Results 131 to 140 of about 6,079 (163)
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Cytokine conjugates to elastin-like polypeptides
Advanced Drug Delivery Reviews, 2022Cytokines are a group of pleiotropic proteins which are crucial for various biological processes and useful as therapeutics. However, they usually suffer from the poor stability, extreme short circulation half-life, difficulty in high-yield and large-scale production and side effects, which greatly restricts their applications.
Like, Gong +3 more
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Recombination and Purification of Elastin-Like Polypeptides
2021Elastin, as an extracellular matrix protein, has inherent advantages for biomedical applications. For example, it is highly extensible and biocompatible, biodegradable, and has no immunogenicity. However, directly extracting elastin from biological tissues remains challenging because they usually coexist with other proteins such as collagen. Therefore,
Chenxi, Zhao +4 more
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Genetically Encoded Elastin‐Like Polypeptides for Drug Delivery
Advanced Healthcare Materials, 2021AbstractElastin‐like polypeptides (ELPs) are thermally responsive biopolymers that consist of a repeated amino acid motif derived from human tropoelastin. These peptides exhibit temperature‐dependent phase behavior that can be harnessed to produce stimuli‐responsive biomaterials, such as nanoparticles or injectable drug delivery depots.
Irene C. Jenkins +2 more
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Spectroscopic studies on elastin-like synthetic polypeptides
International Journal of Biological Macromolecules, 1990Spectroscopic studies on synthetic polypeptides containing the unit-X-G-G (X=V or L) are reported. The sequences, constituting either fragments or model of elastin, were shown to adopt type II beta-turns together with an ensemble of unordered conformations.
M. A. CASTIGLIONE MORELLI +3 more
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Self-assembled elastin-like polypeptide particles
Acta Biomaterialia, 2008In this work, the self-assembly of a recombinant elastin-based block copolymer containing both hydrophobic and cross-linking domains from the human elastin protein was investigated. The particle formation and dynamic behavior were characterized using inverted microscopy and dynamic light scattering.
Jill L, Osborne +2 more
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Epitope tagging for tracking elastin-like polypeptides
Biomaterials, 2006Elastin-like polypeptides (ELPs) are a class of biocompatible, non-immunogenic and crosslinkable biomaterials that offer promise for use as an injectable scaffold for cartilage repair. In this study, an oligohistidine (His(6)) epitope tag was incorporated at the N-terminus of an ELP using recombinant DNA techniques to permit tracking without ...
Shin R, Ong +5 more
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Catechol-Functionalized Elastin-like Polypeptides as Tissue Adhesives
Biomacromolecules, 2020Adhesives can potentially be used to achieve fast and efficient wound closure; however, current products show poor bonding on wet surfaces, undergo swelling, and lack adequate biocompatibility. We designed a hydrogel adhesive with recombinant elastin-like polypeptides (ELPs), which are flexible proteins that can be customized for biomedical needs.
Malav S. Desai +5 more
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Elastin‐like polypeptides: A strategic fusion partner for biologics
Biotechnology and Bioengineering, 2016ABSTRACTElastin‐like peptides (ELPs) are derivatives of tropoelastin with a unique property that allows them to stay soluble below a certain critical temperature but reversibly form aggregates above that temperature. Since they are derived from tropoelastin, ELPs are biocompatible, non‐toxic, and non‐immunogenic. The unique properties of ELPs have made
Agnes, Yeboah +4 more
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Graphene-Based Materials Functionalized with Elastin-like Polypeptides
Langmuir, 2014Graphene-based materials commonly require functionalization for biological applications in order to control their physical/colloidal properties and to introduce additional capabilities, such as stimuli-responsiveness and affinity to specific biomolecules.
Eddie, Wang +3 more
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Molecular Description of the LCST Behavior of an Elastin-Like Polypeptide
Biomacromolecules, 2014Elastin-like polypeptides (ELPs) with the repeat sequence of VPGVG are widely used as a model system for investigation of lower critical solution temperature (LCST) transition behavior. In this paper, the effect of temperature on the structure, dynamics and association of (VPGVG)18 in aqueous solution is investigated using atomistic molecular dynamics ...
Nan K, Li +4 more
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