Results 111 to 120 of about 4,594,965 (203)

Molecular Size Modulates Pharmacokinetics, Biodistribution, and Renal Deposition of the Drug Delivery Biopolymer Elastin-like Polypeptide

Scientific Reports, 2018
Elastin-like polypeptides (ELP) are engineered proteins that consist of repetitions of a five amino acid motif, and their composition is easily modified to adjust their physical properties and attach therapeutics.
Marija Kuna, Fakhri Mahdi, Alejandro R. Chade, Gene L. Bidwell   +3 more
doaj   +1 more source

Fusion of cell-penetrating peptides to thermally responsive biopolymer improves tumor accumulation of p21 peptide in a mouse model of pancreatic cancer

Drug Design, Development and Therapy, 2014
Leslie R Walker,1 Jung Su Ryu,1 Eddie Perkins,2 Lacey R McNally,3 Drazen Raucher1 1Department of Biochemistry, 2Department of Neurosurgery, University of Mississippi Medical Center, Jackson, MS, USA; 3Division of Hematology and Oncology, University of ...
Walker LR, Ryu JS, Perkins E, McNally LR, Raucher D   +4 more
doaj  

RGD-containing elastin like polypeptide improves islet transplantation outcomes in diabetic mice

, 2019
Successful islet transplantation critically depends on the isolation of healthy islets. However, the islet isolation procedure itself contributes to islet death due to the destruction of intra- and peri-islet extracellular matrices (ECMs) during ...
Kim, Jung-Hee, Choi, Eun-Sook, Jeon, Won Bae, Lee, Kyeong-Min, Choi, Seong-Kyoon, Kim, Eunjoo   +5 more
core   +1 more source

Engineering Elastin-Like Polypeptide-Poly(ethylene glycol) Multiblock Physical Networks

, 2018
Hybrids of protein biopolymers and synthetic polymers are a promising new class of soft materials, as the advantages of each component can be complementary.
Araújo, Andreia Isabel Silva, Andreia Araújo, Bradley D. Olsen, Ana Vera Machado, Machado, A. V., Olsen, Bradley D.   +5 more
core   +1 more source

Engineered Elastin‐Like Polypeptides: Intelligent Self‐Assembling Platforms for Biomedical Application

Small Structures
Elastin‐like polypeptides (ELPs), genetically programmable biomaterials derived from natural tropoelastin, exhibit unique reversible self‐assembly and aggregation behaviors driven by sequence‐encoded phase transitions.
Yang Yuan, Chen Zeng, Zichun Chen, Zhuoga Ciren, Qinran Yu, Chuanbo Wang, Hui Mao, Gang Li, Weizhi Chen, Xiqun Jiang   +9 more
doaj   +1 more source

Biological behavior of endothelial cells on Human Elastin-like Polypeptide-based biomaterials

, 2010
Bioinspired artificial proteins modelled on tropoelastin represent an attractive tool for many biotechnological and biomedical applications. In this work, a recombinant Human Elastin-like Polypeptide (HELP) comprising the most regularly repeated ...
BANDIERA, Antonella, Parnigotto, P. P., Conconi M. T., Bozzini S., Urbani L.   +4 more
core  

Robust Photocontrol of Elastin-like Polypeptide Phase Transition with a Genetically Encoded Arylazopyrazole. [PDF]

ACS Synth Biol, 2023
Strugach DS, Hadar D, Amiram M.
europepmc   +1 more source

In vitro Myogenesis induced by Human Recombinant Elastin-Like Proteins

, 2015
Mammalian adult skeletal muscle has a limited ability to regenerate after injury, usage or trauma. A promising strategy for successful regenerative technology is the engineering of bio interfaces that mimic the characteristics of the extracellular matrix.
PASSAMONTI, SABINA, ULLOA SEVERINO, LUISA, Bandiera, A., Severino, L.U., BORELLI, VIOLETTA, SCAINI, DENIS, Scaini, D., D'ANDREA, PAOLA, BANDIERA, Antonella, Borelli, V., Passamonti, S., Lorenzon, P., LORENZON, Paola, Severino, L. U., D'Andrea, P.   +14 more
core   +1 more source

Elastin-like polypeptide delivery of anti-inflammatory peptides to the brain following ischemic stroke. [PDF]

FASEB J, 2023
Howell JA, Gaouette N, Lopez M, Burke SP, Perkins E, Bidwell GL.   +5 more
europepmc   +1 more source

Characterization of a Chimeric Resilin-Elastin Structural Protein Dedicated to 3D Bioprinting as a Bioink Component

Nanomaterials
In this study we propose to use for bioprinting a bioink enriched with a recombinant RE15mR protein with a molecular weight of 26 kDa, containing functional sequences derived from resilin and elastin.
Violetta Cecuda-Adamczewska, Agnieszka Romanik-Chruścielewska, Katarzyna Kosowska, Natalia Łukasiewicz, Iwona Sokołowska, Paulina Korycka, Katarzyna Florys-Jankowska, Agnieszka Zakrzewska, Michał Wszoła, Marta Klak   +9 more
doaj   +1 more source