Results 41 to 50 of about 1,056,966 (297)

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Hypertension in the Elderly [PDF]

International Journal of Hypertension, 2012
Background. The incidence of hypertension in the Western countries is continuously increasing in the elderly population and remains the leading cause of cardiovascular and morbidity.Methods. we analysed some significant clinical trials in order to present the relevant findings on those hypertensive population.Results.
Blas Gil-Extremera, Pedro Cía-Gómez
openaire   +3 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Community screening for dementia among older adults in China: a machine learning-based strategy

BMC Public Health
Background Dementia is a leading cause of disability in people older than 65 years worldwide. However, diagnosing dementia in its earliest symptomatic stages remains challenging.
Yan Zhang, Jian Xu, Chi Zhang, Xu Zhang, Xueli Yuan, Wenqing Ni, Hongmin Zhang, Yijin Zheng, Zhiguang Zhao   +8 more
doaj   +1 more source

Recommendations for clinical research in children presenting to primary care out-of-hours services: a randomised controlled trial with parallel cohort study

BJGP Open, 2021
Background: Research in primary care is essential, but recruiting children in this setting can be complex and may cause selection bias. Challenges surrounding informed consent, particularly in an acute clinical setting, can undermine feasibility. The off-
Anouk AH Weghorst, Gea A Holtman, Pien I Wolters, Heleen A Russchen, Freek Fickweiler, Henkjan J Verkade, Johan Post, Karin M Vermeulen, Boudewijn J Kollen, Irma J Bonvanie, Marjolein Y Berger   +10 more
doaj   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Family physicians’ preferences for education to support family caregivers: a sequential mixed methods study

BMC Primary Care
Background One in four Canadians is a family caregiver. Family caregivers (carers, care-partners) are relatives or chosen family, friends, or neighbors who provide 75 to 90% of the care for people with physical or mental illness, disabilities, or frailty
Jasneet Parmar, Sara Hafeez, Tanya L’Heureux, Lesley Charles, Josephine Tite, Peter George J. Tian, Sharon Anderson   +6 more
doaj   +1 more source

Referral rates for children with acute gastroenteritis: a retrospective cohort study

BJGP Open, 2020
Background: Hospital admission rates are increasing for children with acute gastroenteritis. However, it is unknown whether this increase is accompanied by an increase in referral rates from GPs due to increased workloads in primary care out-of-hours ...
Pien Ingrid Wolters, Gea Holtman, Freek Fickweiler, Irma Bonvanie, Anouk Weghorst, Johan Post, Boudewijn Kollen, Marjolein Berger   +7 more
doaj   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Stroke in the Setting of Giant Cell Arteritis: A Case Report

Case Reports in Medicine, 2010
We describe an unusual complication of a common disease: stroke presenting in a man recently diagnosed with polymyalgia rheumatica. Initial inflammatory markers were misleading. We discuss pitfalls in diagnosis, and approach to management.
S. McDermott, N. Casey, D. J. Robinson, K. M. Tan   +3 more
doaj   +1 more source