Elastin-like Polypeptide Hydrogels for Tunable, Sustained Local Chemotherapy in Malignant Glioma [PDF]
Pharmaceutics, 2022 Glioblastoma (GBM) is a primary brain tumor that carries a dismal prognosis, which is primarily attributed to tumor recurrence after surgery and resistance to chemotherapy. Since the tumor recurrence appears near the site of surgical resection, a concept
Sonja Dragojevic +4 more
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Elastin-like polypeptide modified silk fibroin porous scaffold promotes osteochondral repair [PDF]
Bioactive Materials, 2021 Silk fibroin (SF) is considered biocompatible and biodegradable for osteochondral repair. However, it lacks a bioactive domain for cell adhesion, proliferation and differentiation, limiting its therapeutic efficacy.
Zhuoyue Chen +5 more
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Construction of a Collagen-like Protein Based on Elastin-like Polypeptide Fusion and Evaluation of Its Performance in Promoting Wound Healing [PDF]
Molecules, 2023 In the healing of wounds, human-like collagen (hCol) is essential. However, collagen-based composite dressings have poor stability in vivo, which severely limits their current therapeutic potential.
Yingli Chen +9 more
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Exploring stimuli-responsive elastin-like polypeptide for biomedicine and beyond: potential application as programmable soft actuators [PDF]
Frontiers in Bioengineering and Biotechnology, 2023 With the emergence of soft robotics, there is a growing need to develop actuator systems that are lightweight, mechanically compliant, stimuli-responsive, and readily programmable for precise and intelligent operation.
Yeongjin Noh, Eunjoo Son, Chaenyung Cha
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Rational design and preclinical evaluation of elastin-like polypeptide micelle nanoparticles for drug delivery [PDF]
Frontiers in Bioengineering and BiotechnologyElastin-like polypeptide (ELP) micelle nanoparticles have emerged as versatile and tunable platforms for drug delivery across diseases. These bio-inspired and thermo-responsive polymers typically produced recombinantly in E.coli or yeast offer great ...
Abdulhakim Tofik +3 more
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Elastin-like polypeptide coacervates as reversibly triggerable compartments for synthetic cells [PDF]
Communications ChemistryCompartmentalization is a vital aspect of living cells to orchestrate intracellular processes. In a similar vein, constructing dynamic and responsive sub-compartments is key to synthetic cell engineering.
Chang Chen +6 more
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Multifunctional elastin-like polypeptide nanocarriers for efficient miRNA delivery in cancer therapy [PDF]
Journal of NanobiotechnologyBackground The exogenous delivery of miRNA to mimic and restore miRNA-34a activity in various cancer models holds significant promise in cancer treatment.
Jisan Hong +4 more
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Two-step purification of elastin-like polypeptide-fusion superoxide dismutase via hydrophobicity and thermoresponsiveness [PDF]
Frontiers in Bioengineering and BiotechnologyIntroductionSuperoxide dismutase (SOD) catalyzes the dismutation of superoxide radicals to oxygen and hydrogen peroxide, serving as a key antioxidant enzyme with important therapeutic and industrial applications.
Weiwei Wang +12 more
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Application of Bio-Active Elastin-like Polypeptide on Regulation of Human Mesenchymal Stem Cell Behavior [PDF]
Biomedicines, 2022 Regenerative medicine using stem cells offers promising strategies for treating a variety of degenerative diseases. Regulation of stem cell behavior and rejuvenate senescence are required for stem cells to be clinically effective.
Vijaya Sarangthem +7 more
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Application of bioengineered elastin-like polypeptide-based system for targeted gene delivery in tumor cells [PDF]
Biomaterials and Biosystems, 2022 Successful gene delivery depends on the entry of negatively charged DNAs and oligonucleotides across the various barriers of the tumor cells and localization into the nucleus for its transcription and protein translation. Here, we have reported a thermal
Aena Yi +4 more
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