Results 51 to 60 of about 44,933 (233)
Elastin-Like Polypeptide Based Hydroxyapatite Bionanocomposites [PDF]
Biomacromolecules, 2011 In nature, organic matrix macromolecules play a critical role in enhancing the mechanical properties of biomineralized composites such as bone and teeth. Designing artificial matrix analogues is promising but challenging because relatively little is known about how natural matrix components function.
Eddie, Wang +2 more
openaire +2 more sources
The liquid structure of elastin
eLife, 2017 The protein elastin imparts extensibility, elastic recoil, and resilience to tissues including arterial walls, skin, lung alveoli, and the uterus. Elastin and elastin-like peptides are hydrophobic, disordered, and undergo liquid-liquid phase separation ...
Sarah Rauscher, Régis Pomès
doaj +1 more source
Smart systems related to polypeptide sequences [PDF]
, 2016 Increasing interest for the application of polypeptide-based smart systems in the biomedical field has developed due to the advantages given by the peptidic sequence.
Franco García, María Lourdes +2 more
core +2 more sources
Elastin‐like polypeptides as models of intrinsically disordered proteins [PDF]
FEBS Letters, 2015 Elastin‐like polypeptides (ELPs) are a class of stimuli‐responsive biopolymers inspired by the intrinsically disordered domains of tropoelastin that are composed of repeats of the VPGXG pentapeptide motif, where X is a “guest residue”. They undergo a reversible, thermally triggered lower critical solution temperature (LCST) phase transition, which has ...
Roberts, Stefan +2 more
openaire +2 more sources
Emerging Role of Elastin-Like Polypeptides in Regenerative Medicine
Advances in Wound Care, 2021 Significance: Wound dressing based on naturally derived polymer provides a useful platform for treatment of skin injuries. Owing to the high mechanical strength and tunable structural and physicochemical properties of human elastin-like polypeptides (ELPs), they may be used as excellent materials for fabricating
Vijaya, Sarangthem +2 more
openaire +2 more sources
Amyloidogenesis of proteolytic fragments of human elastin [PDF]
, 2013 Some polypeptides encoded by the C-terminal region of human tropoelastin gene have been demonstrated to be amyloidogenic in vitro. The biological relevance of this finding is still under investigation given that only limited evidence concerning the ...
Baud, Stéphanie +5 more
core +3 more sources
Fusions of Elastin-Like Polypeptides to Pharmaceutical Proteins [PDF]
, 2012 Elastin-like polypeptides (ELPs) are a class of stimulus-responsive biopolymers whose physicochemical properties and biocompatibility are particularly suitable for in vivo applications, such as drug delivery and tissue engineering. The lower critical solution temperature (LCST) behavior of ELPs allows them to be utilized as soluble macromolecules below
Wafa, Hassouneh +2 more
openaire +2 more sources
Biophysical Characterization of an Elastin-Like-Polypeptide [PDF]
Biophysical Journal, 2011 Perhaps the largest impediment in cancer therapies has been the inability to effectively target systemically delivered therapeutics to cancerous cells. A recent and novel approach to this problem has been to chemically conjugate the therapeutic to an Elastin-Like-Polypeptide (ELP).
Lyons, Daniel +4 more
openaire +1 more source
Trends in the design and use of elastin-like recombinamers as biomaterials [PDF]
, 2019 Producción CientíficaElastin-like recombinamers (ELRs), which derive from one of the repetitive domains found in natural elastin, have been intensively studied in the last few years from several points of view.
Acosta Rodríguez, Sergio +3 more
core +2 more sources
Thermoresponsive poly(2-oxazoline)s, polypeptoids, and polypeptides [PDF]
, 2017 This review covers the recent advances in the emerging field of thermoresponsive polyamides or polymeric amides, i.e., poly(2-oxazoline)s, polypeptoids, and polypeptides, with a specific focus on structure-thermoresponsive property relationships, self ...
Hoogenboom, Richard, Schlaad, Helmut
core +2 more sources