Results 41 to 50 of about 18,323,172 (295)

Expression of interleukin-18 receptor in fibroblast-like synoviocytes [PDF]

, 2001
An excess of the proinflammatory substance IL-18 is present in joints of patients with rheumatoid arthritis (RA), and expression of IL-18 receptor (IL-18R) regulates IL-18 bioactivity in various cell types.
Hoelzer, Dieter (Prof. Dr.), Rehart, Stefan, Kalina, Uwe, Kessler, Uta, Kukoc-Zivojnov, Natasa, Kaltwasser, Joachim Peter (Prof. Dr.), Ottmann, Oliver G., Möller, Burkhard   +7 more
core   +1 more source

Regulation of IL-4 receptor signaling by STUB1 in lung inflammation. [PDF]

Am J Respir Crit Care Med, 2014
Abstract Rationale IL-4Rα, the common receptor component for IL-4 and IL-13, plays a critical role in IL-4– and IL-13–mediated signaling pathways that regulate airway inflammation and remodeling.
Wei Q, Sha Y, Bhattacharya A, Abdel Fattah E, Bonilla D, Jyothula SS, Pandit L, Khurana Hershey GK, Eissa NT.   +8 more
europepmc   +4 more sources

Protein Tyrosine Phosphatase Activity Is Required for IL-4 Induction of IL-4 Receptor α-Chain [PDF]

The Journal of Immunology, 2000
Abstract To investigate the role of protein tyrosine phosphatases in IL-4Rα-chain expression and signaling, we first established that SHP-1, but not SHP-2, coimmunoprecipitated with anti-IL-4Rα chain Abs in extracts prepared from resting lymphocytes.
H, Huang, W E, Paul
openaire   +2 more sources

Cytoplasmic tail of IL-13Ralpha2 regulates IL-4 signal transduction

, 2009
IL (interleukin)-4 and IL-13 are key cytokines in the pathogenesis of allergic inflammatory disease. IL-4 and IL-13 share many functional properties as a result of their utilization of a common receptor complex comprising IL-13Ralpha1 (IL-13 receptor ...
Donna E. Davies, Holgate, Stephen T, Isabelle Kirby, Ida Karin Nordgren, Tavassoli, Ali, Davies, Donna E, Holloway, John W, Andrews, Allison-Lynn, Stephen T. Holgate, Nordgren, Ida Karin, John W. Holloway, Kirby, Isabelle, Allison-Lynn Andrews, Ali Tavassoli   +13 more
core   +1 more source

Colony-stimulating factor-1 suppresses responses to CpG DNA and expression of toll-like receptor 9 but enhances responses to lipopolysaccharide in murine macrophages [PDF]

, 2002
During bacterial infections, the balance between resolution of infection and development of sepsis is dependent upon the macrophage response to bacterial products.
Sweet, Matthew J, Foo Y. Liew, Sester, David P, Katryn J. Stacey, Xu, Damo, David P. Sester, Rebecca C. McDonald, David A. Hume, McDonald, Rebecca C, Campbell, Carol C, Stacey, Katryn J, Hume, David A, Liew, Foo Y, Matthew J. Sweet, Carol C. Campbell, Damo Xu   +15 more
core   +1 more source

Role of interleukin-4 receptor α polymorphism in patients with asthma and its correlation with asthma severity

Monaldi Archives for Chest Disease
Asthma is a heterogeneous disease characterized by chronic airway inflammation. It is defined by the history of respiratory symptoms such as wheeze, shortness of breath, chest tightness, and cough that vary over time and intensity, together with ...
Nidhi Girdhar, Karan Sharma, Satyajit Deshpande, Siddharth Sharma, Vishal Chopra, Anil Sontakke   +5 more
doaj   +1 more source

IL-4 and IL-13 induce equivalent expression of traditional M2 markers and modulation of reactive oxygen species in human macrophages

Scientific Reports, 2023
In cardiovascular disease, pathological and protective roles are reported for the Th2 cytokines IL-4 and IL-13, respectively. We hypothesised that differential effects on macrophage function are responsible. Type I and II receptor subunit (IL-2Rγ, IL-4Rα
Tara E. Scott, Caitlin V. Lewis, Mingyu Zhu, Chao Wang, Chrishan S. Samuel, Grant R. Drummond, Barbara K. Kemp-Harper   +6 more
doaj   +1 more source

Biological Therapy of Severe Asthma with Dupilumab, a Dual Receptor Antagonist of Interleukins 4 and 13

Vaccines, 2022
Interleukin-4 (IL-4) and interleukin-13 (IL-13) are key cytokines involved in the pathophysiology of both immune-inflammatory and structural changes underlying type 2 asthma.
Corrado Pelaia, Giulia Pelaia, Claudia Crimi, Angelantonio Maglio, Giuseppe Armentaro, Cecilia Calabrese, Angela Sciacqua, Luca Gallelli, Alessandro Vatrella   +8 more
doaj   +1 more source

Localization of IL‐4 and IL‐4 receptors in the human term placenta, decidua and amniochorionic membranes

Immunology, 1997
There has been much recent interest in cytokine expression at the materno–fetal interface. Although T‐helper 2 (Th2)‐type cytokines have been described in the murine feto–placental unit, few studies have as yet been performed in human pregnancy. We have examined the production of interleukin‐4 (IL‐4) and expression of IL‐4 receptors in the human term ...
M I, de Moraes-Pinto, G S, Vince, B F, Flanagan, C A, Hart, P M, Johnson   +4 more
openaire   +3 more sources

Cortical Binding Potential of Opioid Receptors in Patients With Fibromyalgia Syndrome and Reduced Systemic Interleukin-4 Levels – A Pilot Study

Frontiers in Neuroscience, 2020
Objective: We investigated cerebral opioid receptor binding potential in patients with fibromyalgia syndrome (FMS) using positron-emission-tomography (PET) and correlated our results with patients’ systemic interleukin-4 (IL-4) gene expression.Methods ...
Nurcan Üçeyler, Hans-Georg Buchholz, Susanne Kewenig, Stephan-Johann Ament, Frank Birklein, Mathias Schreckenberger, Claudia Sommer   +6 more
doaj   +1 more source