Applications of elastin-like polypeptides in drug delivery [PDF]
Journal of Controlled Release, 2014 Elastin-like polypeptides (ELPs) are biopolymers inspired by human elastin. Their lower critical solution temperature phase transition behavior and biocompatibility make them useful materials for stimulus-responsive applications in biological environments.
Ashutosh Chilkoti, Sarah Macewan
exaly +5 more sources
A Rationalization of the Effect That TMAO, Glycine, and Betaine Exert on the Collapse of Elastin-like Polypeptides [PDF]
Life, 2022 Elastin-like polypeptides (ELPs) are soluble in water at low temperature, but, on increasing the temperature, they undergo a reversible and cooperative, coil-to-globule collapse transition.
Andrea Pica, Giuseppe Graziano
doaj +4 more sources
Construction of Thermo-Responsive Elastin-Like Polypeptides (ELPs)-Aggregation-Induced-Emission (AIE) Conjugates for Temperature Sensing [PDF]
Molecules, 2018 In this work, an aggregation-induced emission (AIE) molecule (tetraphenylethene derivative, TPE-COOH) was conjugated to elastin-like polypeptides (ELPs40) via an amide bond to form ELPs40-TPE.
Zhe Chen +4 more
doaj +4 more sources
Engineered elastin-like polypeptides: An efficient platform for enhanced cancer treatment [PDF]
Frontiers in Pharmacology, 2023 Drug delivery systems (DDSs) have recently gained widespread attention for improving drug loading and delivery efficiency in treating many cancers. Elastin-like polypeptides (ELPs) are synthetic peptides derived from a precursor of elastin (tropoelastin),
Aiguo Jiang +4 more
doaj +2 more sources
Engineering elastic sealants based on gelatin and elastin‐like polypeptides for endovascular anastomosis [PDF]
Bioengineering & Translational Medicine, 2021 Cerebrovascular ischemia from intracranial atherosclerosis remains difficult to treat. Although current revascularization procedures, including intraluminal stents and extracranial to intracranial bypass, have shown some benefit, they suffer from ...
Gokberk Unal +8 more
doaj +2 more sources
Elastin-Like Polypeptides for Biomedical Applications [PDF]
Annual Review of Biomedical Engineering, 2020 Elastin-like polypeptides (ELPs) are stimulus-responsive biopolymers derived from human elastin. Their unique properties—including lower critical solution temperature phase behavior and minimal immunogenicity—make them attractive materials for a variety of biomedical applications.
Ashutosh Chilkoti
exaly +3 more sources
The construction of elastin-like polypeptides and their applications in drug delivery system and tissue repair [PDF]
Journal of Nanobiotechnology, 2023 Elastin-like polypeptides (ELPs) are thermally responsive biopolymers derived from natural elastin. These peptides have a low critical solution temperature phase behavior and can be used to prepare stimuli-responsive biomaterials.
Yingshu Guo +4 more
doaj +2 more sources
Emerging Role of Elastin-Like Polypeptides in Regenerative Medicine. [PDF]
Adv Wound Care (New Rochelle), 2021 Significance: Wound dressing based on naturally derived polymer provides a useful platform for treatment of skin injuries. Owing to the high mechanical strength and tunable structural and physicochemical properties of human elastin-like polypeptides (ELPs), they may be used as excellent materials for fabricating
Sarangthem V, Singh TD, Dinda AK.
europepmc +3 more sources
Enhancing the Physical Properties of Calcium Silicate Cement Modified with Elastin-like Polypeptides and Bioactive Glass [PDF]
Journal of Functional BiomaterialsConventional calcium silicate cement (CSC) formulations often exhibit insufficient mechanical strength and low initial stability. This study aimed to develop an organic–inorganic hybrid biomaterial by incorporating an elastin-like polypeptide (ELP ...
Jiyoung Kwon, Hyun-Jung Kim
doaj +2 more sources
Elastin-like Polypeptides in Development of Nanomaterials for Application in the Medical Field
Frontiers in Nanotechnology, 2022 Elastin-like polypeptides (ELPs) are biopolymers formed by amino acid sequences derived from tropoelastin. These biomolecules can be soluble below critical temperatures, forming aggregates at higher temperatures, which makes them an interesting source ...
Letícia Ferreira Lima +19 more
doaj +3 more sources