Results 71 to 80 of about 3,202,647 (392)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Stroke in the Setting of Giant Cell Arteritis: A Case Report

Case Reports in Medicine, 2010
We describe an unusual complication of a common disease: stroke presenting in a man recently diagnosed with polymyalgia rheumatica. Initial inflammatory markers were misleading. We discuss pitfalls in diagnosis, and approach to management.
S. McDermott, N. Casey, D. J. Robinson, K. M. Tan   +3 more
doaj   +1 more source

“We live as good a life as we can, in the situation we’re in” – the significance of the home as perceived by persons with dementia

BMC Geriatrics, 2019
Background The coming years will see more persons with dementia living longer at home. However, “the home” is a complex concept with a multitude of meanings, varying among individuals and raising ethical and practical dilemmas in the support provided for
Stein Erik Fæø, Bettina S. Husebo, Frøydis Kristine Bruvik, Oscar Tranvåg   +3 more
doaj   +1 more source

Social Security Reform: Possible Effects on the Elderly Poor and Mitigation Options [PDF]

, 2008
[Excerpt] Social Security has significantly reduced elderly poverty. The elderly poverty rate has fallen from 35% in 1959 to an all-time low of 9% in 2006, in large part because of Social Security.
Romig, Kathleen
core   +1 more source

Exergame design for elderly users: the case study of SilverBalance [PDF]

, 2010
In this paper, we discuss chances and challenges of game design for an elderly audience with a focus on the development of safe and usable exertion games for frail senior citizens.
Gerling, Kathrin, Masuch, Maic, Schild, Jonas   +2 more
core   +1 more source

Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly

New England Journal of Medicine, 2018
BACKGROUND Aspirin is a well‐established therapy for the secondary prevention of cardiovascular events. However, its role in the primary prevention of cardiovascular disease is unclear, especially in older persons, who have an increased risk.
J. McNeil, R. Wolfe, R. Woods, A. Tonkin, G. Donnan, Mark R. Nelson, C. Reid, J. Lockery, B. Kirpach, E. Storey, R. Shah, J. Williamson, K. Margolis, M. Ernst, W. Abhayaratna, N. Stocks, S. Fitzgerald, S. Orchard, R. Trevaks, L. Beilin, C. Johnston, J. Ryan, B. Radziszewska, M. Jelinek, M. Malik, C. Eaton, D. Brauer, G. Cloud, E. Wood, S. Mahady, S. Satterfield, R. Grimm, A. Murray   +32 more
semanticscholar   +1 more source

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

A rightward shift in the visuospatial attention vector with healthy aging [PDF]

, 2014
The study of lateralised visuospatial attention bias in non-clinical samples has revealed a systematic group-level leftward bias (pseudoneglect), possibly as a consequence of right hemisphere dominance for visuospatial attention. Pseudoneglect appears to
Anderson, Anderson, Angel, Ashley Grant, Barrett, Bellgrove, Benwell, Benwell, Benwell, Beste, Binetti, Bisiach, Bowers, Brooks, Brown, Bultitude, Buysse, Bäckman, Cabeza, Cabeza, Cai, Cavézian, Chen, Chokron, Christopher S. Y. Benwell, Collins, Corbetta, Corbetta, De Sanctis, Dodds, Dolcos, Doricchi, Driver, Duecker, Dufour, Failla, Fierro, Fimm, Fink, Fink, Fink, Foxe, Friedman, Fründ, Fujii, Fukatsu, García-Pérez, Ghacibeh, Goedert, Goldstein, Grady, Gregor Thut, Halligan, Halligan, Halligan, Harvey, Harvey, Hatin, Hausmann, Heber, Heber, Jenkins, Jewell, Kerkhoff, Kinsbourne, Klisz, Koch, Koch, Li, Logan, Longo, Loureiro, Luh, Lux, Manly, Marshall, Matthias, McCourt, McCourt, McCourt, Mennemeier, Milner, Milner, Milner, Monaghan, Monaghan, Monika Harvey, Morgan, Nagamatsu, Nebes, Newman, Nielson, Olk, O’Connell, Posner, Raz, Reuter-Lorenz, Reuter-Lorenz, Reuter-Lorenz, Reuter-Lorenz, Reuter-Lorenz, Ricci, Robinson, Rossi, Rueckert, Rueckert, Schmitz, Schmitz, Schneider, Solé-Padullés, Sowell, Stam, Sullivan, Szczepanski, Thiebaut de Schotten, Thiebaut de Schotten, Thomas, Toraldo, Urbanski, Vallar, Varnava, Varnava, Veronelli, Voyer, Waberski, Çiçek   +125 more
core   +4 more sources

Scoping review on the use of socially assistive robot technology in elderly care

BMJ Open, 2018
Objective With an elderly population that is set to more than double by 2050 worldwide, there will be an increased demand for elderly care. This poses several impediments in the delivery of high-quality health and social care.
Jordan Abdi, A. Al-Hindawi, Tiffany Ng, M. Vizcaychipi   +3 more
semanticscholar   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source