BioTechniques, 2016 The protocol described here is designed as an extension of existing techniques for creating elastin-like polypeptides. It allows for the expression and purification of elastin-like polypeptide (ELP) constructs that are poorly expressed or have very low ...
Markian S. Bahniuk +2 more
doaj +1 more source
Influence of homocysteine on the physical structure and molecular mobility of elastin network in cultured arteries [PDF]
, 2009 The thermal and dielectric properties of the elastin network were investigated in arteries cultured with physiological and pathological concentrations of homocysteine, an aminoacid responsible of histological impairments in human arteries.
Chareyre, Corinne +6 more
core +2 more sources
A double safety lock tumor-specific device for suicide gene therapy in breast cancer [PDF]
, 2020 Producción CientíficaThe complexity and continuous evolution of cancer make the design of novel strategies of treatment a constant challenge in biomedicine.
Arias Vallejo, Francisco Javier +5 more
core +2 more sources
Los polímeros tipo elastina y su utilización como tags para la purificación de proteínas [PDF]
, 2011 Actualmente, una de las técnicas más ampliamente utilizadas en la purificación de proteínas recombinantes es la cromatografía de afinidad. Sin embargo, esta técnica es costosa, requiere de equipo especializado y es difícil de escalar.
Arias, F.J. +4 more
core +2 more sources
The application of elastin-like peptides in cancer, tissue engineering and ocular disease
OpenNano, 2023 Elastin-like polypeptides (ELPs) are macromolecular biopolymers composed of natural amino acids. ELPs can be prepared by genetic engineering so that their amino acid sequences and molecular weight can be precisely manipulated.
Dabo Jiang +7 more
doaj +1 more source
Conformational and thermal characterization of a synthetic peptidic fragment inspired from human tropoelastin: Signature of the amyloid fibers [PDF]
, 2014 Objectives : This work deals with the conformational and thermal characterization of a synthetic peptide (S4) released during the proteolysis of human tropoelastin by the matrix metalloproteinase-12 that was shown to form amyloid-like fibres under ...
Bochicchio, Brigida +5 more
core +4 more sources
Protein-based materials, toward a new level of structural control [PDF]
, 2001 Through billions of years of evolution nature has created and refined structural proteins for a wide variety of specific purposes. Amino acid sequences and their associated folding patterns combine to create elastic, rigid or tough materials.
Tirrell, David A., van Hest, Jan C. M.
core +1 more source
Evaluation of Elastin-Like Polypeptides for Tumor Targeted Delivery of Doxorubicin to Glioblastoma
Molecules, 2019 To increase treatment efficiency for glioblastoma, we have developed a system to selectively deliver chemotherapeutic doxorubicin (Dox) to Glioblastoma (GBM) tumors.
Sonja Dragojevic +2 more
doaj +1 more source
Transient dynamic mechanical properties of resilin-based elastomeric hydrogels [PDF]
, 2014 The outstanding high-frequency properties of emerging resilin-like polypeptides (RLPs) have motivated their development for vocal fold tissue regeneration and other applications.
Kristi L. Kiick, Linqing Li
core +1 more source
Growth factor purification and delivery systems (PADS) for therapeutic angiogenesis [PDF]
, 2015 BACKGROUND: Therapeutic angiogenesis with vascular endothelial growth factor (VEGF), delivered either via recombinant protein infusion or via gene therapy, has shown promise in preclinical models of various diseases including myocardial infarction ...
Eddie Perkins +5 more
core +1 more source