Application of bioengineered elastin-like polypeptide-based system for targeted gene delivery in tumor cells [PDF]
Biomaterials and Biosystems, 2022 Successful gene delivery depends on the entry of negatively charged DNAs and oligonucleotides across the various barriers of the tumor cells and localization into the nucleus for its transcription and protein translation. Here, we have reported a thermal
Aena Yi +4 more
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Development of elastin-like polypeptide for targeted specific gene delivery in vivo [PDF]
Journal of Nanobiotechnology, 2020 Background The successful deliveries of siRNA depend on their stabilities under physiological conditions because greater in vivo stability enhances cellular uptake and enables endosomal escape. Viral-based systems appears as most efficient approaches for
Aena Yi +4 more
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Elastin-like polypeptide delivery of anti-inflammatory peptides to the brain following ischemic stroke. [PDF]
FASEB J, 2023 Inflammatory processes are activated following ischemic stroke that lead to increased tissue damage for weeks following the ischemic insult, but there are no approved therapies that target this inflammation‐induced secondary injury.
Howell JA +5 more
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Robust Photocontrol of Elastin-like Polypeptide Phase Transition with a Genetically Encoded Arylazopyrazole. [PDF]
ACS Synth Biol, 2023 The rational design of light-responsive proteins and protein-based polymers requires both a photoswitch with suitable light-responsive properties and the ability to incorporate it at (multiple) defined positions in the protein chain.
Strugach DS, Hadar D, Amiram M.
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The Internal Structural Dynamics of Elastin-Like Polypeptide Assemblies by <sup>13</sup>C-Direct Detected NMR Spectroscopy. [PDF]
Anal ChemElastin-like polypeptides (ELPs) are biocompatible polymers exhibiting lower critical solution temperature (LCST) behavior, making them valuable in various applications, including drug delivery and tissue engineering.
Brandis D, Kadeřávek P, Kurzbach D.
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Extracellular Matrix-Mimetic Hydrogels for Treating Neural Tissue Injury: A Focus on Fibrin, Hyaluronic Acid, and Elastin-Like Polypeptide Hydrogels. [PDF]
Adv Healthc Mater, 2021 Neurological and functional recovery is limited following central nervous system injury and severe injury to the peripheral nervous system. Extracellular matrix (ECM)‐mimetic hydrogels are of particular interest as regenerative scaffolds for the injured ...
Nelson DW, Gilbert RJ.
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Engineered elastin-like polypeptide improves the efficiency of adipose-derived stem cell-mediated cutaneous wound healing in type II diabetes mellitus. [PDF]
Heliyon, 2023 Impaired cutaneous wound healing is a major complication in patients with diabetes mellitus (DM), leading to increased amputation and mortality rates in affected patients.
Woo SH +5 more
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Kidney-specific delivery of a matrix metalloproteinase-2 inhibitory peptide fused to elastin-like polypeptide reduces proteinuria and renal fibrosis in a model of salt-sensitive hypertension. [PDF]
J Pharmacol Exp TherRenal fibrosis is the hallmark and final common pathway of chronic kidney disease. Matrix metalloproteinases (MMPs) are zinc-dependent enzymes that cleave bioactive molecules to maintain extracellular matrix homeostasis.
Akinleye AA +3 more
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Elastin-like polypeptide and triclosan-modified PCL membrane provides aseptic protection in tissue regeneration. [PDF]
Mater Today BioTissue regeneration is a spatiotemporally ordered multidimensional process involving hierarchical structures, vascularization, and metabolic-immune properties, while injury often triggers structural disorganization, inflammation, metabolic dysfunction ...
Peng X +8 more
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Development of an Elastin-like Polypeptide-Based Nucleic Acid Delivery System Targeted to EGFR+ Bladder Cancer Cells Using a Layer-by-Layer Approach. [PDF]
BiomacromoleculesNucleic acid (NA)-based therapies are revolutionizing biomedical research through their ability to control cellular functions at the genetic level. This work demonstrates a versatile elastin-like polypeptide (ELP) carrier system using a layer-by-layer ...
Aayush A +4 more
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