Results 31 to 40 of about 4,594,965 (203)
Advanced Science, 2021 Design of reversible organelle‐like microcompartments formed by liquid–liquid phase separation in cell‐mimicking entities has significantly advanced the bottom‐up construction of artificial eukaryotic cells.
Hang Zhao +5 more
doaj +1 more source
Corneal Penetrating Elastin-Like Polypeptide Carriers [PDF]
Journal of Ocular Pharmacology and Therapeutics, 2016 Elastin-like polypeptide (ELP) is a bioengineered protein widely applied as a drug carrier due to its biocompatibility and amenability to modification with cell-penetrating peptides (CPPs) and therapeutic agents. The purpose of this study was to determine whether topically applied ELP or CPP-fused ELPs penetrate the corneal barrier.In vitro binding and
Eric M, George +4 more
openaire +2 more sources
The liquid structure of elastin
eLife, 2017 The protein elastin imparts extensibility, elastic recoil, and resilience to tissues including arterial walls, skin, lung alveoli, and the uterus. Elastin and elastin-like peptides are hydrophobic, disordered, and undergo liquid-liquid phase separation ...
Sarah Rauscher, Régis Pomès
doaj +1 more source
Molecules, 2022 The anticancer agent doxorubicin(dox) has been widely used in the treatment of a variety of hematological malignancies and solid tumors. Despite doxorubicin’s efficiency in killing tumor cells, severe damage to healthy tissues, along with cardiotoxicity,
Sonja Dragojevic +3 more
doaj +1 more source
Changes in the physical structure and chain dynamics of elastin network in homocysteine-cultured arteries [PDF]
, 2009 The thermal and dielectric properties of the elastin network were investigated in arteries cultured with physiological and pathological concentrations of homocysteine, an aminoacid responsible of histological impairments in human arteries.
Lamy, Edouard +6 more
core +1 more source
Applications of elastin-like polypeptides in tissue engineering [PDF]
Advanced Drug Delivery Reviews, 2010 Elastin-like polypeptides (ELPs) have found utility in tissue engineering applications, not only because they are biocompatible, biodegradable, and non-immunogenic, but also because their amino acid sequence and molecular weight can be precisely controlled at the genetic or synthetic level, affording exquisite control over final protein functionality ...
Dana L, Nettles +2 more
openaire +2 more sources
Facile Formation of Giant Elastin-like Polypeptide Vesicles as Synthetic Cells [PDF]
, 2021 vesicles that are more robust and stable were developed as a new chassis material for synthetic cells. Here we demonstrate the facile and robust generation of giant peptide vesicles made of elastin-like polypeptides (ELPs) by using an emulsion transfer ...
Bineet, Sharma +5 more
core +3 more sources
Elastin-Like Polypeptide Based Hydroxyapatite Bionanocomposites [PDF]
Biomacromolecules, 2011 In nature, organic matrix macromolecules play a critical role in enhancing the mechanical properties of biomineralized composites such as bone and teeth. Designing artificial matrix analogues is promising but challenging because relatively little is known about how natural matrix components function.
Eddie, Wang +2 more
openaire +2 more sources
Fusions of Elastin-Like Polypeptides to Pharmaceutical Proteins [PDF]
, 2012 Elastin-like polypeptides (ELPs) are a class of stimulus-responsive biopolymers whose physicochemical properties and biocompatibility are particularly suitable for in vivo applications, such as drug delivery and tissue engineering. The lower critical solution temperature (LCST) behavior of ELPs allows them to be utilized as soluble macromolecules below
Wafa, Hassouneh +2 more
openaire +2 more sources
Elastin‐like polypeptides as models of intrinsically disordered proteins [PDF]
FEBS Letters, 2015 Elastin‐like polypeptides (ELPs) are a class of stimuli‐responsive biopolymers inspired by the intrinsically disordered domains of tropoelastin that are composed of repeats of the VPGXG pentapeptide motif, where X is a “guest residue”. They undergo a reversible, thermally triggered lower critical solution temperature (LCST) phase transition, which has ...
Roberts, Stefan +2 more
openaire +2 more sources