Results 81 to 90 of about 6,079 (163)

Self‐Immolative Gels: Programmable Degradation Using Self‐Immolative Linkers and Polymers

Chemistry – A European Journal, Volume 32, Issue 23, 16 June 2026.
Self‐immolative linkers and polymers undergo bond‐cleaving reaction cascades in response to specific stimuli. Their incorporation into gels can be harnessed to release cargo, induce property changes, or trigger degradation in a highly controlled manner. These functions can be employed in applications such as sensing and drug delivery.
Chuanfeng Li, Elizabeth R. Gillies
wiley   +1 more source

Racemisation of Amino Acids: From Synthetic Challenge to Biological Significance

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Racemisation, once considered an undesirable synthetic side reaction, also occurs naturally in amino acids and influences biological processes. Evidence links stereochemical conversion to ageing, protein turnover, and cellular development. This review examines mechanisms, control strategies in synthesis, applications and implications in physiology ...
Othman Al Musaimi
wiley   +1 more source

Rational Design and One-Step Immobilization of Chitosanase for Specific and Recyclable Chitobiose Production

Foods
Chitosan oligosaccharides (COSs) with defined degrees of polymerization (DP) exhibit distinct bioactivities with promising applications in food, pharmaceutical, and agricultural industries. However, the specific and sustainable production of COSs remains
Dandan Tang, Jie Zhang, Na Li, Rui Long, Xinyu Wang, Xiaowen Wang, Wei Liu   +6 more
doaj   +1 more source

A stretchable, electroconductive tissue adhesive for the treatment of neural injury

Bioengineering & Translational Medicine
Successful nerve repair using bioadhesive hydrogels demands minimizing tissue–material interfacial mechanical mismatch to reduce immune responses and scar tissue formation.
Jharana Dhal, Mahsa Ghovvati, Avijit Baidya, Ronak Afshari, Curtis L. Cetrulo Jr, Reza Abdi, Nasim Annabi   +6 more
doaj   +1 more source

Thermally-Responsive Loading and Release of Elastin-Like Polypeptides from Contact Lenses

Pharmaceutics, 2019
Contact lenses are widely prescribed for vision correction, and as such they are an attractive platform for drug delivery to the anterior segment of the eye.
Wan Wang, Changrim Lee, Martha Pastuszka, Gordon W. Laurie, J. Andrew MacKay   +4 more
doaj   +1 more source

Material engineering and application of hybrid biomimetic-de novo designed elastin-like polypeptides

Communications Materials
The global concern over environmental consequences of petrochemical-derived plastics underscores the urgent need for sustainable and biodegradable polymers.
Zhuoran Geng, Timo Laakko, Ari Hokkanen, Caj Södergård, Ilari Maasilta, Pezhman Mohammadi   +5 more
doaj   +1 more source

Molecular Size Modulates Pharmacokinetics, Biodistribution, and Renal Deposition of the Drug Delivery Biopolymer Elastin-like Polypeptide

Scientific Reports, 2018
Elastin-like polypeptides (ELP) are engineered proteins that consist of repetitions of a five amino acid motif, and their composition is easily modified to adjust their physical properties and attach therapeutics.
Marija Kuna, Fakhri Mahdi, Alejandro R. Chade, Gene L. Bidwell   +3 more
doaj   +1 more source

Injectable thixotropic hydrogel composed of elastin-like polypeptide and oxidized dextran for anastomotic support

NPG Asia Materials
Anastomotic leakage remains a serious complication in gastrointestinal surgery, with unsatisfactory improvement in incidence over recent decades. Conventional sealants, such as fibrin glue, require intraoperative mixing and offer limited ease of handling.
Yuki Aoyama, Yuta Nakano, Takahiro Shinozuka, Kotaro Aoki, Kazumasa Suzuki, Chikara Ohtsuki, Mitsuro Kanda, Ayae Sugawara-Narutaki   +7 more
doaj   +1 more source

Intracellular Delivery of a p21-Derived Cell Cycle Inhibitory Peptide Using Elastin-like Polypeptides Suppresses Glioblastoma Cell Proliferation

Molecules
Glioblastoma, with a 5-year survival rate of just under 7.0%, is the most common form of brain cancer in adults. In this study, we evaluated the antiproliferative activity of the biopolymer p21-ELP1-Bac, a p21-derived peptide delivered via an elastin ...
Tiffany Quinn, Yumnaa Shaheen, Drazen Raucher   +2 more
doaj   +1 more source

How conformational transition depends on hydrophobicity of elastin-like polypeptides

The European Physical Journal E, 2010
The three-dimensional structures of elastin-like polypeptides Val1-Pro2-Gly3-Xaa4-Gly5 were investigated by using the multicanonical Monte Carlo (MC) simulation procedure. By substituting different amino acids in the fourth position of the sequence, the thermodynamical variables are calculated in vacuo and in solvent to determine the hydrophobicity ...
Arkin, H., Bilsel, M.
openaire   +3 more sources