Results 41 to 50 of about 44,933 (233)

Elastin-Like Polypeptides for Biomedical Applications [PDF]

Annual Review of Biomedical Engineering, 2020
Elastin-like polypeptides (ELPs) are stimulus-responsive biopolymers derived from human elastin. Their unique properties—including lower critical solution temperature phase behavior and minimal immunogenicity—make them attractive materials for a variety of biomedical applications.
Anastasia K, Varanko, Jonathan C, Su, Ashutosh, Chilkoti   +2 more
openaire   +2 more sources

Pathway‐Dependent Co‐Assembly of Elastin‐Like Polypeptides [PDF]

Small, 2021
AbstractIn natural systems, temperature‐induced assembly of biomolecules can lead to the formation of distinct assembly states, created out of the same set of starting compounds, based on the heating trajectory followed. Until now it has been difficult to achieve similar behavior in synthetic polymer mixtures.
Jan Pille, Antonio Aloi, Duc H. T. Le, Ilia Vialshin, Nathalie van de Laar, Kirsten Kevenaar, Maarten Merkx, Ilja K. Voets, Jan C. M. van Hest   +8 more
openaire   +2 more sources

Biodegradation of elastin‐like polypeptide nanoparticles [PDF]

Protein Science, 2012
AbstractProtein polymers are repetitive polypeptides produced by ribosomal biosynthetic pathways; furthermore, they offer emerging opportunities in drug and biopharmaceutical delivery. As for any polymer, biodegradation is one of the most important determinants affecting how a protein polymer can be utilized in the body.
Mihir, Shah, Pang-Yu, Hsueh, Guoyong, Sun, Ho Yon, Chang, Siti M, Janib, J Andrew, MacKay   +5 more
openaire   +2 more sources

Elastin-like polypeptides in drug delivery [PDF]

Advanced Drug Delivery Reviews, 2016
The use of recombinant elastin-like materials, or elastin-like recombinamers (ELRs), in drug-delivery applications is reviewed in this work. Although ELRs were initially used in similar ways to other, more conventional kinds of polymeric carriers, their unique properties soon gave rise to systems of unparalleled functionality and efficiency, with the ...
Rodríguez Cabello, José Carlos, Arias Vallejo, Francisco Javier, Alonso Rodrigo, Matilde, Girotti ., Alessandra   +3 more
openaire   +2 more sources

Chain Stiffness of Elastin-Like Polypeptides [PDF]

Biomacromolecules, 2010
The hydrodynamic radii of a series of genetically engineered monodisperse elastin like polypeptides (ELP) was determined by dynamic light scattering in aqueous solution as function of molar mass. Utilizing the known theoretical expression for the hydrodynamic radius of wormlike chains, the Kuhn statistical segment length was determined to be lk = 2.1 ...
Fluegel, Sabine, Fischer, Karl, McDaniel, Jonathan R, Chilkoti, Ashutosh, Schmidt, Manfred   +4 more
openaire   +2 more sources

Applications of elastin-like polypeptides in drug delivery [PDF]

Journal of Controlled Release, 2014
Elastin-like polypeptides (ELPs) are biopolymers inspired by human elastin. Their lower critical solution temperature phase transition behavior and biocompatibility make them useful materials for stimulus-responsive applications in biological environments.
Sarah R, MacEwan, Ashutosh, Chilkoti
openaire   +2 more sources

Applications of elastin-like polypeptides in tissue engineering [PDF]

Advanced Drug Delivery Reviews, 2010
Elastin-like polypeptides (ELPs) have found utility in tissue engineering applications, not only because they are biocompatible, biodegradable, and non-immunogenic, but also because their amino acid sequence and molecular weight can be precisely controlled at the genetic or synthetic level, affording exquisite control over final protein functionality ...
Dana L, Nettles, Ashutosh, Chilkoti, Lori A, Setton   +2 more
openaire   +2 more sources

Corneal Penetrating Elastin-Like Polypeptide Carriers [PDF]

Journal of Ocular Pharmacology and Therapeutics, 2016
Elastin-like polypeptide (ELP) is a bioengineered protein widely applied as a drug carrier due to its biocompatibility and amenability to modification with cell-penetrating peptides (CPPs) and therapeutic agents. The purpose of this study was to determine whether topically applied ELP or CPP-fused ELPs penetrate the corneal barrier.In vitro binding and
Eric M, George, Fakhri, Mahdi, Omar C, Logue, Grant G, Robinson, Gene L, Bidwell   +4 more
openaire   +2 more sources

Induction of protein body formation in plant leaves by elastin-like polypeptide fusions

BMC Biology, 2009
Background Elastin-like polypeptides are synthetic biopolymers composed of a repeating pentapeptide 'VPGXG' sequence that are valuable for the simple non-chromatographic purification of recombinant proteins.
Joensuu Jussi J, Conley Andrew J, Menassa Rima, Brandle Jim E   +3 more
doaj   +1 more source

Targeted Drug Delivery Biopolymers Effectively Inhibit Breast Tumor Growth and Prevent Doxorubicin-Induced Cardiotoxicity

Molecules, 2022
The anticancer agent doxorubicin(dox) has been widely used in the treatment of a variety of hematological malignancies and solid tumors. Despite doxorubicin’s efficiency in killing tumor cells, severe damage to healthy tissues, along with cardiotoxicity,
Sonja Dragojevic, Jung Su Ryu, Michael E. Hall, Drazen Raucher   +3 more
doaj   +1 more source