Therapeutic Effect of IL-4 Receptor-Targeting Pro-Apoptotic Peptide (AP1-ELP-KLAK) in Glioblastoma Tumor Model [PDF]
International Journal of Nanomedicine, 2021 Vijaya Sarangthem,1,2,* Aena Yi,1,* Yunjae Kim,1 Alnawaz Rehemtulla,3 Byung-Heon Lee,1 Young Hyun Jeon,4 Thoudam Debraj Singh,5 Rang-Woon Park1 1Department of Biochemistry and Cell Biology, School of Medicine, and Cell & Matrix Research Institute,
Sarangthem V +7 more
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The evolution of IL-4 and IL-13 and their receptor subunits [PDF]
Cytokine, 2015 Peer ...
Secombes, Christopher J., Wang, Tiehui
core +4 more sources
IFN-γ, IL-4 and IL-13 modulate responsiveness of human airway smooth muscle cells to IL-13 [PDF]
Respiratory Research, 2008 Background IL-13 is a critical mediator of allergic asthma and associated airway hyperresponsiveness. IL-13 acts through a receptor complex comprised of IL-13Rα1 and IL-4Rα subunits with subsequent activation of signal transducer and activator of ...
Michoud Marie-Claire +6 more
doaj +6 more sources
Reduced interleukin-4 receptor α expression on CD8+ T cells correlates with higher quality anti-viral immunity. [PDF]
PLoS ONE, 2013 With the hope of understanding how interleukin (IL)-4 and IL-13 modulated quality of anti-viral CD8(+) T cells, we evaluated the expression of receptors for these cytokines following a range of viral infections (e.g.
Danushka K Wijesundara +3 more
doaj +2 more sources
A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor [PDF]
BMC Biology, 2006 Background Interleukin 4 (IL-4) is a key regulator of the immune system and an important factor in the development of allergic hypersensitivity. Together with interleukin 13 (IL-13), IL-4 plays an important role in exacerbating allergic and asthmatic ...
Sebald Walter +6 more
doaj +3 more sources
THE IL-4 RECEPTOR: Signaling Mechanisms and Biologic Functions [PDF]
Annual Review of Immunology, 1999 ▪ Abstract Interleukin-4 is a multifunctional cytokine that plays a critical role in the regulation of immune responses. Its effects depend upon binding to and signaling through a receptor complex consisting of the IL-4Rα chain and the common gamma chain (γc), resulting in a series of phosphorylation events mediated by receptor-associated kinases.
Achsah Keegan, Jose Zamorano
exaly +4 more sources
Rocaglamide Suppresses Allergic Reactions by Regulating IL-4 Receptor Signaling [PDF]
MoleculesRocaglamide (Roc-A), a natural phytochemical isolated from Aglaia species, is known to exert anticancer effects. Allergic inflammation can enhance the tumorigenic potential of cancer cells. We hypothesized that Roc-A could regulate allergic inflammation.
Hyein Jo +7 more
doaj +2 more sources
Risk of Necrotizing Enterocolitis Associated With the Single Nucleotide Polymorphisms VEGF C-2578A, IL-18 C-607A, and IL-4 Receptor α-Chain A-1902G: A Validation Study in a Prospective Multicenter Cohort [PDF]
Frontiers in Pediatrics, 2020 The etiology of necrotizing enterocolitis (NEC) is multifactorial and an underlying genetic predisposition to NEC is increasingly being recognized. A growing number of studies identified single nucleotide polymorphisms (SNPs) of selected genes with ...
Rob M. Moonen +6 more
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IL-4 receptor polymorphisms predict reduction in asthma exacerbations during response to an anti-IL-4 receptor α antagonist. [PDF]
J Allergy Clin Immunol, 2012 This is the first large pharmacogenetic investigation of the inflammatory IL-4/IL-13 pathway in patients with moderate-to-severe asthma. We analyzed genomic DNA from participants in a 12-week placebo-controlled efficacy trial of pitrakinra (1, 3, or 10 mg twice daily), a novel IL-4/IL-13 pathway antagonist (Clinicaltrials.govNCT00801853).The primary ...
Slager RE +7 more
europepmc +4 more sources
CD300f associates with IL-4 receptor α and amplifies IL-4-induced immune cell responses. [PDF]
Proc Natl Acad Sci U S A, 2015 SignificanceIL-4 receptor (R) α is a critical component in IL-4– and IL-13–mediated signaling and subsequent effector functions such as those observed in allergy. Thus, it is a primary therapeutic target in diseases such as atopic dermatitis and asthma.
Moshkovits I +12 more
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