Results 41 to 50 of about 1,029,485 (322)

Vaccines for the elderly [PDF]

Clinical Microbiology and Infection, 2012
Vaccination is the most efficient strategy to prevent infectious disease. The increased vulnerability to infection of the elderly makes them a particularly important target population for vaccination. However, most vaccines are less immunogenic and efficient in the elderly because of age-related changes in the immune system.
Beatrix Grubeck-Loebenstein, Birgit Weinberger   +1 more
openaire   +3 more sources

Raising enthusiasm for the medical care of elderly patients: a concept mapping study to find elements for an elderly friendly medical curriculum

BMC Medical Education, 2018
Background To deliver high quality of care for the growing population of older patients more geriatricians are needed. However, the interest of medical students for a career in geriatrics is lagging behind due to a lack of exposure, the nature of the ...
Ariadne A. Meiboom, Henk de Vries, Fedde Scheele, Cees M. P. M. Hertogh   +3 more
doaj   +1 more source

Senior Programmers: Characteristics of Elderly Users from Stack Overflow [PDF]

, 2017
In this paper we presents results of research about elderly users of Stack Overflow (Question and Answer portal for programmers). They have different roles, different main activities and different habits. They are an important part of the community, as they tend to have higher reputation and they like to share their knowledge.
arxiv   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Recommendations for clinical research in children presenting to primary care out-of-hours services: a randomised controlled trial with parallel cohort study

BJGP Open, 2021
Background: Research in primary care is essential, but recruiting children in this setting can be complex and may cause selection bias. Challenges surrounding informed consent, particularly in an acute clinical setting, can undermine feasibility. The off-
Anouk AH Weghorst, Gea A Holtman, Pien I Wolters, Heleen A Russchen, Freek Fickweiler, Henkjan J Verkade, Johan Post, Karin M Vermeulen, Boudewijn J Kollen, Irma J Bonvanie, Marjolein Y Berger   +10 more
doaj   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

VOTE400(Voide Of The Elderly 400 Hours): A Speech Dataset to Study Voice Interface for Elderly-Care [PDF]

arXiv, 2021
This paper introduces a large-scale Korean speech dataset, called VOTE400, that can be used for analyzing and recognizing voices of the elderly people. The dataset includes about 300 hours of continuous dialog speech and 100 hours of read speech, both recorded by the elderly people aged 65 years or over.
arxiv  

Contrastive study on the single-file pedestrian movement of the elderly and other age groups [PDF]

Xiangxia Ren et al J. Stat. Mech. (2019) 093402, 2019
The worldwide population is aging and countries are facing ongoing challenges in improving the safety of elderly pedestrians. In this work, single-file movement of the elderly are experimentally compared with that of different age groups. The findings indicates that the age is not the only factor influencing the pedestrian dynamics but the ...
arxiv   +1 more source

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

Community screening for dementia among older adults in China: a machine learning-based strategy

BMC Public Health
Background Dementia is a leading cause of disability in people older than 65 years worldwide. However, diagnosing dementia in its earliest symptomatic stages remains challenging.
Yan Zhang, Jian Xu, Chi Zhang, Xu Zhang, Xueli Yuan, Wenqing Ni, Hongmin Zhang, Yijin Zheng, Zhiguang Zhao   +8 more
doaj   +1 more source