Results 41 to 50 of about 6,079 (163)

Emerging Role of Elastin-Like Polypeptides in Regenerative Medicine

Advances in Wound Care, 2021
Significance: Wound dressing based on naturally derived polymer provides a useful platform for treatment of skin injuries. Owing to the high mechanical strength and tunable structural and physicochemical properties of human elastin-like polypeptides (ELPs), they may be used as excellent materials for fabricating
Vijaya, Sarangthem, Thoudam Debraj, Singh, Amit Kumar, Dinda   +2 more
openaire   +2 more sources

Biophysical Characterization of an Elastin-Like-Polypeptide [PDF]

Biophysical Journal, 2011
Perhaps the largest impediment in cancer therapies has been the inability to effectively target systemically delivered therapeutics to cancerous cells. A recent and novel approach to this problem has been to chemically conjugate the therapeutic to an Elastin-Like-Polypeptide (ELP).
Lyons, Daniel, Bidwell, Gene L., Kramer, Wolfgang H., Raucher, Drazen, Correia, John J.   +4 more
openaire   +1 more source

Evaluation of Elastin-Like Polypeptides for Tumor Targeted Delivery of Doxorubicin to Glioblastoma

Molecules, 2019
To increase treatment efficiency for glioblastoma, we have developed a system to selectively deliver chemotherapeutic doxorubicin (Dox) to Glioblastoma (GBM) tumors.
Sonja Dragojevic, Rebecca Mackey, Drazen Raucher   +2 more
doaj   +1 more source

The application of elastin-like peptides in cancer, tissue engineering and ocular disease

OpenNano, 2023
Elastin-like polypeptides (ELPs) are macromolecular biopolymers composed of natural amino acids. ELPs can be prepared by genetic engineering so that their amino acid sequences and molecular weight can be precisely manipulated.
Dabo Jiang, Yang Yang, Xiuyi Yang, Boxuan Wang, Wenxuan Fan, Yuchen Liu, Xiaofei Xin, Lifang Yin   +7 more
doaj   +1 more source

Aggregation-Dispersion Chromatography: Application of Elastin-like Polypeptides

Separations
Protein purification is a crucial step for various downstream applications like drug development, antibody preparation, and structure determination. The constant pursuit is for methods that are more efficient and cost-effective.
Han Bin Shin, Young Kee Chae
doaj   +1 more source

Influence of elastin-like polypeptide and hydrophobin on recombinant hemagglutinin accumulations in transgenic tobacco plants. [PDF]

PLoS ONE, 2014
Fusion protein strategies are useful tools to enhance expression and to support the development of purification technologies. The capacity of fusion protein strategies to enhance expression was explored in tobacco leaves and seeds.
Hoang Trong Phan, Bettina Hause, Gerd Hause, Elsa Arcalis, Eva Stoger, Daniel Maresch, Friedrich Altmann, Jussi Joensuu, Udo Conrad   +8 more
doaj   +1 more source

Effect of detergents on the thermal behavior of elastin‐like polypeptides [PDF]

Biopolymers, 2012
AbstractElastin‐like polypeptide (ELP) fusions have been designed to allow large‐scale, nonchromatographic purification of many soluble proteins by using the inverse transition cycling (ITC) method; however, the sensitivity of the aqueous lower critical solubility phase transition temperature (Tt) of ELPs to the addition of cosolutes, including ...
Arjun, Thapa, Wei, Han, Robin H, Simons, Ashutosh, Chilkoti, Eva Y, Chi, Gabriel P, López   +5 more
openaire   +2 more sources

Multifunctional elastin-like polypeptide renders β-glucosidase enzyme phase transition and high stability

Biotechnology for Biofuels, 2019
Background In the enzymatic conversion of biomass, it becomes an important issue to efficiently and cost-effectively degrade cellulose into fermentable glucose. β-Glucosidase (Bgluc), an essential member of cellulases, plays a critical role in cellulosic
Yang Zhou, Xiaofeng Li, Dandan Yan, Frank Addai Peprah, Xingqi Ji, Emmanuella Esi Fletcher, Yanwei Wang, Yingying Wang, Jie Gu, Feng Lin, Haifeng Shi   +10 more
doaj   +1 more source

Engineered elastin-like polypeptides: An efficient platform for enhanced cancer treatment

Frontiers in Pharmacology, 2023
Drug delivery systems (DDSs) have recently gained widespread attention for improving drug loading and delivery efficiency in treating many cancers. Elastin-like polypeptides (ELPs) are synthetic peptides derived from a precursor of elastin (tropoelastin),
Aiguo Jiang, Xinqiang Guan, Lianping He, Xingang Guan, Xingang Guan   +4 more
doaj   +1 more source

Extrusion Bioprinting for Wound Healing: Innovations in Functionalized Bioinks and Bioprinting Technology

Advanced Materials Technologies, EarlyView.
Extrusion‐based bioprinting (EBB) has emerged as a versatile biofabrication platform capable of precisely depositing bioinks composed of biomaterials, cells, and bioactive agents to generate patient‐specific, biomimetic skin constructs. This paper presents a state‐of‐the‐art and forward‐looking overview of EBB for wound healing, encompassing printing ...
Hien‐Phuong Le, Anh Tuan Trong Tran, Ammara Waheed, Tran Thanh Tung, Dusan Losic   +4 more
wiley   +1 more source