Application of Elastin-like Polypeptide in Tumor Therapy. [PDF]
Cancers (Basel), 2022 Elastin-like polypeptides (ELPs) are stimulus-responsive artificially designed proteins synthesized from the core amino acid sequence of human tropoelastin. ELPs have good biocompatibility and biodegradability and do not systemically induce adverse immune responses, making them a suitable module for drug delivery.
Shi X +8 more
europepmc +4 more sources
Elastin-like Polypeptide Hydrogels for Tunable, Sustained Local Chemotherapy in Malignant Glioma [PDF]
Pharmaceutics, 2022 Glioblastoma (GBM) is a primary brain tumor that carries a dismal prognosis, which is primarily attributed to tumor recurrence after surgery and resistance to chemotherapy. Since the tumor recurrence appears near the site of surgical resection, a concept
Sonja Dragojevic +4 more
doaj +4 more sources
Elastin-like polypeptide modified silk fibroin porous scaffold promotes osteochondral repair [PDF]
Bioactive Materials, 2021 Silk fibroin (SF) is considered biocompatible and biodegradable for osteochondral repair. However, it lacks a bioactive domain for cell adhesion, proliferation and differentiation, limiting its therapeutic efficacy.
Zhuoyue Chen +5 more
doaj +4 more sources
pH-Responsive Elastin-Like Polypeptide Designer Condensates. [PDF]
ACS Appl Mater Interfaces, 2023 Biomolecular condensates are macromolecular complexes formed by liquid-liquid phase separation. They regulate key biological functions by reversibly compartmentalizing molecules in cells, in a stimulus-dependent manner. Designing stimuli-responsive synthetic condensates is crucial for engineering compartmentalized synthetic cells that are able to mimic
de Haas RJ +3 more
europepmc +4 more sources
Construction of a Collagen-like Protein Based on Elastin-like Polypeptide Fusion and Evaluation of Its Performance in Promoting Wound Healing [PDF]
Molecules, 2023 In the healing of wounds, human-like collagen (hCol) is essential. However, collagen-based composite dressings have poor stability in vivo, which severely limits their current therapeutic potential.
Yingli Chen +9 more
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Exploring stimuli-responsive elastin-like polypeptide for biomedicine and beyond: potential application as programmable soft actuators [PDF]
Frontiers in Bioengineering and Biotechnology, 2023 With the emergence of soft robotics, there is a growing need to develop actuator systems that are lightweight, mechanically compliant, stimuli-responsive, and readily programmable for precise and intelligent operation.
Yeongjin Noh, Eunjoo Son, Chaenyung Cha
doaj +2 more sources
Rational design and preclinical evaluation of elastin-like polypeptide micelle nanoparticles for drug delivery [PDF]
Frontiers in Bioengineering and BiotechnologyElastin-like polypeptide (ELP) micelle nanoparticles have emerged as versatile and tunable platforms for drug delivery across diseases. These bio-inspired and thermo-responsive polymers typically produced recombinantly in E.coli or yeast offer great ...
Abdulhakim Tofik +3 more
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Elastin-like polypeptide coacervates as reversibly triggerable compartments for synthetic cells [PDF]
Communications ChemistryCompartmentalization is a vital aspect of living cells to orchestrate intracellular processes. In a similar vein, constructing dynamic and responsive sub-compartments is key to synthetic cell engineering.
Chang Chen +6 more
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Two-step purification of elastin-like polypeptide-fusion superoxide dismutase via hydrophobicity and thermoresponsiveness [PDF]
Frontiers in Bioengineering and BiotechnologyIntroductionSuperoxide dismutase (SOD) catalyzes the dismutation of superoxide radicals to oxygen and hydrogen peroxide, serving as a key antioxidant enzyme with important therapeutic and industrial applications.
Weiwei Wang +12 more
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Application of Bio-Active Elastin-like Polypeptide on Regulation of Human Mesenchymal Stem Cell Behavior [PDF]
Biomedicines, 2022 Regenerative medicine using stem cells offers promising strategies for treating a variety of degenerative diseases. Regulation of stem cell behavior and rejuvenate senescence are required for stem cells to be clinically effective.
Vijaya Sarangthem +7 more
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