Results 141 to 150 of about 2,744,109 (362)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Blood pressure control in Türkiye: A primary healthcare pilot study

Preventive Medicine Reports
Hypertension is present in almost a third of Türkiye’s adult population. The Ministry of Health of the Republic of Türkiye in conjunction with the World Health Organization, rolled out a pilot primary health care model from February 2019 to 2020 to ...
Banu Ekinci, Saion Chatterjee, Ilayda Ucuncu, Zubeyde Ozkan Altunay, Tufan Nayir, Secil Sis, Esin Yilmaz Aslan, Nevin Cobanoglu, Gulay Sarıoglu, Fatma Tamkoc Gurbuzturk, Sila Toker, Secil Ozkan, Toker Erguder   +12 more
doaj   +1 more source

The Elderly

Journal of Atherosclerosis and Thrombosis, 2014
Tamio, Teramoto, Jun, Sasaki, Shun, Ishibashi, Sadatoshi, Birou, Hiroyuki, Daida, Seitaro, Dohi, Genshi, Egusa, Takafumi, Hiro, Kazuhiko, Hirobe, Mami, Iida, Shinji, Kihara, Makoto, Kinoshita, Chizuko, Maruyama, Takao, Ohta, Tomonori, Okamura, Shizuya, Yamashita, Masayuki, Yokode, Koutaro, Yokote   +17 more
openaire   +3 more sources

A Good Life in Old Age: Accommodating Elderly Patients\u27 Values and Motivations in the Thai Healthcare System [PDF]

, 2016
People over age sixty-five are the fastest growing segment of the population in most developed and developing nations and their healthcare problems are placing strains on healthcare systems.
Marinucci, Jennie Lynn
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Does low body weight mediate the relationship between tooth loss and cognitive impairment? A longitudinal cohort study of an older Chinese population

BMC Geriatrics
Objective Our study aimed to investigate the relationship between the number of teeth remaining and cognitive impairment among Chinese older adults, and to explore the role of low body weight in this association. Methods Data were drawn from 2011 to 2014
Pan Ke, Zuxun Lu, Wenqing Ni, Yan Zhang, Hongmin Zhang, Yijin Zheng, Xueli Yuan, Jian Xu, Xiaoxv Yin, Zhiguang Zhao   +9 more
doaj   +1 more source

The Participants Satisfaction of Supporting Projects for Social Participation of the Elderly: about Business Start-up or Employment Policies

, 2015
김경아
openalex   +1 more source

The Relationship Between Spirituality and Depression Among the Elderly in Indonesia [PDF]

, 2017
Background: Studies have shown that there is an association between spirituality and better physical and mental health. Depression has one of the highest prevalence amongst the mental health illnesses in the elderly, and it can lead to poor physical ...
Mahwati, Y. (Yeni)
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source