Results 31 to 40 of about 14,557 (201)
Chain Stiffness of Elastin-Like Polypeptides [PDF]
Biomacromolecules, 2010 The hydrodynamic radii of a series of genetically engineered monodisperse elastin like polypeptides (ELP) was determined by dynamic light scattering in aqueous solution as function of molar mass. Utilizing the known theoretical expression for the hydrodynamic radius of wormlike chains, the Kuhn statistical segment length was determined to be lk = 2.1 ...
Fluegel, Sabine +4 more
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Applications of elastin-like polypeptides in drug delivery [PDF]
Journal of Controlled Release, 2014 Elastin-like polypeptides (ELPs) are biopolymers inspired by human elastin. Their lower critical solution temperature phase transition behavior and biocompatibility make them useful materials for stimulus-responsive applications in biological environments.
Sarah R, MacEwan, Ashutosh, Chilkoti
openaire +2 more sources
Elastin-Based Thermoresponsive Shape-Memory Hydrogels
, 2020 A shape-memory hydrogel is a programmable hydrogel material that can store specific shapes and execute functions in response to stimuli. In this report, we developed shape-memory hydrogels by creating double-network polymeric structures using a ...
Tao Wang (12008) +3 more
core +5 more sources
Applications of elastin-like polypeptides in tissue engineering [PDF]
Advanced Drug Delivery Reviews, 2010 Elastin-like polypeptides (ELPs) have found utility in tissue engineering applications, not only because they are biocompatible, biodegradable, and non-immunogenic, but also because their amino acid sequence and molecular weight can be precisely controlled at the genetic or synthetic level, affording exquisite control over final protein functionality ...
Dana L, Nettles +2 more
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Journal of Nanobiotechnology, 2023 Elastin-like polypeptides (ELPs) are thermally responsive biopolymers derived from natural elastin. These peptides have a low critical solution temperature phase behavior and can be used to prepare stimuli-responsive biomaterials.
Yingshu Guo +4 more
doaj +1 more source
Corneal Penetrating Elastin-Like Polypeptide Carriers [PDF]
Journal of Ocular Pharmacology and Therapeutics, 2016 Elastin-like polypeptide (ELP) is a bioengineered protein widely applied as a drug carrier due to its biocompatibility and amenability to modification with cell-penetrating peptides (CPPs) and therapeutic agents. The purpose of this study was to determine whether topically applied ELP or CPP-fused ELPs penetrate the corneal barrier.In vitro binding and
Eric M, George +4 more
openaire +2 more sources
Advanced Science, 2021 Design of reversible organelle‐like microcompartments formed by liquid–liquid phase separation in cell‐mimicking entities has significantly advanced the bottom‐up construction of artificial eukaryotic cells.
Hang Zhao +5 more
doaj +1 more source
Self-Assembly of Elastin-like Polypeptide Brushes on Silica Surfaces and Nanoparticles. [PDF]
Biomacromolecules, 2021 Control over the placement and activity of biomolecules on solid surfaces is a key challenge in bionanotechnology. While covalent approaches excel in performance, physical attachment approaches excel in ease of processing, which is equally important in ...
Alvisi N +6 more
europepmc +2 more sources
Molecules, 2022 The anticancer agent doxorubicin(dox) has been widely used in the treatment of a variety of hematological malignancies and solid tumors. Despite doxorubicin’s efficiency in killing tumor cells, severe damage to healthy tissues, along with cardiotoxicity,
Sonja Dragojevic +3 more
doaj +1 more source
Elastin-Like Polypeptide Based Hydroxyapatite Bionanocomposites [PDF]
Biomacromolecules, 2011 In nature, organic matrix macromolecules play a critical role in enhancing the mechanical properties of biomineralized composites such as bone and teeth. Designing artificial matrix analogues is promising but challenging because relatively little is known about how natural matrix components function.
Eddie, Wang +2 more
openaire +2 more sources