Results 21 to 30 of about 6,079 (163)
Novel Protein Therapeutics Created Using the Elastin-Like Polypeptide Platform
Physiology, 2021 Gene L Bidwell
exaly +2 more sources
Elastin-Like Polypeptides for Biomedical Applications [PDF]
Annual Review of Biomedical Engineering, 2020 Elastin-like polypeptides (ELPs) are stimulus-responsive biopolymers derived from human elastin. Their unique properties—including lower critical solution temperature phase behavior and minimal immunogenicity—make them attractive materials for a variety of biomedical applications.
Anastasia K, Varanko +2 more
openaire +2 more sources
Cell-Penetrating Doxorubicin Released from Elastin-Like Polypeptide Kills Doxorubicin-Resistant Cancer Cells in In Vitro Study [PDF]
International Journal of Molecular Sciences, 2021 Jung Su Ryu +2 more
exaly +2 more sources
Biodegradation of elastin‐like polypeptide nanoparticles [PDF]
Protein Science, 2012 AbstractProtein polymers are repetitive polypeptides produced by ribosomal biosynthetic pathways; furthermore, they offer emerging opportunities in drug and biopharmaceutical delivery. As for any polymer, biodegradation is one of the most important determinants affecting how a protein polymer can be utilized in the body.
Mihir, Shah +5 more
openaire +2 more sources
Pathway‐Dependent Co‐Assembly of Elastin‐Like Polypeptides [PDF]
Small, 2021 AbstractIn natural systems, temperature‐induced assembly of biomolecules can lead to the formation of distinct assembly states, created out of the same set of starting compounds, based on the heating trajectory followed. Until now it has been difficult to achieve similar behavior in synthetic polymer mixtures.
Jan Pille +8 more
openaire +2 more sources
Construction and application of elastin like polypeptide containing IL-4 receptor targeting peptide. [PDF]
PLoS ONE, 2013 Various human solid tumors highly express IL-4 receptors which amplify the expression of some of anti-apoptotic proteins, preventing drug-induced cancer cell death. Thus, IL-4 receptor targeted drug delivery can possibly increase the therapeutic efficacy
Vijaya Sarangthem +8 more
doaj +1 more source
Elastin-like polypeptides in drug delivery [PDF]
Advanced Drug Delivery Reviews, 2016 The use of recombinant elastin-like materials, or elastin-like recombinamers (ELRs), in drug-delivery applications is reviewed in this work. Although ELRs were initially used in similar ways to other, more conventional kinds of polymeric carriers, their unique properties soon gave rise to systems of unparalleled functionality and efficiency, with the ...
Rodríguez Cabello, José Carlos +3 more
openaire +2 more sources
Chain Stiffness of Elastin-Like Polypeptides [PDF]
Biomacromolecules, 2010 The hydrodynamic radii of a series of genetically engineered monodisperse elastin like polypeptides (ELP) was determined by dynamic light scattering in aqueous solution as function of molar mass. Utilizing the known theoretical expression for the hydrodynamic radius of wormlike chains, the Kuhn statistical segment length was determined to be lk = 2.1 ...
Fluegel, Sabine +4 more
openaire +2 more sources
Applications of elastin-like polypeptides in drug delivery [PDF]
Journal of Controlled Release, 2014 Elastin-like polypeptides (ELPs) are biopolymers inspired by human elastin. Their lower critical solution temperature phase transition behavior and biocompatibility make them useful materials for stimulus-responsive applications in biological environments.
Sarah R, MacEwan, Ashutosh, Chilkoti
openaire +2 more sources
Journal of Nanobiotechnology, 2023 Elastin-like polypeptides (ELPs) are thermally responsive biopolymers derived from natural elastin. These peptides have a low critical solution temperature phase behavior and can be used to prepare stimuli-responsive biomaterials.
Yingshu Guo +4 more
doaj +1 more source