Results 41 to 50 of about 14,557 (201)
The liquid structure of elastin
eLife, 2017 The protein elastin imparts extensibility, elastic recoil, and resilience to tissues including arterial walls, skin, lung alveoli, and the uterus. Elastin and elastin-like peptides are hydrophobic, disordered, and undergo liquid-liquid phase separation ...
Sarah Rauscher, Régis Pomès
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Elastin‐like polypeptides as models of intrinsically disordered proteins [PDF]
FEBS Letters, 2015 Elastin‐like polypeptides (ELPs) are a class of stimuli‐responsive biopolymers inspired by the intrinsically disordered domains of tropoelastin that are composed of repeats of the VPGXG pentapeptide motif, where X is a “guest residue”. They undergo a reversible, thermally triggered lower critical solution temperature (LCST) phase transition, which has ...
Roberts, Stefan +2 more
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, 2022 The synthesis and property characterization of soft biomaterials has taken precedence in recent years. Although bulk physical-chemical properties are well known for these bio-materials, nanoscale properties still need to be probed and evaluated to fine ...
Hendrick, deHaan +5 more
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Emerging Role of Elastin-Like Polypeptides in Regenerative Medicine
Advances in Wound Care, 2021 Significance: Wound dressing based on naturally derived polymer provides a useful platform for treatment of skin injuries. Owing to the high mechanical strength and tunable structural and physicochemical properties of human elastin-like polypeptides (ELPs), they may be used as excellent materials for fabricating
Vijaya, Sarangthem +2 more
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Fusions of Elastin-Like Polypeptides to Pharmaceutical Proteins [PDF]
, 2012 Elastin-like polypeptides (ELPs) are a class of stimulus-responsive biopolymers whose physicochemical properties and biocompatibility are particularly suitable for in vivo applications, such as drug delivery and tissue engineering. The lower critical solution temperature (LCST) behavior of ELPs allows them to be utilized as soluble macromolecules below
Wafa, Hassouneh +2 more
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Biophysical Characterization of an Elastin-Like-Polypeptide [PDF]
Biophysical Journal, 2011 Perhaps the largest impediment in cancer therapies has been the inability to effectively target systemically delivered therapeutics to cancerous cells. A recent and novel approach to this problem has been to chemically conjugate the therapeutic to an Elastin-Like-Polypeptide (ELP).
Lyons, Daniel +4 more
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BioTechniques, 2016 The protocol described here is designed as an extension of existing techniques for creating elastin-like polypeptides. It allows for the expression and purification of elastin-like polypeptide (ELP) constructs that are poorly expressed or have very low ...
Markian S. Bahniuk +2 more
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Evaluation of Elastin-Like Polypeptides for Tumor Targeted Delivery of Doxorubicin to Glioblastoma
Molecules, 2019 To increase treatment efficiency for glioblastoma, we have developed a system to selectively deliver chemotherapeutic doxorubicin (Dox) to Glioblastoma (GBM) tumors.
Sonja Dragojevic +2 more
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The application of elastin-like peptides in cancer, tissue engineering and ocular disease
OpenNano, 2023 Elastin-like polypeptides (ELPs) are macromolecular biopolymers composed of natural amino acids. ELPs can be prepared by genetic engineering so that their amino acid sequences and molecular weight can be precisely manipulated.
Dabo Jiang +7 more
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Facile Formation of Giant Elastin-like Polypeptide Vesicles as Synthetic Cells
, 2021 vesicles that are more robust and stable were developed as a new chassis material for synthetic cells. Here we demonstrate the facile and robust generation of giant peptide vesicles made of elastin-like polypeptides (ELPs) by using an emulsion transfer ...
Bineet, Sharma +5 more
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