Results 31 to 40 of about 3,029 (158)
Application of Elastin-like Polypeptide in Tumor Therapy
Cancers, 2022 Elastin-like polypeptides (ELPs) are stimulus-responsive artificially designed proteins synthesized from the core amino acid sequence of human tropoelastin. ELPs have good biocompatibility and biodegradability and do not systemically induce adverse immune responses, making them a suitable module for drug delivery.
Xianggang Shi +8 more
openaire +2 more sources
Unique Phase Transition of Exogenous Fusion Elastin-like Polypeptides in the Solution Containing Polyethylene Glycol [PDF]
International Journal of Molecular Sciences, 2019 , Xialan Li, Zhang Guangya
exaly +2 more sources
Elastin-like polypeptides: Therapeutic applications for an emerging class of nanomedicines [PDF]
Journal of Controlled Release, 2016 Sarah Hamm-Alvarez +2 more
exaly +2 more sources
Frontiers in Bioengineering and Biotechnology, 2018 Stimuli-responsive hydrogel matrices are inspiring manifold applications in controlled delivery of bioactive compounds. Elastin-derived polypeptides form hydrogel matrices that may release bioactive moieties as a function of local increase of active ...
Antonella Bandiera +4 more
doaj +1 more source
Corneal Penetrating Elastin-Like Polypeptide Carriers [PDF]
Journal of Ocular Pharmacology and Therapeutics, 2016 Elastin-like polypeptide (ELP) is a bioengineered protein widely applied as a drug carrier due to its biocompatibility and amenability to modification with cell-penetrating peptides (CPPs) and therapeutic agents. The purpose of this study was to determine whether topically applied ELP or CPP-fused ELPs penetrate the corneal barrier.In vitro binding and
Eric M, George +4 more
openaire +2 more sources
BioTechniques, 2016 The protocol described here is designed as an extension of existing techniques for creating elastin-like polypeptides. It allows for the expression and purification of elastin-like polypeptide (ELP) constructs that are poorly expressed or have very low ...
Markian S. Bahniuk +2 more
doaj +1 more source
Elastin-Like Polypeptide Based Hydroxyapatite Bionanocomposites [PDF]
Biomacromolecules, 2011 In nature, organic matrix macromolecules play a critical role in enhancing the mechanical properties of biomineralized composites such as bone and teeth. Designing artificial matrix analogues is promising but challenging because relatively little is known about how natural matrix components function.
Eddie, Wang +2 more
openaire +2 more sources
Fusions of Elastin-Like Polypeptides to Pharmaceutical Proteins [PDF]
, 2012 Elastin-like polypeptides (ELPs) are a class of stimulus-responsive biopolymers whose physicochemical properties and biocompatibility are particularly suitable for in vivo applications, such as drug delivery and tissue engineering. The lower critical solution temperature (LCST) behavior of ELPs allows them to be utilized as soluble macromolecules below
Wafa, Hassouneh +2 more
openaire +2 more sources
Biophysical Characterization of an Elastin-Like-Polypeptide [PDF]
Biophysical Journal, 2011 Perhaps the largest impediment in cancer therapies has been the inability to effectively target systemically delivered therapeutics to cancerous cells. A recent and novel approach to this problem has been to chemically conjugate the therapeutic to an Elastin-Like-Polypeptide (ELP).
Lyons, Daniel +4 more
openaire +1 more source
Frontiers in Bioengineering and Biotechnology, 2022 The incorporation of non-canonical amino acids (ncAAs) using engineered aminoacyl-tRNA synthetases (aaRSs) has emerged as a powerful methodology to expand the chemical repertoire of proteins.
Osher Gueta +8 more
doaj +1 more source