Results 111 to 120 of about 1,374,958 (308)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Perioperative care in the elderly
, 2017 Ageing alters physiology, pharmacology, and is associated with increased comorbidities. Reduced cardiovascular and respiratory adaptability, as well as metabolic and pharmacokinetic differences necessitates dose reduction of anaesthetic and analgesic ...
Hollós, Balázs
core
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
BMC SurgeryObjective Failure to understand long-term quality of life and functional outcomes hinders effective decision making and prognostication. Therefore, the study aims to predict and analyse the unfavorable outcomes (FOs) in elderly patients undergoing lumbar
Peng Cui +6 more
doaj +1 more source
Good Death Study of Elderly Patients with Terminal Cancer in Taiwan
, 2011 Over half of all terminal cancer patients in Taiwan are 65 or older, thus demonstrating the importance of terminal care for elderly people. This study investigates the good death status of elderly patients with terminal cancer, comparing the differences ...
CHENG, SHAO-YI;HU, WEN-YU;LIU, WEN-JING;YAO, CHIEN-AN;CHEN, CHING-YU;CHIU, TAI-YUAN +1 more
core +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
The Elderly Population in Vietnam during Economic Transformation: An Overview [PDF]
Many studies have suggested that, under the context of high economic growth and strong flows of laborers from rural to urban areas, living arrangements of the elderly people, particularly elderly women, and familial relations will be more vulnerable to a
Pfau, Wade Donald, Giang, Thanh Long
core