Results 51 to 60 of about 345,892 (194)

Elastin-Derived Peptide-Based Hydrogels as a Potential Drug Delivery System

Gels
A peptide-based hydrogel sequence was computationally predicted from the Ala-rich cross-linked domains of elastin. Three candidate peptides were subsequently synthesised and characterised as potential drug delivery vehicles.
Othman Al Musaimi, Keng Wooi Ng, Varshitha Gavva, Oscar M. Mercado-Valenzo, Hajira Banu Haroon, Daryl R. Williams   +5 more
doaj   +1 more source

Uncoupling of Elastin Complex Receptor during In Vitro Aging Is Related to Modifications in Its Intrinsic Sialidase Activity and the Subsequent Lactosylceramide Production. [PDF]

PLoS ONE, 2015
Degradation of elastin leads to the production of elastin-derived peptides (EDP), which exhibit several biological effects, such as cell proliferation or protease secretion.
Amandine Scandolera, Fanja Rabenoelina, Carine Chaintreuil, Anthony Rusciani, Pascal Maurice, Sébastien Blaise, Béatrice Romier-Crouzet, Hassan El Btaouri, Laurent Martiny, Laurent Debelle, Laurent Duca   +10 more
doaj   +1 more source

Silk Fibroin for Cardiovascular Medical Devices: Review of Material Properties, Applications, and Clinical Potential

Advanced NanoBiomed Research, EarlyView.
Silk fibroin is an attractive natural biomaterial that can be engineered into diverse cardiovascular constructs, including vascular grafts, cardiac patches, heart valves, and stent coatings. Its tunable biological and mechanical properties have driven substantial preclinical progress; however, widespread clinical translation in cardiovascular ...
Mahsa Haghighattalab, Matt Govendir, Kristina Andelovic, Zachary Och, Fatemeh Karimi, Munira Xaymardan, Tomasz Jungst, Jelena Rnjak‐Kovacina, Nona Farbehi   +8 more
wiley   +1 more source

The elastin peptide VGVAPG increases CD4+ T-cell IL-4 production in patients with chronic obstructive pulmonary disease

Respiratory Research, 2021
Background In chronic obstructive pulmonary disease (COPD), lung-infiltrating inflammatory cells secrete proteases and participate in elastin breakdown and genesis of elastin-derived peptides (EP).
Flora Lemaire, Sandra Audonnet, Jeanne-Marie Perotin, Pierre Gaudry, Sandra Dury, Julien Ancel, François Lebargy, Frank Antonicelli, Gaëtan Deslée, Richard Le Naour   +9 more
doaj   +1 more source

Protein-Engineered Polymers Functionalized with Antimicrobial Peptides for the Development of Active Surfaces

Applied Sciences, 2021
Antibacterial resistance is a major worldwide threat due to the increasing number of infections caused by antibiotic-resistant bacteria with medical devices being a major source of these infections.
Ana Margarida Pereira, Diana Gomes, André da Costa, Simoni Campos Dias, Margarida Casal, Raul Machado   +5 more
doaj   +1 more source

Conformational Dependence of Collagenase (Matrix Metalloproteinase-1) Up-regulation by Elastin Peptides in Cultured Fibroblasts

, 2001
International audienceWe have established that treatment of cultured human skin fibroblasts with tropoelastin or with heterogenic peptides, obtained after organo-alkaline or leukocyte elastase hydrolysis of insoluble elastin, induces a high expression of
Tamburro, Antonio, Alix, Alain, Hornebeck, William, Delacoux, Frédéric, Fuchs, Patrick, Huet, Eric, Haye, Bernard, Debelle, Laurent, Emonard, Hervé, Brassart, Bertrand, Wallach, Jean   +10 more
core   +1 more source

Elastin hydrogels

, 2023
This bachelor thesis is focused on elastin hydrogels for medical application. The aim of the experimental part was using elastin as an additional substance in polysaccharide gel matrices.
Burianová, Veronika
core   +1 more source

Elastin molecular aging promotes MDA‐MB‐231 breast cancer cell invasiveness

FEBS Open Bio, 2018
Elastin is a long‐lived extracellular matrix protein responsible for the structural integrity and function of tissues. Breast cancer elastosis is a complex phenomenon resulting in both the deposition of elastotic masses and the local production of ...
Stéphanie Salesse, Ludivine Odoul, Lise Chazée, Christian Garbar, Laurent Duca, Laurent Martiny, Rachid Mahmoudi, Laurent Debelle   +7 more
doaj   +1 more source

Elastin in the Liver

Frontiers in Physiology, 2016
A characteristic feature of liver cirrhosis is the accumulation of large amounts of connective tissue with the prevailing content of type I collagen. Elastin is a minor connective tissue component in normal liver but it is actively synthesized by hepatic
Jiri Kanta
doaj   +1 more source

Host Cell Protein Challenges in Antibody Processing: Insights Into Persistence and Mitigation Strategies

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Persistence of HCPs remains a major purification challenge in biopharmaceutical manufacturing with direct consequences for product quality, patient safety, and regulatory compliance. Over the last two decades, deeper insights into the mechanisms driving HCP persistence have clarified why certain proteins evade removal during purification ...
Younghoon Oh, Andrew Cooke, Harshal Soni, Susan Liu, Mamadou Bah, Brianna Bellis, Laura Smith, Michael Capaldi, Nicholas Levy, Erik Wilhelm, Kristopher Barnthouse   +10 more
wiley   +1 more source