Results 21 to 30 of about 3,027 (160)

Trends in the Development of Tailored Elastin-Like Recombinamer–Based Porous Biomaterials for Soft and Hard Tissue Applications

Frontiers in Materials, 2021
Porous biomaterials are of significant interest in a variety of biomedical applications as they enable the diffusion of nutrients and gases as well as the removal of metabolic waste from implants.
Lubinda Mbundi, Lubinda Mbundi, Miguel González-Pérez, Fernando González-Pérez, Diana Juanes-Gusano, José Carlos Rodríguez-Cabello   +5 more
doaj   +1 more source

Pathway‐Dependent Co‐Assembly of Elastin‐Like Polypeptides [PDF]

Small, 2021
AbstractIn natural systems, temperature‐induced assembly of biomolecules can lead to the formation of distinct assembly states, created out of the same set of starting compounds, based on the heating trajectory followed. Until now it has been difficult to achieve similar behavior in synthetic polymer mixtures.
Jan Pille, Antonio Aloi, Duc H. T. Le, Ilia Vialshin, Nathalie van de Laar, Kirsten Kevenaar, Maarten Merkx, Ilja K. Voets, Jan C. M. van Hest   +8 more
openaire   +2 more sources

Biodegradation of elastin‐like polypeptide nanoparticles [PDF]

Protein Science, 2012
AbstractProtein polymers are repetitive polypeptides produced by ribosomal biosynthetic pathways; furthermore, they offer emerging opportunities in drug and biopharmaceutical delivery. As for any polymer, biodegradation is one of the most important determinants affecting how a protein polymer can be utilized in the body.
Mihir, Shah, Pang-Yu, Hsueh, Guoyong, Sun, Ho Yon, Chang, Siti M, Janib, J Andrew, MacKay   +5 more
openaire   +2 more sources

Elastin-like polypeptides in drug delivery [PDF]

Advanced Drug Delivery Reviews, 2016
The use of recombinant elastin-like materials, or elastin-like recombinamers (ELRs), in drug-delivery applications is reviewed in this work. Although ELRs were initially used in similar ways to other, more conventional kinds of polymeric carriers, their unique properties soon gave rise to systems of unparalleled functionality and efficiency, with the ...
Rodríguez Cabello, José Carlos, Arias Vallejo, Francisco Javier, Alonso Rodrigo, Matilde, Girotti ., Alessandra   +3 more
openaire   +2 more sources

Chain Stiffness of Elastin-Like Polypeptides [PDF]

Biomacromolecules, 2010
The hydrodynamic radii of a series of genetically engineered monodisperse elastin like polypeptides (ELP) was determined by dynamic light scattering in aqueous solution as function of molar mass. Utilizing the known theoretical expression for the hydrodynamic radius of wormlike chains, the Kuhn statistical segment length was determined to be lk = 2.1 ...
Fluegel, Sabine, Fischer, Karl, McDaniel, Jonathan R, Chilkoti, Ashutosh, Schmidt, Manfred   +4 more
openaire   +2 more sources

Elastin-like polypeptides: Therapeutic applications for an emerging class of nanomedicines. [PDF]

J Control Release, 2016
Despanie J, Dhandhukia JP, Hamm-Alvarez SF, MacKay JA.   +3 more
europepmc   +2 more sources

Application of Elastin-like Polypeptide in Tumor Therapy

Cancers, 2022
Elastin-like polypeptides (ELPs) are stimulus-responsive artificially designed proteins synthesized from the core amino acid sequence of human tropoelastin. ELPs have good biocompatibility and biodegradability and do not systemically induce adverse immune responses, making them a suitable module for drug delivery.
Xianggang Shi, Dongfeng Chen, Guodong Liu, Hailing Zhang, Xiaoyan Wang, Zhi Wu, Yan Wu, Feng Yu, Qinggang Xu   +8 more
openaire   +2 more sources

Generation of a Monoclonal Antibody to Detect Elastin-like Polypeptides. [PDF]

Biomacromolecules, 2019
The identification and use of antibodies dominate the biologic, clinical diagnostic, and therapeutic landscapes. In particular, antibodies have become essential tools in a variety of protein analytical experiments and to study the disposition of biologic therapeutics.
Kouhi A, Yao Z, Zheng L, Li Z, Hu P, Epstein AL, MacKay JA.   +6 more
europepmc   +4 more sources

Elastin-like polypeptides as models of intrinsically disordered proteins. [PDF]

FEBS Lett, 2015
Elastin‐like polypeptides (ELPs) are a class of stimuli‐responsive biopolymers inspired by the intrinsically disordered domains of tropoelastin that are composed of repeats of the VPGXG pentapeptide motif, where X is a “guest residue”. They undergo a reversible, thermally triggered lower critical solution temperature (LCST) phase transition, which has ...
Roberts S, Dzuricky M, Chilkoti A.
europepmc   +4 more sources

Corneal Penetrating Elastin-Like Polypeptide Carriers [PDF]

Journal of Ocular Pharmacology and Therapeutics, 2016
Elastin-like polypeptide (ELP) is a bioengineered protein widely applied as a drug carrier due to its biocompatibility and amenability to modification with cell-penetrating peptides (CPPs) and therapeutic agents. The purpose of this study was to determine whether topically applied ELP or CPP-fused ELPs penetrate the corneal barrier.In vitro binding and
Eric M, George, Fakhri, Mahdi, Omar C, Logue, Grant G, Robinson, Gene L, Bidwell   +4 more
openaire   +2 more sources