Results 31 to 40 of about 6,079 (163)

Applications of elastin-like polypeptides in tissue engineering [PDF]

Advanced Drug Delivery Reviews, 2010
Elastin-like polypeptides (ELPs) have found utility in tissue engineering applications, not only because they are biocompatible, biodegradable, and non-immunogenic, but also because their amino acid sequence and molecular weight can be precisely controlled at the genetic or synthetic level, affording exquisite control over final protein functionality ...
Dana L, Nettles, Ashutosh, Chilkoti, Lori A, Setton   +2 more
openaire   +2 more sources

Spatiotemporal Dynamic Assembly/Disassembly of Organelle‐Mimics Based on Intrinsically Disordered Protein‐Polymer Conjugates

Advanced Science, 2021
Design of reversible organelle‐like microcompartments formed by liquid–liquid phase separation in cell‐mimicking entities has significantly advanced the bottom‐up construction of artificial eukaryotic cells.
Hang Zhao, Emmanuel Ibarboure, Vusala Ibrahimova, Ye Xiao, Elisabeth Garanger, Sébastien Lecommandoux   +5 more
doaj   +1 more source

Induction of protein body formation in plant leaves by elastin-like polypeptide fusions

BMC Biology, 2009
Background Elastin-like polypeptides are synthetic biopolymers composed of a repeating pentapeptide 'VPGXG' sequence that are valuable for the simple non-chromatographic purification of recombinant proteins.
Joensuu Jussi J, Conley Andrew J, Menassa Rima, Brandle Jim E   +3 more
doaj   +1 more source

The liquid structure of elastin

eLife, 2017
The protein elastin imparts extensibility, elastic recoil, and resilience to tissues including arterial walls, skin, lung alveoli, and the uterus. Elastin and elastin-like peptides are hydrophobic, disordered, and undergo liquid-liquid phase separation ...
Sarah Rauscher, Régis Pomès
doaj   +1 more source

Targeted Drug Delivery Biopolymers Effectively Inhibit Breast Tumor Growth and Prevent Doxorubicin-Induced Cardiotoxicity

Molecules, 2022
The anticancer agent doxorubicin(dox) has been widely used in the treatment of a variety of hematological malignancies and solid tumors. Despite doxorubicin’s efficiency in killing tumor cells, severe damage to healthy tissues, along with cardiotoxicity,
Sonja Dragojevic, Jung Su Ryu, Michael E. Hall, Drazen Raucher   +3 more
doaj   +1 more source

Corneal Penetrating Elastin-Like Polypeptide Carriers [PDF]

Journal of Ocular Pharmacology and Therapeutics, 2016
Elastin-like polypeptide (ELP) is a bioengineered protein widely applied as a drug carrier due to its biocompatibility and amenability to modification with cell-penetrating peptides (CPPs) and therapeutic agents. The purpose of this study was to determine whether topically applied ELP or CPP-fused ELPs penetrate the corneal barrier.In vitro binding and
Eric M, George, Fakhri, Mahdi, Omar C, Logue, Grant G, Robinson, Gene L, Bidwell   +4 more
openaire   +2 more sources

Elastin-Like Polypeptide Based Hydroxyapatite Bionanocomposites [PDF]

Biomacromolecules, 2011
In nature, organic matrix macromolecules play a critical role in enhancing the mechanical properties of biomineralized composites such as bone and teeth. Designing artificial matrix analogues is promising but challenging because relatively little is known about how natural matrix components function.
Eddie, Wang, Sang-Hyuk, Lee, Seung-Wuk, Lee   +2 more
openaire   +2 more sources

Fusions of Elastin-Like Polypeptides to Pharmaceutical Proteins [PDF]

, 2012
Elastin-like polypeptides (ELPs) are a class of stimulus-responsive biopolymers whose physicochemical properties and biocompatibility are particularly suitable for in vivo applications, such as drug delivery and tissue engineering. The lower critical solution temperature (LCST) behavior of ELPs allows them to be utilized as soluble macromolecules below
Wafa, Hassouneh, Sarah R, MacEwan, Ashutosh, Chilkoti   +2 more
openaire   +2 more sources

Elastin‐like polypeptides as models of intrinsically disordered proteins [PDF]

FEBS Letters, 2015
Elastin‐like polypeptides (ELPs) are a class of stimuli‐responsive biopolymers inspired by the intrinsically disordered domains of tropoelastin that are composed of repeats of the VPGXG pentapeptide motif, where X is a “guest residue”. They undergo a reversible, thermally triggered lower critical solution temperature (LCST) phase transition, which has ...
Roberts, Stefan, Dzuricky, Michael, Chilkoti, Ashutosh   +2 more
openaire   +2 more sources

High-yield recombinant expression and purification of marginally soluble, short elastin-like polypeptides

BioTechniques, 2016
The protocol described here is designed as an extension of existing techniques for creating elastin-like polypeptides. It allows for the expression and purification of elastin-like polypeptide (ELP) constructs that are poorly expressed or have very low ...
Markian S. Bahniuk, Abdullah K. Alshememry, Larry D. Unsworth   +2 more
doaj   +1 more source