Results 91 to 100 of about 4,594,965 (203)

Design and evaluation of a bifunctional fusion polypeptide for targeted delivery of tigecycline against drug-resistant Klebsiella pneumoniae

Journal of Nanobiotechnology
The overuse of antibiotics and the continuous evolution of drug-resistant bacteria present substantial obstacles to the clinical treatment of Carbapenem-resistant Klebsiella pneumoniae (CRKP) infections.
Meiling Zhou, Yuming Yao, Shuo Ma, Yaya Chen, GuliNazhaer Abudushalamu, Dawen Chen, Xiao Li, Yan Tao, Yue Hou, Xun Gao, Fengfeng Zhao, Chen Zhang, Hua Shao, Guoqiu Wu   +13 more
doaj   +1 more source

Technologies for engineering repetitive DNA

Quantitative Biology, Volume 14, Issue 3, September 2026.
Abstract Repetitive DNA, a fundamental architectural element of genomes, is widespread across organisms and comprises about 54% of the human genome. With advances in long‐read sequencing and bioinformatics approaches, highly repetitive sequences can now be characterized in depth.
Shuting Ma, Yali Cui, Yi Wu
wiley   +1 more source

Design and production of a chimeric resilin-, elastin-, and collagen-like engineered polypeptide.

, 2011
Protein-inspired biomaterials have gained great interest as an alternative to synthetic polymers, in particular, for their potential use as biomedical devices.
Marletta, Giovanni, BRACALELLO, Angelo, A. Pepe, Valentina Santopietro, Vassalli, Massimo, B. Bochicchio, Giovanni Marletta, Rosanna Del Gaudio, A. Bracalello, R. D. Gaudio, G. Marletta, V. Santopietro, PEPE, Antonietta, Brigida Bochicchio, Massimo Vassalli, M. Vassalli, BOCHICCHIO, Brigida, Angelo Bracalello, Antonietta Pepe, SANTOPIETRO, VALENTINA, DEL GAUDIO, ROSANNA   +20 more
core   +1 more source

Neurotrophic Signaling, Sleep Physiology, and Retinal Neuroprotection: Integrative Mechanisms and Therapeutic Implications for Glaucoma

Sensory Neuroscience, Volume 2, Issue 3, September 2026.
Glaucoma is increasingly understood as a neurodegenerative disorder shaped by sleep and circadian physiology, not intraocular pressure alone. Sleep loss and obstructive sleep apnea suppress BDNF–TrkB neurotrophic signaling, impair sleep‐dependent glymphatic clearance, and trigger microglial neuroinflammation and vascular insult at the optic nerve head,
Karyme M. Alemán‐Villa, Emiliano Terán, Javier A. Magaña‐Gómez, Loranda Calderón‐Zamora, Beatriz K. De la Herrán‐Arita, Alberto K. De la Herrán‐Arita   +5 more
wiley   +1 more source

Topology‐Encoded Charge Polarity Governs Multiphase Organization in Intrinsically Disordered Protein Polymer Condensates

Small, Volume 22, Issue 52, 16 September 2026.
Electrostatic topology is shown to program phase separation and internal organization in thermoresponsive intrinsically disordered protein polymer (IDPP) condensates. By comparing oppositely charged IDPPs with a covalent diblock, chain connectivity is revealed to control charge compensation, dense‐phase micropolarity, miscibility, and apparent acid ...
Julio Fernández‐Fernández, Vicente Domínguez‐Arca, Raúl Escribano, Sheila Lorenzo, Sergio Ferrero, Sergio Acosta, José Carlos Rodríguez‐Cabello   +6 more
wiley   +1 more source

Cross-Linked Elastin-like Polypeptide Membranes as a Model for Medial Arterial Calcification

, 2019
Calcium phosphate minerals deposit on the elastin-rich medial layers of arteries in the majority of seniors, diabetic, and chronic kidney disease patients, causing severe cardiovascular complications.
Lisa D. Muiznieks (306213), Antonio Nanci (2184372), Dainelys Guadarrama Bello (6865652), Ophélie Gourgas (6865649), Marta Cerruti (1385694), Simon Sharpe (1935058)   +5 more
core   +1 more source

Rational Design and One-Step Immobilization of Chitosanase for Specific and Recyclable Chitobiose Production

Foods
Chitosan oligosaccharides (COSs) with defined degrees of polymerization (DP) exhibit distinct bioactivities with promising applications in food, pharmaceutical, and agricultural industries. However, the specific and sustainable production of COSs remains
Dandan Tang, Jie Zhang, Na Li, Rui Long, Xinyu Wang, Xiaowen Wang, Wei Liu   +6 more
doaj   +1 more source

Modeling and Experiment Reveal Structure and Nanomechanics across the Inverse Temperature Transition in B. mori Silk-Elastin-like Protein Polymers

, 2017
Silk and elastin are exemplary protein materials that exhibit exceptional material properties. Silk is uniquely strong, surpassing engineering materials such as Kevlar and steel, while elastin has exquisite flexibility and can reversibly fold into a more
Anna Tarakanova (3931679), Zhao Qin (258824), Wenwen Huang (327269), Markus J. Buehler (184481), David L. Kaplan (131325)   +4 more
core   +1 more source

Cylindrical Polymer Brushes with Elastin-Like Polypeptide Side Chains

, 2016
Monodisperse high molar mass elastin-like polypeptide macromonomers comprising 20 pentasequences (M = 8332 g/mol) were radically polymerized to high degrees of polymerization Pw = 590.
Jonathan R. McDaniel (1943383), Désirée Weller (1887205), Ashutosh Chilkoti (1266378), Karl Fischer (1620511), Manfred Schmidt (57321)   +4 more
core   +1 more source

A stretchable, electroconductive tissue adhesive for the treatment of neural injury

Bioengineering & Translational Medicine
Successful nerve repair using bioadhesive hydrogels demands minimizing tissue–material interfacial mechanical mismatch to reduce immune responses and scar tissue formation.
Jharana Dhal, Mahsa Ghovvati, Avijit Baidya, Ronak Afshari, Curtis L. Cetrulo Jr, Reza Abdi, Nasim Annabi   +6 more
doaj   +1 more source