Solution behavior and encapsulation properties of fatty acid-elastin-like polypeptide conjugates. [PDF]
RSC Adv, 2023 Developing new biomaterials is an active research area owing to their applications in regenerative medicine, tissue engineering and drug delivery. Elastin-like polypeptides (ELPs) are good candidates for these applications because they are biosourced ...
Zhang T +7 more
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αB-Crystallin Peptide Fused with Elastin-like Polypeptide: Intracellular Activity in Retinal Pigment Epithelial Cells Challenged with Oxidative Stress. [PDF]
Antioxidants (Basel), 2023 Background: Oxidative stress-induced retinal degeneration is among the main contributing factors of serious ocular pathologies that can lead to irreversible blindness.
Attia SA +11 more
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In situ formed depot of elastin-like polypeptide-hirudin fusion protein for long-acting antithrombotic therapy. [PDF]
Proc Natl Acad Sci U S ASignificance Anticoagulant drugs used in clinics for the prevention of thrombosis are subject to frequent administration and risk of bleeding complications. In this study, we present a long-acting and safe antithrombotic treatment strategy by integrating
Tian X +7 more
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Circumventing Doxorubicin Resistance Using Elastin-like Polypeptide Biopolymer-Mediated Drug Delivery. [PDF]
Int J Mol Sci, 2022 Although doxorubicin (dox), an anthracycline antibiotic, is widely used and effective in treating cancer, its treatment efficiency is limited by low blood plasma solubility, poor pharmacokinetics, and adverse side effects, including irreversible ...
Dragojevic S, Turner L, Raucher D.
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Membrane-based inverse-transition purification facilitates a rapid isolation of various spider-silk elastin-like polypeptide fusion proteins from extracts of transgenic tobacco. [PDF]
Transgenic ResPlants can produce complex pharmaceutical and technical proteins. Spider silk proteins are one example of the latter and can be used, for example, as compounds for high-performance textiles or wound dressings.
Gruchow HM, Opdensteinen P, Buyel JF.
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Targeted elastin-like polypeptide fusion protein for near-infrared imaging of human and canine urothelial carcinoma. [PDF]
Oncotarget, 2022 Cystoscopic visualization of bladder cancer is an essential method for initial bladder cancer detection and diagnosis, transurethral resection, and monitoring for recurrence. We sought to develop a new intravesical imaging agent that is more specific and
Aayush A +9 more
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Two-step purification of elastin-like polypeptide-fusion superoxide dismutase via hydrophobicity and thermoresponsiveness [PDF]
Frontiers in Bioengineering and BiotechnologyIntroductionSuperoxide dismutase (SOD) catalyzes the dismutation of superoxide radicals to oxygen and hydrogen peroxide, serving as a key antioxidant enzyme with important therapeutic and industrial applications.
Weiwei Wang +12 more
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Self-assembled elastin-like polypeptide fusion protein coacervates as competitive inhibitors of advanced glycation end-products enhance diabetic wound healing. [PDF]
J Control Release, 2021 Chronic and non-healing skin wounds are some of the most significant complications in patients with advanced diabetes. A contributing mechanism to this pathology is the non-enzymatic glycation of proteins due to hyperglycemia, leading to the formation of
Kang HJ +7 more
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Bet v 1-displaying elastin-like polypeptide nanoparticles induce a strong humoral and weak CD4+ T-cell response against Bet v 1 in a murine immunogenicity model. [PDF]
Front Immunol, 2022 There is growing concern about the toxicity of colloidal aluminum salts used as adjuvants in subcutaneous allergen immunotherapy (SCIT). Therefore, alternative adjuvants and delivery systems are being explored to replace alum in SCIT. We applied micellar
van Strien J +14 more
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Investigation of characteristics as endodontic sealer of novel experimental elastin-like polypeptide-based mineral trioxide aggregate [PDF]
Scientific Reports, 2021 Although mineral trioxide aggregates (MTA) have been adopted as an endodontic sealer because of excellent sealing effect and bioactive property and been modified with improvement of its characteristics, the developed MTA sealers have not yet satisfied ...
Hyun-Jung Kim +2 more
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