Alzheimer's disease and related dementias (ADRDs). Traumatic brain injury (TBI) has also been recognized as a risk factor for ADRD, potentially contributing to an earlier onset of the disease. Thus, elucidating the mechanisms underlying brain ageing and TBI is critical for developing strategies to ...
Tsubasa Tomoto +3 more
wiley +1 more source
Preclinical HistoBench: A Pilot Benchmark Dataset for Evaluating Large Language Models on Preclinical Histopathological Classification. [PDF]
Biology (Basel)Kader A +6 more
europepmc +1 more source
Computational analysis to assess hemodynamic forces in descending thoracic aortic aneurysms
The Journal of Physiology, EarlyView.Abstract figure legend Left: Pre‐processing. First, we perform the segmentation of the Computer Tomography angiorgraphy (angio‐CT) scans of a healthy patient, obtaining the surface of a healthy thoracic aorta with a Type III aortic arch. Then, we build nine ideal configurations with Descending Thoracic Aortic Aneurysm (DTAA), varying the aortic arch ...
Francesca Duca +7 more
wiley +1 more source
Biochemical and mechanical effects of biopreservation methods on decellularized porcine skin grafts. [PDF]
BMC Res NotesBrooks CM +3 more
europepmc +1 more source