Results 31 to 40 of about 1,374,412 (296)
Journal of Neuroinflammation, 2020 Background The existence of referred pain and ectopic paresthesia caused by tooth pulp inflammation may make definitive diagnosis difficult and cause misdiagnosis or mistreatment; thus, elucidation of that molecular mechanism is urgent.
Kohei Kanno +5 more
doaj +1 more source
IL-4 Receptor α Is an Important Modulator of IL-4 and IL-13 Receptor Binding: Implications for the Development of Therapeutic Targets [PDF]
The Journal of Immunology, 2006 Abstract IL-4 is a key cytokine associated with allergy and asthma. Induction of cell signaling by IL-4 involves interaction with its cognate receptors, a complex of IL-4Rα with either the common γ-chain or the IL-13R chain α1 (IL-13Rα1).
Andrews, Allison-Lynn +3 more
openaire +3 more sources
The role of the novel Th17 cytokine IL-26 in intestinal inflammation [PDF]
, 2008 Background and aims: Interleukin 26 (IL-26), a novel IL-10-like cytokine without a murine homologue, is expressed in T helper 1 (Th1) and Th17 cells. Currently, its function in human disease is completely unknown. The aim of this study was to analyse its
Auernhammer, Christoph J. +7 more
core +1 more source
Expression of the Inhibitory CD200 Receptor Is Associated with Alternative Macrophage Activation [PDF]
, 2010 Classical macrophage activation is inhibited by the CD200 receptor (CD200R). Here, we show that CD200R expression was specifically induced on human in vitro polarized macrophages of the alternatively activated M2a subtype, generated by incubation with IL-
Brouwer, Michael S. M. +8 more
core +1 more source
Frontiers in Molecular Biosciences, 2022 The IL-4/IL-13 axis is involved in the pathogenesis of allergic rhinitis (AR). In this study, we investigated the serum cytokines levels of IL-4, IL-5, IL-6, and IL-13 in AR patients, and the transcript expression levels of their receptors (i.e.
Siti Muhamad Nur Husna +6 more
doaj +1 more source
IL-13Rα2 is a Glioma-Restricted Receptor for Interleukin-13
Neoplasia: An International Journal for Oncology Research, 2002 We have found that binding sites for interleukin-13. ( IL13) are overexpressed in a vast majority of high-grade astrocytomas. (HGAs). These binding sites for IL-13 are distinct from the physiological receptor in that it does not bind IL-4.
Akiva Mintz +4 more
doaj +1 more source
Human osteoarthritic cartilage shows reduced in vivo expression of IL-4, a chondroprotective cytokine that differentially modulates IL-1β-stimulated production of chemokines and matrix-degrading enzymes in vitro. [PDF]
PLoS ONE, 2014 BACKGROUND: In osteoarthritis (OA), an inflammatory environment is responsible for the imbalance between the anabolic and catabolic activity of chondrocytes and, thus, for articular cartilage derangement. This study was aimed at providing further insight
Elisa Assirelli +9 more
doaj +1 more source
Immunology, 1997 There has been much recent interest in cytokine expression at the materno–fetal interface. Although T‐helper 2 (Th2)‐type cytokines have been described in the murine feto–placental unit, few studies have as yet been performed in human pregnancy. We have examined the production of interleukin‐4 (IL‐4) and expression of IL‐4 receptors in the human term ...
M I, de Moraes-Pinto +4 more
openaire +4 more sources
Arquivos de Neuro-Psiquiatria, 2007 This study aimed to investigate in a population of Brazilian patients with multiple sclerosis (MS) single-nucleotide polymorphisms (SNP) in the promoter region of IL4 (*33C-T) and receptor IL4R (*Q551R A-G) genes proposed to interfere with disease ...
Thereza Quirico-Santos +5 more
doaj +1 more source
Protein Tyrosine Phosphatase Activity Is Required for IL-4 Induction of IL-4 Receptor α-Chain [PDF]
The Journal of Immunology, 2000 Abstract To investigate the role of protein tyrosine phosphatases in IL-4Rα-chain expression and signaling, we first established that SHP-1, but not SHP-2, coimmunoprecipitated with anti-IL-4Rα chain Abs in extracts prepared from resting lymphocytes.
H, Huang, W E, Paul
openaire +2 more sources