Results 11 to 20 of about 18,323,172 (295)

A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor [PDF]

BMC Biology, 2006
Background Interleukin 4 (IL-4) is a key regulator of the immune system and an important factor in the development of allergic hypersensitivity. Together with interleukin 13 (IL-13), IL-4 plays an important role in exacerbating allergic and asthmatic ...
Sebald Walter, Nickel Joachim, Harrer Henning, Patiño Edwin, Klein Markus, Kraich Michael, Mueller Thomas D   +6 more
doaj   +6 more sources

IL-4 and IL-4 receptor expression is dispensable for the development and function of natural killer T cells.

PLoS ONE, 2013
CD4 T cells acquire functional properties including cytokine production upon antigenic stimulation through the T cell receptor (TCR) and differentiate into T helper (Th) cells. Th1 cells produce interferon (IFN)-γ and Th2 cells produce interleukin (IL)-4.
Archna Sharma, Rosa Berga-Bolanos, Dil Afroz Sultana, Jyoti Misra Sen   +3 more
doaj   +3 more sources

V75R576 IL-4 Receptor α Is Associated with Allergic Asthma and Enhanced IL-4 Receptor Function [PDF]

The Journal of Immunology, 2002
Abstract Asthma is a complex polygenic disease. Many studies have implicated the importance of IL-4Rα in the development of allergic inflammation and its gene has been implicated in the genetics of asthma and atopy. In this study, we examined the functional consequences of two of the human IL-4Rα allelic variants that have been found to ...
Kimberly A, Risma, Ning, Wang, Ryan P, Andrews, Christie M, Cunningham, Mark B, Ericksen, Jonathan A, Bernstein, Ranajit, Chakraborty, Gurjit K Khurana, Hershey   +7 more
openaire   +2 more sources

Involvement of IL-4, IL-13 and Their Receptors in Pancreatic Cancer [PDF]

International Journal of Molecular Sciences, 2021
Interleukin (IL)-4 and IL-13 are known as pleiotropic Th2 cytokines with a wide range of biological properties and functions especially in immune responses. In addition, increasing activities have also been determined in oncogenesis and tumor progression of several malignancies.
Jingwei Shi, Xujun Song, Benno Traub, Michael Luxenhofer, Marko Kornmann   +4 more
openaire   +3 more sources

BALB/c mice deficient in CD4(+) T cell IL-4R alpha expression control Leishmania mexicana load although female but not male mice develop a healer phenotype [PDF]

, 2011
Immunologically intact BALB/c mice infected with Leishmania mexicana develop non-healing progressively growing lesions associated with a biased Th2 response while similarly infected IL-4R alpha-deficient mice fail to develop lesions and develop a robust ...
Owain R Millington, Bryson Karen J., Millington Owain R., McGachy, Adrienneh H., Brombacher, F, Mokgethi Thabang, Bryson, Karen, H. Adrienne McGachy, Owain R. Millington, McGachy, Adrienne, H Adrienne McGachy, James Alexander, Mokgethi, T, Karen J Bryson, Alexander, James, Brombacher Frank, Frank Brombacher, Alexander James, McGachy, Helen, Bryson, Karen J., Thabang Mokgethi, Millington, Owain R., Millington, Owain, Brombacher, Frank, Mokgethi, Thabang, Bryson, Karen J, Karen J. Bryson, McGachy, H Adrienne, McGachy H. Adrienne, Millington, Owain R   +29 more
core   +4 more sources

IL-4 receptor polymorphisms predict reduction in asthma exacerbations during response to an anti-IL-4 receptor α antagonist. [PDF]

J Allergy Clin Immunol, 2012
This is the first large pharmacogenetic investigation of the inflammatory IL-4/IL-13 pathway in patients with moderate-to-severe asthma. We analyzed genomic DNA from participants in a 12-week placebo-controlled efficacy trial of pitrakinra (1, 3, or 10 mg twice daily), a novel IL-4/IL-13 pathway antagonist (Clinicaltrials.govNCT00801853).The primary ...
Slager RE, Otulana BA, Hawkins GA, Yen YP, Peters SP, Wenzel SE, Meyers DA, Bleecker ER.   +7 more
europepmc   +4 more sources

Novel role for proteinase-activated receptor 2 (PAR2) in membrane trafficking of proteinase-activated receptor 4 (PAR4) [PDF]

, 2012
Proteinase-activated receptors 4 (PAR(4)) is a class A G protein-coupled receptor (GPCR) recognized through the ability of serine proteases such as thrombin and trypsin to mediate receptor activation. Due to the irreversible nature of activation, a fresh
Robben, Joris, Cooke, Alexandra, Gould, Gwyn W., McIntosh, Kathryn A., Gould, Gwyn, Milligan, Graeme, Cunningham, Margaret Rose, Pediani, John D., Cooke, Alexandra E., McIntosh, Kathryn, Nilsson, Mary, Mundell, Stuart, Plevin, Robin, Cunningham, Margaret R., McIntosh, Kathryn A, Pediani, John D, Gould, Gwyn W, Pediani, John, Nilsson, Mary Francis, Cunningham, Margaret R, Cooke, Alexandra E   +20 more
core   +4 more sources

Enhancement of human IL-4 activity by soluble IL-4 receptorsin vitro [PDF]

European Journal of Immunology, 1999
The recombinant form of the extracellular domain of the IL-4 receptor (sIL-4R) is a potential candidate to neutralize IL-4; however, murine sIL-4R displayed both antagonistic and agonistic activity in vivo. Here we show that human recombinant sIL-4R induced the formation of complexed IL-4 in supernatants of activated T cells in a dose-dependent manner ...
T, Jung, K, Wagner, C, Neumann, C H, Heusser   +3 more
openaire   +2 more sources

THE IL-4 RECEPTOR: Signaling Mechanisms and Biologic Functions [PDF]

Annual Review of Immunology, 1999
▪ Abstract  Interleukin-4 is a multifunctional cytokine that plays a critical role in the regulation of immune responses. Its effects depend upon binding to and signaling through a receptor complex consisting of the IL-4Rα chain and the common gamma chain (γc), resulting in a series of phosphorylation events mediated by receptor-associated kinases.
Nelms, Keats, Keegan, Achsah D., Zamorano, José, Ryan, John J., Paul, William E.   +4 more
openaire   +3 more sources

Commentary: IL-4 and IL-13 receptors and signaling [PDF]

Cytokine, 2015
Interleukin (IL)-4 and IL-13 were discovered approximately 30years ago and were immediately linked to allergy and atopic diseases. Since then, new roles for IL-4 and IL-13 and their receptors in normal gestation, fetal development and neurological function and in the pathogenesis of cancer and fibrosis have been appreciated. Studying IL-4/-13 and their
Sarah M, McCormick, Nicola M, Heller
openaire   +2 more sources