Applications of elastin-like polypeptides in drug delivery. [PDF]
J Control Release, 2014 Elastin-like polypeptides (ELPs) are biopolymers inspired by human elastin. Their lower critical solution temperature phase transition behavior and biocompatibility make them useful materials for stimulus-responsive applications in biological environments.
MacEwan SR, Chilkoti A.
europepmc +5 more sources
Intracellular Delivery of Rapamycin From FKBP Elastin-Like Polypeptides Is Consistent With Macropinocytosis [PDF]
Frontiers in Pharmacology, 2018 Rapamycin (Rapa) is a highly potent drug; however, its clinical potential is limited by poor solubility, bioavailability, and cytotoxicity. To improve Rapa delivery, our team has fused the cognate protein receptor for Rapa, FKBP12, to high molecular ...
Santosh Peddi +4 more
doaj +2 more sources
Isolation of nucleic acids using liquid–liquid phase separation of pH-sensitive elastin-like polypeptides [PDF]
Scientific ReportsExtraction of nucleic acids (NAs) is critical for many methods in molecular biology and bioanalytical chemistry. NA extraction has been extensively studied and optimized for a wide range of applications and its importance to society has significantly ...
Telmo Díez Pérez +6 more
doaj +2 more sources
Self-assembly/disassembly hysteresis of nanoparticles composed of marginally soluble, short elastin-like polypeptides [PDF]
Journal of Nanobiotechnology, 2018 Background Elastin-like polypeptides (ELPs) are a fascinating biomaterial that has undergone copious development for a variety of therapeutic applications including as a nanoscale drug delivery vehicle.
Markian S. Bahniuk +3 more
doaj +2 more sources
Novel hemostatic biomolecules based on elastin-like polypeptides and the self-assembling peptide RADA-16 [PDF]
BMC Biotechnology, 2018 Background Safe and effective hemostatic materials are important for reducing mortality resulting from excessive hemorrhage. In this work, new biomaterials with hemostatic effects were created by fusing the gene coding for RADA-16, a self-assembling ...
Shasha Yang +8 more
doaj +2 more sources
Intracellular Delivery of a p21-Derived Cell Cycle Inhibitory Peptide Using Elastin-like Polypeptides Suppresses Glioblastoma Cell Proliferation [PDF]
MoleculesGlioblastoma, with a 5-year survival rate of just under 7.0%, is the most common form of brain cancer in adults. In this study, we evaluated the antiproliferative activity of the biopolymer p21-ELP1-Bac, a p21-derived peptide delivered via an elastin ...
Tiffany Quinn +2 more
doaj +2 more sources
Emerging Role of Elastin-Like Polypeptides in Regenerative Medicine. [PDF]
Adv Wound Care (New Rochelle), 2021 Significance: Wound dressing based on naturally derived polymer provides a useful platform for treatment of skin injuries. Owing to the high mechanical strength and tunable structural and physicochemical properties of human elastin-like polypeptides (ELPs), they may be used as excellent materials for fabricating
Sarangthem V, Singh TD, Dinda AK.
europepmc +3 more sources
Refining the Design of Diblock Elastin-Like Polypeptides for Self-Assembly into Nanoparticles. [PDF]
Polymers (Basel), 2021 Dai M +8 more
europepmc +2 more sources
One-Pot Synthesis of Multiple Stimuli-Responsive Magnetic Nanomaterials Based on the Biomineralization of Elastin-like Polypeptides [PDF]
ACS Omega, 2021 Yanhong Zhou +4 more
doaj +2 more sources
Engineering the Architecture of Elastin-Like Polypeptides: From Unimers to Hierarchical Self-Assembly. [PDF]
Adv Ther (Weinh), 2020 Saha S +4 more
europepmc +2 more sources