Results 61 to 70 of about 76,474 (248)

2.8 Unique patterns of elastin degradation in ascending aortic aneurysms in bicuspid aortic valve patients

Artery Research, 2020
Background: Bicuspid aortic valve patients (BAV) are associated with increased risk of ascending aortic aneurysms. However, is unclear whether matrix degradation varies in different ascending aneurysm aetiologies.
Ya Hua Chim, Hannah Davies, Omar Nawaytou, Mark Field, Jillian Madine, Riaz Akhtar   +5 more
doaj   +1 more source

Long‐Term Human Skin Platform for Modeling Chronic Inflammation, Environmental Stress, and Therapeutic Intervention

Advanced Science, EarlyView.
An advanced, long‐term human skin platform maintains native skin structure and key tissue functions for up to four weeks. The platform models chronic inflammation, aging‐related skin changes, and UVB damage, enabling drug and topical interventions—including anti‐inflammatory therapy, senolytic treatment, and sunscreen—to be evaluated in intact human ...
Purnendu Kumar Sharma, Evelien Schaafsma, Elysia Anderson, Jocelyn Chiari, Paige Thompson, Erin Galt, Sunghoon Lee, Jason Holsapple, Sai Hein, Bailey L. Coates, Jade Michaud, Sabrina Zuccaro, Lia Kent, Chris Hinojosa, Kyung‐Jin Jang   +14 more
wiley   +1 more source

OPTIMUM METHOD FOR COMMON CARP ELASTIN EXTRACTION AND THE ANTI-OXIDANT ACTIVITY OF ELASTIN ENZYMATIC HYDROLYSATE

The Iraqi Journal of Agricultural science
This study aimed to compare five protocols to optimize elastin purification, where purification protocols for elastin generally result in greatly damaged elastin fibres and this likely influences the biological response. The optimal protocol for elastin
A. M. Kadhim A. M. Kadhim, K. A. Shakir K. A. Shakir   +1 more
doaj   +1 more source

Induction of protein body formation in plant leaves by elastin-like polypeptide fusions

BMC Biology, 2009
Background Elastin-like polypeptides are synthetic biopolymers composed of a repeating pentapeptide 'VPGXG' sequence that are valuable for the simple non-chromatographic purification of recombinant proteins.
Joensuu Jussi J, Conley Andrew J, Menassa Rima, Brandle Jim E   +3 more
doaj   +1 more source

Bioinspired Modular Synthesis of Elastin-Mimic Polymers To Probe the Mechanism of Elastin Elasticity

, 2016
Bioinspired Modular Synthesis of Elastin-Mimic Polymers To Probe the Mechanism of Elastin ...
Zhibin Guan (1334145), Yulin Chen (284451)   +1 more
core   +1 more source

NCOA4 Accelerates Abdominal Aortic Aneurysm Formation by Regulating Macrophage Activation and Ferroptosis via STAT1–CH25H Axis

Advanced Science, EarlyView.
Under pathological stimulation, NCOA4 in macrophages interacts with STAT1 to promote CH25H transcription. The subsequent increase in 25‐HC production activates macrophages, triggers inflammatory responses and ferroptosis, and accelerates the progression of AAA.
Zhinan Wu, Yuxuan Qian, Wenyi Xu, Fei Liao, Xueliang Liu, Xiao Kuang, Guqing Luo, Xinjie He, Lixian Jiang, Song Ding   +9 more
wiley   +1 more source

Coacervate Droplet Sequestration of Heterogeneous Nanoplastics With Elastin‐Like Polypeptides

Angewandte Chemie, EarlyView.
Phase‐separated polypeptide droplets captured incidental nanoplastics as a reusable nanoplastic sink. The engineered droplets selectively partitioned nanoplastics and exhibited unique interactions depending on droplet type and nanoplastic identity, establishing biopolymer coacervates as a potential platform for nanoplastic characterization and removal.
Natalie R. Ling, Aashi Kotecha, Allie C. Obermeyer   +2 more
wiley   +2 more sources

Acquired Localized Cutis Laxa due to Increased Elastin Turnover

Case Reports in Dermatology, 2016
Cutis laxa is a rare disease characterized by abnormal skin wrinkling and laxity, due to decreased elastin synthesis or structural extracellular matrix defects.
Rie Harboe Nygaard, Scott Maynard, Peter Schjerling, Michael Kjaer, Klaus Qvortrup, Vilhelm A. Bohr, Lene J. Rasmussen, Gregor B.E. Jemec, Michael Heidenheim   +8 more
doaj   +1 more source

Is newly-secreted elastin cleaved to a smaller molecule before being incorporated into crosslinked elastin fibers?

, 1977
The biosynthesis of elastin was examined in matrix-free cells isolated by enzymatic digestion of aortas from 17 day old chick embryos. When the cells were incubated with (14C) proline and then were rapidly boiled in buffer containing high concentrations ...
BRESSAN, GIORGIO, Prockop DJ
core   +1 more source

Alkylating Agent–Induced FANCL Impairment Damages Pulmonary Arterial, Venous, and Microvascular Endothelial Cells and Predisposes to PAH/PVOD

Advanced Science, EarlyView.
This study establishes a novel cisplatin‐induced rat model of PAH/PVOD and identifies a conserved mechanistic axis—FANCL impairment, DNA damage accumulation, and endothelial dysfunction—triggered by cisplatin or mitomycin C across pulmonary arteries, veins, and microvessels.
Shiyun Liu, Yufei Sun, Xinlei Wu, Haixia Chen, Shaocong Mo, Zichong Li, Yiwei Gong, Xiaoqian Shan, Yuanqi Li, Yaru Guan, Junqi Zhu, Han Yan, Min Du, Feng Wei, Peixin Ou, Ziyi Wang, Chenting Zhang, Lei Xu, Wenju Lu, Jian Wang, Kai Yang   +20 more
wiley   +1 more source