Construction of Thermo-Responsive Elastin-Like Polypeptides (ELPs)-Aggregation-Induced-Emission (AIE) Conjugates for Temperature Sensing [PDF]
Molecules, 2018 In this work, an aggregation-induced emission (AIE) molecule (tetraphenylethene derivative, TPE-COOH) was conjugated to elastin-like polypeptides (ELPs40) via an amide bond to form ELPs40-TPE.
Zhe Chen +4 more
doaj +4 more sources
Engineered elastin-like polypeptides: An efficient platform for enhanced cancer treatment [PDF]
Frontiers in Pharmacology, 2023 Drug delivery systems (DDSs) have recently gained widespread attention for improving drug loading and delivery efficiency in treating many cancers. Elastin-like polypeptides (ELPs) are synthetic peptides derived from a precursor of elastin (tropoelastin),
Aiguo Jiang +4 more
doaj +2 more sources
Engineering elastic sealants based on gelatin and elastin‐like polypeptides for endovascular anastomosis [PDF]
Bioengineering & Translational Medicine, 2021 Cerebrovascular ischemia from intracranial atherosclerosis remains difficult to treat. Although current revascularization procedures, including intraluminal stents and extracranial to intracranial bypass, have shown some benefit, they suffer from ...
Gokberk Unal +8 more
doaj +2 more sources
The construction of elastin-like polypeptides and their applications in drug delivery system and tissue repair [PDF]
Journal of Nanobiotechnology, 2023 Elastin-like polypeptides (ELPs) are thermally responsive biopolymers derived from natural elastin. These peptides have a low critical solution temperature phase behavior and can be used to prepare stimuli-responsive biomaterials.
Yingshu Guo +4 more
doaj +2 more sources
Enhancing the Physical Properties of Calcium Silicate Cement Modified with Elastin-like Polypeptides and Bioactive Glass [PDF]
Journal of Functional BiomaterialsConventional calcium silicate cement (CSC) formulations often exhibit insufficient mechanical strength and low initial stability. This study aimed to develop an organic–inorganic hybrid biomaterial by incorporating an elastin-like polypeptide (ELP ...
Jiyoung Kwon, Hyun-Jung Kim
doaj +2 more sources
A Rationalization of the Effect That TMAO, Glycine, and Betaine Exert on the Collapse of Elastin-like Polypeptides [PDF]
Life, 2022 Elastin-like polypeptides (ELPs) are soluble in water at low temperature, but, on increasing the temperature, they undergo a reversible and cooperative, coil-to-globule collapse transition.
Andrea Pica, Giuseppe Graziano
doaj +2 more sources
A Novel Protein Purification Approach Using Elastin-Like Polypeptides (ELP) With His-Tag Assistance [PDF]
Bio-ProtocolProtein purification is essential for drug development, antibody production, and structural biology. We propose a cost-effective chromatography method using elastin-like polypeptide (ELP) as an aggregating core.
Young Chae, Han Shin
doaj +2 more sources
Thermally-Responsive Loading and Release of Elastin-Like Polypeptides from Contact Lenses [PDF]
Pharmaceutics, 2019 Contact lenses are widely prescribed for vision correction, and as such they are an attractive platform for drug delivery to the anterior segment of the eye.
Wan Wang +4 more
doaj +2 more sources
Evaluation of Elastin-Like Polypeptides for Tumor Targeted Delivery of Doxorubicin to Glioblastoma [PDF]
Molecules, 2019 To increase treatment efficiency for glioblastoma, we have developed a system to selectively deliver chemotherapeutic doxorubicin (Dox) to Glioblastoma (GBM) tumors.
Sonja Dragojevic +2 more
doaj +2 more sources
Biomimetic Elastin-Like Polypeptides as Materials for the Activation of Mechanophoric Catalysts
Organic Materials, 2020 Elastin-like polypeptides (ELPs) are well known for their elastic and thermoresponsive behaviors. Their elasticity originates from the formation of a β-spiral which is the consequence of stacking type-II β-turns, formed from individual VPGVG pentapeptide
Sebastian Funtan +3 more
doaj +3 more sources