Results 31 to 40 of about 18,323,172 (295)
Expression of the Inhibitory CD200 Receptor Is Associated with Alternative Macrophage Activation [PDF]
, 2010 Classical macrophage activation is inhibited by the CD200 receptor (CD200R). Here, we show that CD200R expression was specifically induced on human in vitro polarized macrophages of the alternatively activated M2a subtype, generated by incubation with IL-
Brouwer, Michael S. M. +17 more
core +1 more source
Gr1+IL-4-producing innate cells are induced in response to Th2 stimuli and suppress Th1-dependent antibody responses [PDF]
, 2008 Alum is used as a vaccine adjuvant and induces T<sub>h</sub>2 responses and T<sub>h</sub>2-driven antibody isotype production against co-injected antigens.
White, Janice +11 more
core +1 more source
IL-13Rα2 is a Glioma-Restricted Receptor for Interleukin-13
Neoplasia: An International Journal for Oncology Research, 2002 We have found that binding sites for interleukin-13. ( IL13) are overexpressed in a vast majority of high-grade astrocytomas. (HGAs). These binding sites for IL-13 are distinct from the physiological receptor in that it does not bind IL-4.
Akiva Mintz +4 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2022 The IL-4/IL-13 axis is involved in the pathogenesis of allergic rhinitis (AR). In this study, we investigated the serum cytokines levels of IL-4, IL-5, IL-6, and IL-13 in AR patients, and the transcript expression levels of their receptors (i.e.
Siti Muhamad Nur Husna +6 more
doaj +1 more source
The role of interleukin-4 receptor alpha on smooth muscle cells during helminth infection [PDF]
, 2011 Includes abstract.Includes bibliographical references (leaves 101-111).Interleukin-4 receptor alpha (IL-4Ra) signaling, mediated by the ligands IL-4 and IL- 13, is important for effective host protection during murine Nippostrongylus brasiliensis (N ...
Brombacher, Tiroyaone M H
core +1 more source
Human osteoarthritic cartilage shows reduced in vivo expression of IL-4, a chondroprotective cytokine that differentially modulates IL-1β-stimulated production of chemokines and matrix-degrading enzymes in vitro. [PDF]
PLoS ONE, 2014 BACKGROUND: In osteoarthritis (OA), an inflammatory environment is responsible for the imbalance between the anabolic and catabolic activity of chondrocytes and, thus, for articular cartilage derangement. This study was aimed at providing further insight
Elisa Assirelli +9 more
doaj +1 more source
Arquivos de Neuro-Psiquiatria, 2007 This study aimed to investigate in a population of Brazilian patients with multiple sclerosis (MS) single-nucleotide polymorphisms (SNP) in the promoter region of IL4 (*33C-T) and receptor IL4R (*Q551R A-G) genes proposed to interfere with disease ...
Thereza Quirico-Santos +5 more
doaj +1 more source
Frontiers in Immunology, 2019 Incorporation of inverted cytokine receptor (ICR) such as interleukin (IL)-4 vs. IL-7 (4/7) ICR is one strategy to improve the antitumor activities of chimeric antigen receptor (CAR) modified T (CAR-T) cells facing immunosuppressive cytokines.
Yi Wang +7 more
doaj +1 more source
Single-Chain Soluble Receptor Fusion Proteins as Versatile Cytokine Inhibitors
Frontiers in Immunology, 2020 Cytokines are small secreted proteins that among many functions also play key roles in the orchestration of inflammation in host defense and disease.
Aurora Holgado +15 more
doaj +1 more source
Vaccines, 2021 We have shown that manipulation of IL-13 and STAT6 signaling at the vaccination site can lead to different innate lymphoid cell (ILC)/dendritic cell (DC) recruitment, resulting in high avidity/poly-functional T cells and effective antibody ...
Zheyi Li, Sreeja Roy, Charani Ranasinghe
doaj +1 more source