Results 21 to 30 of about 18,323,172 (295)

IL-4 receptor mutations

Current Opinion in Immunology, 1999
IL-4 plays an important role in regulating immune responses. Distinct signaling pathways, including those for gene activation and cell differentiation and those for cell proliferation and protection from apoptosis, are initiated from the receptor complex for IL-4 following ligand-receptor engagement. Several advances have been made in our understanding
P Y, Pan, P, Rothman
openaire   +2 more sources

The evolution of IL-4 and IL-13 and their receptor subunits [PDF]

Cytokine, 2015
This review will outline what is known about the origins and evolution of type 2 cytokines and their receptors in vertebrates. It takes advantage of the recent advances made in gene identification from the many vertebrate genomes that have now been sequenced. It will also describe what functional studies have been performed to date, giving clues to the
Wang, Tiehui, Secombes, Christopher J.
openaire   +3 more sources

A case of IgG4-related conjunctival tumor with severe systemic allergy treated with antibodies against cytokine receptors

American Journal of Ophthalmology Case Reports, 2022
Purpose: To present a case of IgG4-related conjunctival tumor in which anti-IL-5 receptor alpha-chain and anti-IL-4 receptor alpha-chain antibodies were administered for eosinophil sinusitis and severe bronchial asthma, but conjunctivitis could not be ...
Atsuki Fukushima, Sachiko Maruoka, Hitoshi Tabuchi   +2 more
doaj   +1 more source

CD300f associates with IL-4 receptor α and amplifies IL-4-induced immune cell responses. [PDF]

Proc Natl Acad Sci U S A, 2015
Significance IL-4 receptor (R) α is a critical component in IL-4– and IL-13–mediated signaling and subsequent effector functions such as those observed in allergy. Thus, it is a primary therapeutic target in diseases such as atopic dermatitis and asthma.
Moshkovits I, Karo-Atar D, Itan M, Reichman H, Rozenberg P, Morgenstern-Ben-Baruch N, Shik D, Ejarque-Ortiz A, Hershko AY, Tian L, Coligan JE, Sayós J, Munitz A.   +12 more
europepmc   +4 more sources

Identification and Characterization of a Novel IL-4 Receptor α Chain (IL-4Rα) Antagonist to Inhibit IL-4 Signalling

Cellular Physiology and Biochemistry, 2015
Background/Aims: In recent times, allergy has become a financial, physical and psychological burden to the society as a whole. In allergic cascades, cytokine IL-4 binds to IL-4 receptor (IL-4R), consequently producing allergen-specific IgE antibodies by ...
Nayyar Ahmed, Pathum Dhanapala, Cenk Suphioglu   +2 more
doaj   +1 more source

Reduced interleukin-4 receptor α expression on CD8+ T cells correlates with higher quality anti-viral immunity. [PDF]

PLoS ONE, 2013
With the hope of understanding how interleukin (IL)-4 and IL-13 modulated quality of anti-viral CD8(+) T cells, we evaluated the expression of receptors for these cytokines following a range of viral infections (e.g.
Danushka K Wijesundara, David C Tscharke, Ronald J Jackson, Charani Ranasinghe   +3 more
doaj   +1 more source

IL-13R alpha 2 reverses the effects of IL-13 and IL-4 on bronchial reactivity and acetylcholine-induced Ca2+ signaling [PDF]

, 2007
Background: The interleukins IL-4 and IL-13 play a key role in the pathophysiology of asthma. The interleukin receptor IL-13R alpha 2 is believed to act as a decoy receptor, but until now, the functional significance of IL-13R alpha 2 remains vague ...
Kellner, Julia, Welsch, Ulrich, Joerres, Rudolf A., Bergner, Albrecht, Gamarra, Fernando, Huber, Rudolf M., Jörres, Rudolf A.   +6 more
core   +1 more source

A comprehensive analysis of interleukin-4 receptor polymorphisms and their association with atopy and IgE regulation in childhood [PDF]

, 2004
Background: The interleukin (IL) 4/IL13 pathway is involved in the regulation of IgE production associated with atopic diseases. Numerous polymorphisms have been identified in the coding region of the IL4 receptor alpha chain (IL4Ra) and previous ...
Kabesch, Michael, Stachel, Daniel, Carr, David, Schmid, Irene, Woitsch, Bernd, Weiland, Stephan K., Fritzsch, Christian, Mutius, Erika von   +7 more
core   +1 more source

Role of macrophage-mediated Toll-like receptor 4–interleukin-1R signaling in ectopic tongue pain associated with tooth pulp inflammation

Journal of Neuroinflammation, 2020
Background The existence of referred pain and ectopic paresthesia caused by tooth pulp inflammation may make definitive diagnosis difficult and cause misdiagnosis or mistreatment; thus, elucidation of that molecular mechanism is urgent.
Kohei Kanno, Kohei Shimizu, Masamichi Shinoda, Makoto Hayashi, Osamu Takeichi, Koichi Iwata   +5 more
doaj   +1 more source

IL-4 Receptor α Is an Important Modulator of IL-4 and IL-13 Receptor Binding: Implications for the Development of Therapeutic Targets [PDF]

The Journal of Immunology, 2006
Abstract IL-4 is a key cytokine associated with allergy and asthma. Induction of cell signaling by IL-4 involves interaction with its cognate receptors, a complex of IL-4Rα with either the common γ-chain or the IL-13R chain α1 (IL-13Rα1).
Andrews, Allison-Lynn, Holloway, John W., Holgate, Stephen T., Davies, Donna E.   +3 more
openaire   +3 more sources