Results 41 to 50 of about 5,454,030 (357)

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

open access: yesFEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu   +17 more
wiley   +1 more source

Sentimentality and Nostalgia in Elderly People in Bulgaria and Greece – Cross-Validity of the Questionnaire SNEP and Cross-Cultural Comparison

open access: yesEurope's Journal of Psychology, 2017
Sentimentality and nostalgia are two similar psychological constructs, which play an important role in the emotional lives of elderly people who are usually focused on the past. There are two objectives of this study - making cross-cultural comparison of
Stanislava Yordanova Stoyanova   +2 more
doaj   +1 more source

The vulnerability of rural elderly Indonesian people to disability: an analysis of the national socioeconomic survey

open access: yesRural and Remote Health, 2021
Introduction: There is a high prevalence of elderly people aged 65 years and older with disabilities in low- and middle-income countries, including Indonesia. This study examined urban-rural disparities in disabilities among elderly Indonesian people by
Mardiana Puspitasari   +3 more
doaj   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

open access: yesFEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican   +7 more
wiley   +1 more source

Aging and quality of life of elderly people in rural areas.

open access: yesRevista Brasileira de Enfermagem, 2018
OBJECTIVE To evaluate the quality of life and health of elderly in rural areas of Minas Gerais State's center-west. METHOD Cross-sectional study, in four municipalities of Minas Gerais State, by interviewing elderly people.
Juliana Ladeira Garbaccio   +3 more
semanticscholar   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

open access: yesFEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer   +7 more
wiley   +1 more source

Preventing fractures in elderly people [PDF]

open access: yesBMJ, 2003
Preventing fractures in elderly people is a priority, especially as it has been predicted that in 20 years almost a quarter of people in Europe will be aged over 65. This article describes the factors contributing to fracture, interventions to prevent fracture, and the various treatments.
Woolf, Anthony D, Åkesson, Kristina
openaire   +4 more sources

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

open access: yesMolecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti   +10 more
wiley   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

open access: yesMolecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi   +12 more
wiley   +1 more source

ANALISIS KUNJUNGAN LANSIA DALAM KEGIATAN POSYANDU DI WILAYAH KERJA PUSKESMAS PINTU LANGIT KEC. PADANGSIDIMPUAN ANGKOLA JULU KOTA PADANGSIDIMPUAN TAHUN 2019

open access: yesJUMANTIK (Jurnal Ilmiah Penelitian Kesehatan), 2020
Overcoming a variety of health problems for the elderly, the government has made various health care policies for elderly people, one of them is the posyandu for the elderly.
Betti Agustina Nasution   +2 more
doaj   +1 more source

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