Results 121 to 130 of about 2,744,109 (362)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The impact of probiotics on glycemic control during the first 3 months after sleeve gastrectomy: a prospective placebo‑controlled study

Videosurgery and Other Miniinvasive Techniques
Introduction: Sleeve gastrectomy (SG) is a safe metabolic and bariatric surgery but it often leads to postoperative gastrointestinal issues, such as constipation and bloating. The use of probiotics after SG seems to alleviate these symptoms.
Natalia Mazek, Julia Młyńska, Ewelina Sosnowska-Turek, Paweł Lech, Natalia Dowgiałło-Gornowicz   +4 more
doaj   +1 more source

Vaccine coverage and factors associated with influenza vaccination in the elderly in the city of São Paulo, Brazil: SABE Study 2015

, 2021
Ana Paula Sayuri Sato, Fabíola Bof de Andrade, Yeda A. O. Duarte, José Leopoldo Ferreira Antunes   +3 more
openalex   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A Novel Theoretical Hypothesis on Comorbidity in the Elderly—The Disease of Sympathetic Overdrive (DSO)

Aging Medicine
The coexistence of multimorbidity and geriatric syndromes is a big character and role target to manage for the clinic works in older age, but related theories still require innovation and exploration.
Li Jie, Kong Jian, Yu Boxin, Li Hongyang
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Frailty is Associated with Low Self‐Esteem in Elderly Adults [PDF]

, 2014
Paulette Guerrero‐Escobedo, Óscar Tamez-Rivera, Hélène Amieva, José Alberto Ávila‐Funes   +3 more
openalex   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Free wall rupture in the elderly: deleterious effect of fibrinolytic therapy on the ageing heartThe opinions expressed in this article are not necessarily those of the Editors of the European Heart Journal or of the European Society of Cardiology. [PDF]

, 2005
Ellen C. Keeley, James A. de Lemos
openalex   +1 more source

Case Report: Nocardia amamiensis Infection Leading to Worsening of Chronic Obstructive Pulmonary Disease Symptoms in an Elderly Man [PDF]

, 2023
Ahalya Kanakan, Amit Kumar, Upinder Kaur, Prity Narwade, Zinnu Rain, Nidhi Yadav, Ishan Kumar, Deepak Kumar, Sankha Shubhra Chakrabarti   +8 more
openalex   +1 more source