Results 1 to 10 of about 73,798 (303)

Matrix stiffness affects endocytic uptake of MK2-inhibitor peptides. [PDF]

PLoS ONE, 2014
In this study, the role of substrate stiffness on the endocytic uptake of a cell-penetrating peptide was investigated. The cell-penetrating peptide, an inhibitor of mitogen-activated protein kinase activated protein kinase II (MK2), enters a primary ...
Jamie L Brugnano, Alyssa Panitch
doaj   +8 more sources

The C-terminal domain of Emi2 conjugated to cell-penetrating peptide activates mouse oocyte [PDF]

Frontiers in Cell and Developmental Biology
IntroductionThe cell cycle of ovulated oocytes from various animal species, including mice, arrests at the second meiotic metaphase until fertilization. The meiotic cell cycle must be initiated to initiate embryonic development.
Toru Suzuki, Toru Suzuki
doaj   +2 more sources

Curvature-Induced Membrane Remodeling by the Cell-Penetrating Peptide Pep-1 [PDF]

Membranes
The cell-penetrating peptide Pep-1 interacts with lipid membranes through combined electrostatic and hydrophobic forces, yet the structural details of its membrane remodeling activity remain unclear.
Yasith Indigahawela Gamage, Jianjun Pan
doaj   +2 more sources

Fusion Partner Facilitates Expression of Cell-Penetrating Peptide L2 in Pichia pastoris [PDF]

Antibiotics
Background: L2 is formed by combining the pheromone of Streptococcus agalactiae (S. agalactiae) and a cell-penetrating peptide (CPP) with cell-penetrating selectivity. L2 has more significant penetration and better specificity for killing S.
Xuan Li, Na Yang, Yuxin Fang, Ruoyu Mao, Ya Hao, Da Teng, Na Dong, Anshan Shan, Jianhua Wang   +8 more
doaj   +2 more sources

RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry. [PDF]

Cell
Perr J, Langen A, Almahayni K, Nestola G, Chai P, Lebedenko CG, Volk RF, Detrés D, Caldwell RM, Spiekermann M, Hemberger H, Bisaria N, Aiba T, Sánchez-Rivera FJ, Tzelepis K, Calo E, Möckl L, Zaro BW, Flynn RA.   +18 more
europepmc   +2 more sources

Cell-Penetrating Antimicrobial Peptides with Anti-Infective Activity against Intracellular Pathogens

Antibiotics, 2022
Cell-penetrating peptides (CPPs) are natural or engineered peptide sequences with the intrinsic ability to internalize into a diversity of cell types and simultaneously transport hydrophilic molecules and nanomaterials, of which the cellular uptake is ...
Gabriela Silva Cruz, Ariane Teixeira dos Santos, Erika Helena Salles de Brito, Gandhi Rádis-Baptista   +3 more
doaj   +1 more source

A manganese (II)-based coordinative dendrimer with robust efficiency in intracellular peptide delivery

Bioactive Materials, 2022
Peptides have gained increasing interests as drug candidates in modern pharmaceutical industry, however, the development of peptide drugs acting on intracellular targets is limited due to their membrane impermeability.
Lanfang Ren, Yang Gao, Yiyun Cheng
doaj   +1 more source

A cancer specific cell-penetrating peptide, BR2, for the efficient delivery of an scFv into cancer cells. [PDF]

PLoS ONE, 2013
Cell-penetrating peptides (CPPs) have proven very effective as intracellular delivery vehicles for various therapeutics. However, there are some concerns about non-specific penetration and cytotoxicity of CPPs for effective cancer treatments.
Ki Jung Lim, Bong Hyun Sung, Ju Ri Shin, Young Woong Lee, Da Jung Kim, Kyung Seok Yang, Sun Chang Kim   +6 more
doaj   +1 more source

Insights into the equilibrium structure and translocation mechanism of TP1, a spontaneous membrane-translocating peptide

Scientific Reports, 2022
Crossing the cellular membrane is one of the main barriers during drug discovery; many potential drugs are rejected for their inability to integrate into the intracell fluid.
Diego Muñoz-Gacitúa, Fanny Guzman, Boris Weiss-López   +2 more
doaj   +1 more source

Improve BBB Penetration and Cytotoxicity of Palbociclib in U87-MG Glioblastoma Cells Delivered by Dual Peptide Functionalized Nanoparticles

Pharmaceutics, 2023
Palbociclib (PBC) is an FDA-approved CDK4/6 inhibitor used for breast cancer treatment. PBC has been demonstrated its ability to suppress the proliferation of glioma cells by inducing cell cycle arrest. However, the efflux transporters on the blood-brain
Yu-Chen Lo, Wen-Jen Lin
doaj   +1 more source