Multifunctional elastin-like polypeptide nanocarriers for efficient miRNA delivery in cancer therapy [PDF]
Journal of NanobiotechnologyBackground The exogenous delivery of miRNA to mimic and restore miRNA-34a activity in various cancer models holds significant promise in cancer treatment.
Jisan Hong +4 more
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Application of bioengineered elastin-like polypeptide-based system for targeted gene delivery in tumor cells [PDF]
Biomaterials and Biosystems, 2022 Successful gene delivery depends on the entry of negatively charged DNAs and oligonucleotides across the various barriers of the tumor cells and localization into the nucleus for its transcription and protein translation. Here, we have reported a thermal
Aena Yi +4 more
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A highly-sensitive genetically encoded temperature indicator exploiting a temperature-responsive elastin-like polypeptide [PDF]
Scientific Reports, 2021 Genetically encoded temperature indicators (GETIs) allow for real-time measurement of subcellular temperature dynamics in live cells. However, GETIs have suffered from poor temperature sensitivity, which may not be sufficient to resolve small heat ...
Cong Quang Vu +3 more
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Development of elastin-like polypeptide for targeted specific gene delivery in vivo [PDF]
Journal of Nanobiotechnology, 2020 Background The successful deliveries of siRNA depend on their stabilities under physiological conditions because greater in vivo stability enhances cellular uptake and enables endosomal escape. Viral-based systems appears as most efficient approaches for
Aena Yi +4 more
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Investigation of characteristics as endodontic sealer of novel experimental elastin-like polypeptide-based mineral trioxide aggregate [PDF]
Scientific Reports, 2021 Although mineral trioxide aggregates (MTA) have been adopted as an endodontic sealer because of excellent sealing effect and bioactive property and been modified with improvement of its characteristics, the developed MTA sealers have not yet satisfied ...
Hyun-Jung Kim +2 more
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Targeted paclitaxel delivery in ovarian cancer via AP1-functionalized elastin-like polypeptide nanocarriers: development and characterization [PDF]
BMC CancerPaclitaxel has been a cornerstone of ovarian cancer chemotherapy for over two decades. However, its clinical application is constrained by poor solubility and non-specific delivery, resulting in systemic toxicity and inconsistent therapeutic outcomes ...
Ridhima Goel +6 more
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Solvent Properties of Water in Aqueous Solutions of Elastin-Like Polypeptide [PDF]
International Journal of Molecular Sciences, 2015 The phase-transition temperatures of an elastin-like polypeptide (ELP) with the (GVGVP)40 sequence and solvent dipolarity/polarizability, hydrogen-bond donor acidity, and hydrogen-bond acceptor basicity in its aqueous solutions were quantified in the absence and presence of different salts (Na2SO4, NaCl, NaClO4, and NaSCN) and various osmolytes ...
Nolan Holland +2 more
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An Elastin-like Polypeptide-fusion peptide targeting capsid-tegument interface as an antiviral against cytomegalovirus infection [PDF]
Scientific ReportsThe tegument protein pp150 of Human Cytomegalovirus (HCMV) is known to be essential for the final stages of virus maturation and mediates its functions by interacting with capsid proteins.
Komal Beeton +6 more
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Molecules, 2009 A well characterized, peptide derivative of bovine lactoferrin, L12, has been shown to possess anticancer properties in multiple cell lines. However, adverse side effects in normal tissues and poor plasma kinetics that hinder the clinical effectiveness ...
Emily Thomas +2 more
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Circumventing Doxorubicin Resistance Using Elastin-like Polypeptide Biopolymer-Mediated Drug Delivery [PDF]
International Journal of Molecular Sciences, 2022 Dražen Raucher, Raucher Dražen
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