Therapeutic Effect of IL-4 Receptor-Targeting Pro-Apoptotic Peptide (AP1-ELP-KLAK) in Glioblastoma Tumor Model [PDF]
International Journal of Nanomedicine, 2021 Vijaya Sarangthem,1,2,* Aena Yi,1,* Yunjae Kim,1 Alnawaz Rehemtulla,3 Byung-Heon Lee,1 Young Hyun Jeon,4 Thoudam Debraj Singh,5 Rang-Woon Park1 1Department of Biochemistry and Cell Biology, School of Medicine, and Cell & Matrix Research Institute,
Sarangthem V +7 more
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Rocaglamide Suppresses Allergic Reactions by Regulating IL-4 Receptor Signaling [PDF]
MoleculesRocaglamide (Roc-A), a natural phytochemical isolated from Aglaia species, is known to exert anticancer effects. Allergic inflammation can enhance the tumorigenic potential of cancer cells. We hypothesized that Roc-A could regulate allergic inflammation.
Hyein Jo +7 more
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Risk of Necrotizing Enterocolitis Associated With the Single Nucleotide Polymorphisms VEGF C-2578A, IL-18 C-607A, and IL-4 Receptor α-Chain A-1902G: A Validation Study in a Prospective Multicenter Cohort [PDF]
Frontiers in Pediatrics, 2020 The etiology of necrotizing enterocolitis (NEC) is multifactorial and an underlying genetic predisposition to NEC is increasingly being recognized. A growing number of studies identified single nucleotide polymorphisms (SNPs) of selected genes with ...
Rob M. Moonen +6 more
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Human ADMC-Derived Adipocyte Thermogenic Capacity Is Regulated by IL-4 Receptor [PDF]
Stem Cells International, 2017 Type two innate immune system is anti-inflammatory and may play an important role as the means whereby “browning” is induced in subcutaneous adipocytes. It was shown that IL-4 may influence the fate of adipose cell precursors by promoting differentiation
Fernando Lizcano +3 more
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Association between viral Conjunctivitis and Genetic Polymorphisms related to IL-4 and IL-4R in Egyptian Population [PDF]
Zagazig University Medical Journal, 2022 Background: Viral conjunctivitis is an inflammation of the conjunctiva caused by viruses. Interleukin-4 (IL-4) and IL-4R have been reported to associate with the pathogenesis of conjunctivitis; however, the role of IL-4 and IL-4R genetic polymorphisms in
hala elmesallmy, reda fekry, noha said
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Interleukins 4 and 13 in Asthma: Key Pathophysiologic Cytokines and Druggable Molecular Targets
Frontiers in Pharmacology, 2022 Interleukins (IL)-4 and -13 play a pivotal role in the pathobiology of type-2 asthma. Indeed, IL-4 is crucially involved in Th2 cell differentiation, immunoglobulin (Ig) class switching and eosinophil trafficking.
Corrado Pelaia +8 more
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Cells, 2023 Cytokines secreted by individual immune cells regulate tissue regeneration and allow communication between various cell types. Cytokines bind to cognate receptors and trigger the healing process.
Krisztina Nikovics +6 more
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Transplacental passage of interleukins 4 and 13? [PDF]
PLoS ONE, 2009 The mechanisms by which prenatal events affect development of adult disease are incompletely characterized. Based on findings in a murine model of maternal transmission of asthma risk, we sought to test the role of the pro-asthmatic cytokines interleukin
Robert H Lim, Lester Kobzik
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Acta Dermato-Venereologica, 2020 To evaluate cellular response to oncostatin M (OSM) in comparison to interleukin (IL)-31, we analyzed monocyte chemoattractant protein 1 (MCP-1) as a readout for OSM responses with and without IL-4, IL-13, anti-OSM receptor β monoclonal antibody KPL-716,
Carl D. Richards +4 more
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Dupilumab: basic aspects and applications to T2-mediated diseases
Медицинский совет, 2021 The asthma, chronic rhinosinusitis with nasal polyps (CRSwNP), atopic dermatitis (AD), eosinophilic esophagitis and other diseases based on T2-inflammation are a widespread in the world. It has led to the development of genetically engineered drugs aimed
O. M. Kurbacheva3 +2 more
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