Results 81 to 90 of about 101,796 (243)

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

Chemistry &Biodiversity, EarlyView.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves, Giulia Cristina de Andreoli Souza, Alvaro Jose Hernandez Tasco, Marcos José Salvador   +3 more
wiley   +1 more source

Role of elastin anisotropy in structural strain energy functions of arterial tissue [PDF]

, 2018
The vascular wall exhibits nonlinear anisotropic mechanical properties. The identification of a strain energy function (SEF) is the preferred method to describe its complex nonlinear elastic properties. Earlier constituent-based SEF models, where elastin
Fonck, E., Genoud, C., Rezakhaniha, R., Stergiopulos, N.   +3 more
core  

Mammalian Tolerance to Amino Acid Heterochirality

ChemBioChem, Accepted Article.
Organisms use amino acids predominantly in l‐configuration. On the other hand, a series of studies show that a variety of d‐amino acids also occur in mammals and amino acid homochirality is not complete. Mammals de novo synthesize most amino acids with l‐configuration, but serine and aspartate are converted from l‐ to d‐configuration by endogenous ...
Jumpei Sasabe, Sakiko Taniguchi, Kenichiro Adachi, Xuan Tran, Masataka Suzuki   +4 more
wiley   +1 more source

Programming Green Light‐Responsive Hydrogels: From Photo‐Weakening to Photo‐Unresponsiveness and Photo‐Strengthening

Chemistry – A European Journal, Volume 31, Issue 16, March 17, 2025.
The light response of CarHc protein‐based hydrogels can be alterted from photo‐weakening, to photo‐strengthening, or becoming light‐unresponsive depending on the added cofactors AdoCbl and Co2+. Under green light, CarHc tetramers disassembly weakens the hydrogel, while excess AdoCbl crosslinking poly‐histidine tags strengthens it.
Saskia Frank, Seraphine V. Wegner
wiley   +1 more source

The Role of Asparagine as a Gatekeeper Residue in the Selective Binding of Rare Earth Elements by Lanthanide‐Binding Peptides

Chemistry – A European Journal, EarlyView.
Lanthanide binding tags (LBTs) have been utilized as a green extractant to selectively separate rare earth elements (REEs). We reveal up from the molecular level how the N5 asparagine residue is indispensable in imparting selective complexation between lighter and heavier lanthanides by conformationally functioning as a gate.
Surabh S. KT, Baofu Qiao, Jason G. Marmorstein, Yiming Wang, Denize C. Favaro, Kathleen J. Stebe, E. James Petersson, Ravi Radhakrishnan, Cesar de la Fuente‐Nunez, Raymond S. Tu, Charles Maldarelli, Monica Olvera de la Cruz, Robert J. Messinger   +12 more
wiley   +1 more source

Unjamming Transition as a Paradigm for Biomechanical Control of Cancer Metastasis

Cytoskeleton, EarlyView.
ABSTRACT Tumor metastasis is a complex phenomenon that poses significant challenges to current cancer therapeutics. While the biochemical signaling involved in promoting motile phenotypes is well understood, the role of biomechanical interactions has recently begun to be incorporated into models of tumor cell migration.
Grace Cai, Nicole C. Rodgers, Allen P. Liu   +2 more
wiley   +1 more source

Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog. [PDF]

, 2019
People heterozygous for an activating mutation in protein kinase G1 (PRKG1, p.Arg177Gln) develop thoracic aortic aneurysms and dissections (TAAD) as young adults.
Boss, Gerry R, Casteel, Darren E, Dalton, Nancy D, Gu, Yusu, Kalyanaraman, Hema, Lee, Seunghoe, Makino, Ayako, Milewicz, Dianna M, Patel, Hemal H, Peterson, Kirk L, Pilz, Renate B, Schilling, Jan M, Schwaerzer, Gerburg K, Wahwah, Nisreen, Zhang, Qian, Zhuang, Shunhui   +15 more
core   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Connecting the dots: A narrative review of the relationship between heart failure and cognitive impairment

ESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.
Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi, Maria Giulia Bellicini, Marianna Adamo, Andrea Pilotto, Marco Metra, Alessandro Padovani, Riccardo Proietti   +6 more
wiley   +1 more source

Biomaterials‐Involved Construction of Extracellular Matrices for Tumor Blockade Therapy

Exploration, EarlyView.
Extracellular matrices (ECMs) play a crucial role in tumor growth and metastases by providing structural support and facilitating tumor cell proliferation. In this review, we explore the development of artificial ECMs engineered through biomineralization, fibrogenesis, and gelation. These bioinspired ECMs create a protective barrier around tumor cells,
Jinfeng Sun, Yang Liu, Jingshan Sun, Jianxun Ding, Xuesi Chen   +4 more
wiley   +1 more source