Novel hemostatic biomolecules based on elastin-like polypeptides and the self-assembling peptide RADA-16 [PDF]
BMC Biotechnology, 2018 Background Safe and effective hemostatic materials are important for reducing mortality resulting from excessive hemorrhage. In this work, new biomaterials with hemostatic effects were created by fusing the gene coding for RADA-16, a self-assembling ...
Shasha Yang +8 more
doaj +2 more sources
Effect of detergents on the thermal behavior of elastin-like polypeptides. [PDF]
Biopolymers, 2013 AbstractElastin‐like polypeptide (ELP) fusions have been designed to allow large‐scale, nonchromatographic purification of many soluble proteins by using the inverse transition cycling (ITC) method; however, the sensitivity of the aqueous lower critical solubility phase transition temperature (Tt) of ELPs to the addition of cosolutes, including ...
Thapa A +5 more
europepmc +4 more sources
Refining the Design of Diblock Elastin-Like Polypeptides for Self-Assembly into Nanoparticles [PDF]
Polymers, 2021 Bertrand Garbay +2 more
exaly +2 more sources
One-Pot Synthesis of Multiple Stimuli-Responsive Magnetic Nanomaterials Based on the Biomineralization of Elastin-like Polypeptides [PDF]
ACS Omega, 2021 Yanhong Zhou +4 more
doaj +2 more sources
Engineering the Architecture of Elastin‐Like Polypeptides: From Unimers to Hierarchical Self‐Assembly [PDF]
Advanced Therapeutics, 2020 Stefan Roberts +2 more
exaly +2 more sources
Frontiers in Materials, 2021 Porous biomaterials are of significant interest in a variety of biomedical applications as they enable the diffusion of nutrients and gases as well as the removal of metabolic waste from implants.
Lubinda Mbundi +5 more
doaj +1 more source
Biodegradation of elastin‐like polypeptide nanoparticles [PDF]
Protein Science, 2012 AbstractProtein polymers are repetitive polypeptides produced by ribosomal biosynthetic pathways; furthermore, they offer emerging opportunities in drug and biopharmaceutical delivery. As for any polymer, biodegradation is one of the most important determinants affecting how a protein polymer can be utilized in the body.
Mihir, Shah +5 more
openaire +2 more sources
Pathway‐Dependent Co‐Assembly of Elastin‐Like Polypeptides [PDF]
Small, 2021 AbstractIn natural systems, temperature‐induced assembly of biomolecules can lead to the formation of distinct assembly states, created out of the same set of starting compounds, based on the heating trajectory followed. Until now it has been difficult to achieve similar behavior in synthetic polymer mixtures.
Jan Pille +8 more
openaire +2 more sources
Elastin-like polypeptides in drug delivery [PDF]
Advanced Drug Delivery Reviews, 2016 The use of recombinant elastin-like materials, or elastin-like recombinamers (ELRs), in drug-delivery applications is reviewed in this work. Although ELRs were initially used in similar ways to other, more conventional kinds of polymeric carriers, their unique properties soon gave rise to systems of unparalleled functionality and efficiency, with the ...
Rodríguez Cabello, José Carlos +3 more
openaire +2 more sources
Chain Stiffness of Elastin-Like Polypeptides [PDF]
Biomacromolecules, 2010 The hydrodynamic radii of a series of genetically engineered monodisperse elastin like polypeptides (ELP) was determined by dynamic light scattering in aqueous solution as function of molar mass. Utilizing the known theoretical expression for the hydrodynamic radius of wormlike chains, the Kuhn statistical segment length was determined to be lk = 2.1 ...
Fluegel, Sabine +4 more
openaire +2 more sources