Results 11 to 20 of about 1,374,412 (296)
Human ADMC-Derived Adipocyte Thermogenic Capacity Is Regulated by IL-4 Receptor [PDF]
Stem Cells International, 2017 Type two innate immune system is anti-inflammatory and may play an important role as the means whereby “browning” is induced in subcutaneous adipocytes. It was shown that IL-4 may influence the fate of adipose cell precursors by promoting differentiation
Fernando Lizcano +3 more
doaj +2 more sources
Regulation of IL-4 receptor signaling by STUB1 in lung inflammation. [PDF]
Am J Respir Crit Care Med, 2014 Abstract Rationale IL-4Rα, the common receptor component for IL-4 and IL-13, plays a critical role in IL-4– and IL-13–mediated signaling pathways that regulate airway inflammation and remodeling.
Wei Q +8 more
europepmc +4 more sources
PLoS ONE, 2013 CD4 T cells acquire functional properties including cytokine production upon antigenic stimulation through the T cell receptor (TCR) and differentiate into T helper (Th) cells. Th1 cells produce interferon (IFN)-γ and Th2 cells produce interleukin (IL)-4.
Archna Sharma +3 more
doaj +3 more sources
Inflammatory Dendritic Cells, Regulated by IL-4 Receptor Alpha Signaling, Control Replication, and Dissemination of <i>Leishmania major</i> in Mice. [PDF]
Front Cell Infect Microbiol, 2019 Hurdayal R +3 more
europepmc +3 more sources
Interleukins 4 and 13 in Asthma: Key Pathophysiologic Cytokines and Druggable Molecular Targets
Frontiers in Pharmacology, 2022 Interleukins (IL)-4 and -13 play a pivotal role in the pathobiology of type-2 asthma. Indeed, IL-4 is crucially involved in Th2 cell differentiation, immunoglobulin (Ig) class switching and eosinophil trafficking.
Corrado Pelaia +8 more
doaj +1 more source
Cells, 2023 Cytokines secreted by individual immune cells regulate tissue regeneration and allow communication between various cell types. Cytokines bind to cognate receptors and trigger the healing process.
Krisztina Nikovics +6 more
doaj +1 more source
Involvement of IL-4, IL-13 and Their Receptors in Pancreatic Cancer [PDF]
International Journal of Molecular Sciences, 2021 Interleukin (IL)-4 and IL-13 are known as pleiotropic Th2 cytokines with a wide range of biological properties and functions especially in immune responses. In addition, increasing activities have also been determined in oncogenesis and tumor progression of several malignancies.
Jingwei Shi +4 more
openaire +3 more sources
V75R576 IL-4 Receptor α Is Associated with Allergic Asthma and Enhanced IL-4 Receptor Function [PDF]
The Journal of Immunology, 2002 Abstract Asthma is a complex polygenic disease. Many studies have implicated the importance of IL-4Rα in the development of allergic inflammation and its gene has been implicated in the genetics of asthma and atopy. In this study, we examined the functional consequences of two of the human IL-4Rα allelic variants that have been found to ...
Kimberly A, Risma +7 more
openaire +2 more sources
Enhancement of human IL-4 activity by soluble IL-4 receptorsin vitro [PDF]
European Journal of Immunology, 1999 The recombinant form of the extracellular domain of the IL-4 receptor (sIL-4R) is a potential candidate to neutralize IL-4; however, murine sIL-4R displayed both antagonistic and agonistic activity in vivo. Here we show that human recombinant sIL-4R induced the formation of complexed IL-4 in supernatants of activated T cells in a dose-dependent manner ...
T, Jung +3 more
openaire +2 more sources
Transplacental passage of interleukins 4 and 13? [PDF]
PLoS ONE, 2009 The mechanisms by which prenatal events affect development of adult disease are incompletely characterized. Based on findings in a murine model of maternal transmission of asthma risk, we sought to test the role of the pro-asthmatic cytokines interleukin
Robert H Lim, Lester Kobzik
doaj +1 more source