Targeted paclitaxel delivery in ovarian cancer via AP1-functionalized elastin-like polypeptide nanocarriers: development and characterization [PDF]
BMC CancerPaclitaxel has been a cornerstone of ovarian cancer chemotherapy for over two decades. However, its clinical application is constrained by poor solubility and non-specific delivery, resulting in systemic toxicity and inconsistent therapeutic outcomes ...
Ridhima Goel +6 more
doaj +2 more sources
FT-IR Spectroscopic Analysis of the Secondary Structures Present during the Desiccation Induced Aggregation of Elastin-Like Polypeptide on Silica. [PDF]
ACS Omega, 2020 Previously, we found that elastin-like polypeptide (ELP), when dried above the lower critical solution temperature on top of a hydrophilic fused silica disk, exhibited a dynamic coalescence behavior. The ELP initially wet the silica, but over the next 12
Cobb JS +3 more
europepmc +2 more sources
Multifunctional elastin-like polypeptide renders β-glucosidase enzyme phase transition and high stability [PDF]
Biotechnology for Biofuels, 2019 Background In the enzymatic conversion of biomass, it becomes an important issue to efficiently and cost-effectively degrade cellulose into fermentable glucose. β-Glucosidase (Bgluc), an essential member of cellulases, plays a critical role in cellulosic
Yang Zhou +10 more
doaj +2 more sources
An Elastin-like Polypeptide-fusion peptide targeting capsid-tegument interface as an antiviral against cytomegalovirus infection [PDF]
Scientific ReportsThe tegument protein pp150 of Human Cytomegalovirus (HCMV) is known to be essential for the final stages of virus maturation and mediates its functions by interacting with capsid proteins.
Komal Beeton +6 more
doaj +2 more sources
Molecules, 2009 A well characterized, peptide derivative of bovine lactoferrin, L12, has been shown to possess anticancer properties in multiple cell lines. However, adverse side effects in normal tissues and poor plasma kinetics that hinder the clinical effectiveness ...
Emily Thomas +2 more
doaj +3 more sources
Novel Protein Therapeutics Created Using the Elastin-Like Polypeptide Platform
Physiology, 2021 Gene L Bidwell Iii
exaly +2 more sources
Construction and application of elastin like polypeptide containing IL-4 receptor targeting peptide. [PDF]
PLoS ONE, 2013 Various human solid tumors highly express IL-4 receptors which amplify the expression of some of anti-apoptotic proteins, preventing drug-induced cancer cell death. Thus, IL-4 receptor targeted drug delivery can possibly increase the therapeutic efficacy
Vijaya Sarangthem +8 more
doaj +1 more source
Elastin-like polypeptide-based micelles as a promising platform in nanomedicine.
Journal of Controlled Release, 2022 New and improved nanomaterials are constantly being developed for biomedical purposes. Nanomaterials based on elastin-like polypeptides (ELPs) have increasingly shown potential over the past two decades.
Jolinde van Strien +4 more
semanticscholar +1 more source
Journal of Nanobiotechnology, 2023 Elastin-like polypeptides (ELPs) are thermally responsive biopolymers derived from natural elastin. These peptides have a low critical solution temperature phase behavior and can be used to prepare stimuli-responsive biomaterials.
Yingshu Guo +4 more
doaj +1 more source
Advanced Science, 2021 Design of reversible organelle‐like microcompartments formed by liquid–liquid phase separation in cell‐mimicking entities has significantly advanced the bottom‐up construction of artificial eukaryotic cells.
Hang Zhao +5 more
doaj +1 more source