Results 21 to 30 of about 4,594,965 (203)

Bioorthogonal Elastin-like Polypeptide Scaffolds for Immunoassay Enhancement [PDF]

ACS Applied Materials & Interfaces, 2018
Artificial multiprotein complexes are sought after reagents for biomolecular engineering. A current limiting factor is the paucity of molecular scaffolds which allow for site-specific multicomponent assembly.
Michael A. Nash (1486669), Rosario Vanella (4584925), Duy Tien Ta (4584922), Nash, Michael A., Ta, Duy Tien, Michael A. Nash, Vanella, Rosario, Rosario Vanella, Duy Tien Ta   +8 more
core   +6 more sources

pH-Responsive Elastin-Like Polypeptide Designer Condensates. [PDF]

ACS Appl Mater Interfaces, 2023
Biomolecular condensates are macromolecular complexes formed by liquid-liquid phase separation. They regulate key biological functions by reversibly compartmentalizing molecules in cells, in a stimulus-dependent manner. Designing stimuli-responsive synthetic condensates is crucial for engineering compartmentalized synthetic cells that are able to mimic
de Haas RJ, Ganar KA, Deshpande S, de Vries R.   +3 more
europepmc   +3 more sources

Elastin-like Polypeptide-Based Bioink: A Promising Alternative for 3D Bioprinting

, 2021
Three-dimensional (3D) bioprinting offers a great alternative to traditional techniques in tissue reconstruction, based on seeding cells manually into a scaffold, to better reproduce organs’ complexity.
Jean-Philippe Belaïdi (11668197), Michèle Dai, Maïté Rielland (11668200), Sébastien Lecommandoux (1526455), Guillaume Fleury, Jean-Philippe Belaïdi, Michèle Dai (9673730), Elisabeth Garanger, Guillaume Fleury (1500844), Xavier Schultze (9673736), Sébastien Lecommandoux, Xavier Schultze, Maïté Rielland, Elisabeth Garanger (1483138)   +13 more
core   +3 more sources

Pathway‐Dependent Co‐Assembly of Elastin‐Like Polypeptides [PDF]

Small, 2021
AbstractIn natural systems, temperature‐induced assembly of biomolecules can lead to the formation of distinct assembly states, created out of the same set of starting compounds, based on the heating trajectory followed. Until now it has been difficult to achieve similar behavior in synthetic polymer mixtures.
Jan Pille, Antonio Aloi, Duc H. T. Le, Ilia Vialshin, Nathalie van de Laar, Kirsten Kevenaar, Maarten Merkx, Ilja K. Voets, Jan C. M. van Hest   +8 more
openaire   +2 more sources

Elastin-like polypeptides in drug delivery [PDF]

Advanced Drug Delivery Reviews, 2016
The use of recombinant elastin-like materials, or elastin-like recombinamers (ELRs), in drug-delivery applications is reviewed in this work. Although ELRs were initially used in similar ways to other, more conventional kinds of polymeric carriers, their unique properties soon gave rise to systems of unparalleled functionality and efficiency, with the ...
Rodríguez Cabello, José Carlos, Arias Vallejo, Francisco Javier, Alonso Rodrigo, Matilde, Girotti ., Alessandra   +3 more
openaire   +2 more sources

Construction and application of elastin like polypeptide containing IL-4 receptor targeting peptide. [PDF]

PLoS ONE, 2013
Various human solid tumors highly express IL-4 receptors which amplify the expression of some of anti-apoptotic proteins, preventing drug-induced cancer cell death. Thus, IL-4 receptor targeted drug delivery can possibly increase the therapeutic efficacy
Vijaya Sarangthem, Eun A Cho, Sang Mun Bae, Thoudam Debraj Singh, Sun-Ji Kim, Soyoun Kim, Won Bae Jeon, Byung-Heon Lee, Rang-Woon Park   +8 more
doaj   +1 more source

Biodegradation of elastin‐like polypeptide nanoparticles [PDF]

Protein Science, 2012
AbstractProtein polymers are repetitive polypeptides produced by ribosomal biosynthetic pathways; furthermore, they offer emerging opportunities in drug and biopharmaceutical delivery. As for any polymer, biodegradation is one of the most important determinants affecting how a protein polymer can be utilized in the body.
Mihir, Shah, Pang-Yu, Hsueh, Guoyong, Sun, Ho Yon, Chang, Siti M, Janib, J Andrew, MacKay   +5 more
openaire   +2 more sources

Chain Stiffness of Elastin-Like Polypeptides [PDF]

Biomacromolecules, 2010
The hydrodynamic radii of a series of genetically engineered monodisperse elastin like polypeptides (ELP) was determined by dynamic light scattering in aqueous solution as function of molar mass. Utilizing the known theoretical expression for the hydrodynamic radius of wormlike chains, the Kuhn statistical segment length was determined to be lk = 2.1 ...
Fluegel, Sabine, Fischer, Karl, McDaniel, Jonathan R, Chilkoti, Ashutosh, Schmidt, Manfred   +4 more
openaire   +2 more sources

Correlating topography and viscoelastic properties of Elastin-Like Polypeptide scaffolds probed at the nanoscale: Intermodulation Atomic Force Microscopy [PDF]

, 2022
The synthesis and property characterization of soft biomaterials has taken precedence in recent years. Although bulk physical-chemical properties are well known for these bio-materials, nanoscale properties still need to be probed and evaluated to fine ...
Hendrick, deHaan, Mohammad Hassan, Khatami, Samantha, Firman, Nisha Rani, Agarwal, Janani, Balasubramanian, Sebastiano, Trusso   +5 more
core   +1 more source

The construction of elastin-like polypeptides and their applications in drug delivery system and tissue repair

Journal of Nanobiotechnology, 2023
Elastin-like polypeptides (ELPs) are thermally responsive biopolymers derived from natural elastin. These peptides have a low critical solution temperature phase behavior and can be used to prepare stimuli-responsive biomaterials.
Yingshu Guo, Shiwei Liu, Dan Jing, Nianzu Liu, Xiliang Luo   +4 more
doaj   +1 more source