Results 1 to 10 of about 11,334 (149)
Association between serum elastin-derived peptides and abdominal aortic calcification in peritoneal dialysis patients: a cross-sectional study [PDF]
Renal Failure, 2021 Background Peritoneal dialysis (PD) patients experience accelerated arterial aging, which is characterized by elastin degradation. Elastin-derived peptides (EDPs) are direct products of elastin fragmentation.
Shizhu Zhao +6 more
doaj +3 more sources
Adipocyte, 2020 Elastin is a highly elastic protein present in connective tissue. As a result of protease activity, elastin hydrolysis occurs, and during this process, elastin-derived peptides (EDPs) are released.
Konrad A. Szychowski +3 more
doaj +2 more sources
Targeting Elastin‐Derived Peptides Reverses Alveolar Epithelial Dysfunction in Chronic Obstructive Pulmonary Disease [PDF]
MedCommChronic obstructive pulmonary disease (COPD) is characterized by progressive alveolar destruction and defective regeneration, yet the matrix‐derived factors contributing to this process remain poorly defined.
Huijuan Zhu +14 more
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Matrix metalloproteinase-12 in arterial diseases: context-dependent mechanisms of vascular remodeling and therapeutic implications [PDF]
Frontiers in Cardiovascular MedicineMaladaptive vascular remodeling is a shared feature of diverse arterial disorders and arises from a self-reinforcing interplay between inflammation and extracellular matrix (ECM) turnover.
Yifan Luo +3 more
doaj +2 more sources
Elastin-Derived Peptides in the Central Nervous System: Friend or Foe. [PDF]
Cell Mol Neurobiol, 2022 Szychowski KA, Skóra B, Wójtowicz AK.
europepmc +2 more sources
Engineered elastin-like polypeptides: An efficient platform for enhanced cancer treatment
Frontiers in Pharmacology, 2023 Drug delivery systems (DDSs) have recently gained widespread attention for improving drug loading and delivery efficiency in treating many cancers. Elastin-like polypeptides (ELPs) are synthetic peptides derived from a precursor of elastin (tropoelastin),
Aiguo Jiang +4 more
doaj +1 more source
Materials Today Bio, 2022 Harnessing the inflammation and angiogenesis is extremely important in wound healing. In this study, we developed bioactive elastin-based hydrogels which can recruit and modulate the innate immune cells and accelerate angiogenesis in the wound site and ...
Duo-Mei Tian +19 more
doaj +1 more source
Recent Advances in Elastin-Based Biomaterial
Journal of Pharmacy & Pharmaceutical Sciences, 2020 Elastin is one of the main components of the extracellular matrix; it provides resistance and elasticity to a variety of tissues and organs of the human body, besides participating in cellular signaling.
María Luisa Del Prado Audelo +7 more
doaj +1 more source
Cells, 2023 Abnormal turnover of the extracellular matrix (ECM) protein elastin has been linked to AMD pathology. Elastin is a critical component of Bruch’s membrane (BrM), an ECM layer that separates the retinal pigment epithelium (RPE) from the underlying ...
Soumya Navneet +3 more
doaj +1 more source
The Elastin Receptor Complex: An Emerging Therapeutic Target Against Age-Related Vascular Diseases
Frontiers in Endocrinology, 2022 The incidence of cardiovascular diseases is increasing worldwide with the growing aging of the population. Biological aging has major influence on the vascular tree and is associated with critical changes in the morphology and function of the arterial ...
Dignê Tembely +12 more
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