Results 41 to 50 of about 69,247 (300)

Presenilin-1 in smooth muscle cells facilitates hypermuscularization in elastin aortopathy

iScience
Summary: Smooth muscle cell (SMC) accumulation is central to the pathogenesis of elastin-defective arterial diseases, including supravalvular aortic stenosis (SVAS).
Junichi Saito, Jui M. Dave, Freddy Duarte Lau, Daniel M. Greif   +3 more
doaj   +1 more source

Elastin‐Specific Autoimmunity in Smokers With Thoracic Aortic Aneurysm and Dissection is Independent of Chronic Obstructive Pulmonary Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Thoracic aortic aneurysm (TAA) and dissection (TAD) are characterized by progressive disorganization of the aortic wall matrix, including elastin, a highly immunogenic molecule.
Bon‐Hee Gu, Justin C. Choi, Ying H. Shen, Li‐Zhen Song, Michael E. Scheurer, Amber Luong, Antony Rodriguez, Prescott Woodruff, Laura Koth, David B. Corry, Farrah Kheradmand, Scott A. LeMaire   +11 more
doaj   +1 more source

Coaxially Electrospun Myocardial dECM‐ Based Nanofibrous Scaffolds Demonstrate Enhanced Cardiomyocyte Biocompatibility

Advanced Healthcare Materials, EarlyView.
Our coaxial electrospinning system is capable of incorporating decellularized myocardial extracellular matrix in a core‐sheath configuration, creating nanofibrous scaffolds. These scaffolds, in turn, support the maintenance of functional cardiomyocytes adhered to the surface of these bioactive scaffolds.
Dhanusha N. Rajapakse, Mahtab Khodadadi, Kiran M. Ali, Suh Hee Cook, Bryson T. Proctor, Tanya Upadhyay, Daxian Zha, Fatema Tuj Jahura, Marziyeh Boosaliki, Jessica M. Gluck   +9 more
wiley   +1 more source

PKCε Increases Extracellular Elastin and Fibulin-5/DANCE in Dermal Fibroblasts

Cellular Physiology and Biochemistry, 2018
Background/Aims: In the earlier study, the selective PKCε activator DCP-LA increased elastic fibres in the dermis of HR-1 hairless mice. As a process of elastic fibre formation, tropoelastin, an elastin monomer, is secreted into the extracellular space ...
Tomoyuki Nishizaki
doaj   +1 more source

Fabrication of Protein Films from Genetically Engineered Silk-Elastin-Like Proteins by Controlled Cross-Linking

, 2017
Protein films are an important class of materials for applications in biomedicine and biotechnology. The rational design of protein polymer sequence and selection of customized cross-linking offers unique opportunities to engineer desirable ...
Ming-Liang Zhou (1489033), Liang Chen (73736), Zhi-Gang Qian (1489027), Xiao-Xia Xia (1489030), David L. Kaplan (131325)   +4 more
core   +1 more source

Natural Biomaterials for Osteochondral Repair: From Source to Strategy

Advanced Healthcare Materials, EarlyView.
Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu, Hanyang Zhang, Wenbo Yang, Hao Chen, Jincheng Wang, Fei Chang   +5 more
wiley   +1 more source

Elastin degradation products in acute lung injury induced by gastric contents aspiration

Respiratory Research, 2018
Background Gastric contents aspiration is a high-risk condition for acute lung injury (ALI). Consequences range from subclinical pneumonitis to respiratory failure, depending on the volume of aspirate.
Pedro Ayala, Raúl Vivar, Rebeca Montalva, Pablo Olmos, Manuel Meneses, Gisella R. Borzone   +5 more
doaj   +1 more source

Heparan sulphate-elastin interactions in vivo and in vitro

, 2004
Investigation on the role of heparan sulfate-tropoelastin interactions in elastin ...
D. Quaglino, RONCHETTI, Ivonne, QUAGLINO, Daniela, D. Gheduzzi, Weiss A, GHEDUZZI, Dealba, Pepe A, Mithieux S, TAMBURRO, Antonio Mario, GUERRA, Deanna, PEPE, Antonietta, Tamburro A, Bochicchio B, D. Guerra, A. Weiss, I. Pasquali Ronchetti, BOCHICCHIO, Brigida, S. Mithieux   +17 more
core   +1 more source

Stable Protein‐Based G‐Quadruplex‐Derived Supramolecular Bioinks as Tunable ECM‐Mimetic Constructs Assembled by Combining Non‐Covalent and Covalent Strategies

Advanced Materials, EarlyView.
Harnessing the synergistic interplay of supramolecular self‐assembly, under macromolecular crowding conditions, and enzymatic‐mediated covalent crosslinking toward a stable protein‐based G‐quadruplex‐derived supramolecular bioink. This bioinspired strategy enables the biofabrication of complex and tunable ECM‐mimetic constructs, providing a platform ...
Vera Sousa, Rita Sobreiro‐Almeida, Bart W. L. van den Bersselaar, E. W. Meijer, Ghislaine Vantomme, João Borges, João F. Mano   +6 more
wiley   +1 more source

Applications of Elastin in Cosmetics: Prospects and Challenges

Cosmetics
Elastin is a crucial component of the extracellular matrix that plays a significant role in maintaining skin elasticity and firmness. Within the dermis, elastin works in collaboration with collagen to form supportive structures that contribute to the ...
Ting Lei, Lin Ye, Yunlin Pei, Huaiqing Sun, Chaowan Guo   +4 more
doaj   +1 more source