Results 121 to 130 of about 29,969 (357)

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Comprehend to Comprehension: Teaching Nominalization to Secondary ELD Teachers

open access: yes, 2011
Research Question. What happens when ELD teachers learn about nominalization as it is used in academic texts? Subquestions. (1) What understandings do ELD teachers currently have of nominalization, and how did they acquire the knowledge they have?
Cameron, Janelle Shara
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

Utopias e micro-utopias: abordagens e práticas criativas para a arquitetura no campo expandido [PDF]

open access: yes, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Urbanismo, História e Arquitetura da Cidade, Florianópolis, 2014.Historicamente, o termo utopia se refere a uma forma de pensar que perpassa
Silva, Diego Fagundes da
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Lung eosinophils are highly activated during ELD.

open access: yes
Geometric mean of the fluorescence intensity (gMFI) of (A) CD11b, (B) Siglec-F, (C) CD86 and (D) ST2/IL-33R of lung eosinophils isolated from wild-type ELD mice, mice solely challenged with MF (MF) or naïve animals ten days after MF challenge.
Joséphine Gal (14000010)   +11 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

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