Results 31 to 40 of about 40,393 (210)

Unveiling Endotypes in Systemic Lupus Erythematosus Through Multi‐Omic Analysis: Insights into Cardiovascular and Renal Complications

open access: yesArthritis &Rheumatology, Accepted Article.
Background Systemic lupus erythematosus (SLE) shows clinical and molecular heterogeneity, and cardiovascular (CV) complications and lupus nephritis (LN) remain leading causes of morbidity and mortality. This study investigated whether omic profiling can reveal molecular endotypes linked to these outcomes.
Tomás Cerdó   +84 more
wiley   +1 more source

She Was One Of Us: Eleanor Roosevelt and the American Worker [PDF]

open access: yes, 2010
{Excerpt} For Eleanor Roosevelt, helping people achieve better lives by taking individual responsibility and then acting collectively to remedy problems was a cornerstone of democracy, in good and bad economic times, during war and peace.
O\u27Farrell, Brigid
core   +1 more source

Adolescents' trajectories of mental health in the MYRIAD trial

open access: yesJCPP Advances, EarlyView.
Abstract Background This study explored adolescent's mental health trajectories over the course of a school‐based mindfulness‐based intervention trial (MYRIAD). It examined whether intervention condition (mindfulness vs. teaching‐as‐usual), individual‐level and contextual‐level factors were associated with different trajectories.
Carolina Guzman Holst   +8 more
wiley   +1 more source

Dysregulation of Rac or Rho elicits death of motor neurons and activation of these GTPases is altered in the G93A mutant hSOD1 mouse model of amyotrophic lateral sclerosis

open access: yesNeurobiology of Disease, 2020
Rho GTPases play a central role in neuronal survival; however, the antagonistic relationship between Rac and Rho in the regulation of motor neuron survival remains poorly defined.
Trisha R. Stankiewicz   +3 more
doaj   +1 more source

SJSU ERFA News, Spring 2018 [PDF]

open access: yes, 2018
Volume 31, Number
San Jose State University, Emeritus and Retired Faculty Association
core   +1 more source

Genome‐Wide Assessment Reveals Ancestral Differences in Homozygosity Patterns Potentially Linked to Parkinson's Disease Etiology

open access: yesMovement Disorders, EarlyView.
Abstract Background Recessive genetic variation and extended runs of homozygosity (ROHs) may contribute to the unexplained heritability of Parkinson's disease (PD), particularly in diverse and understudied populations. Objective We conducted the first large‐scale, multi‐ancestral investigation of PD to examine the impact of genome‐wide homozygosity on ...
Kathryn Step   +680 more
wiley   +1 more source

Great Leaders Fight for the Right Cause at the Wrong Time [PDF]

open access: yes, 2014
Emilio Iodice examines a wealth of historical figures with the primary object of demonstrating how passion, commitment, and accountability are infused in the sayings and actions of great men and women; it is through their courage and sacrifice that we ...
Iodice, Emilio F.
core   +1 more source

The United Nations and the Human Rights Issue [PDF]

open access: yes, 1979
This paper demonstrates a new class of bugs that is likely to occur in enterprise OpenFlow deployments. In particular, step-by-step, reactive establishment of paths can cause network-wide inconsistencies or performance- and space-related inefficiencies ...
Canini, Marco   +5 more
core   +4 more sources

Small Airways Dysfunction and Remission in Adults With Asthma: A Longitudinal Exploratory Analysis of the AssessmenT of smalL Airways involvemeNT In aSthma (ATLANTIS) Study

open access: yesAllergy, EarlyView.
We conducted a post hoc analysis of ATLANTIS, a multinational prospective study including 684 adults with asthma. Fewer small airway symptoms and lower disease activity are independently associated with asthma remission. Replicated airway transcriptomic signatures show increased IL‐4/13 signalling and reduced coagulation pathways across the ATLANTIS ...
Akshi Kumar   +14 more
wiley   +1 more source

The CRISPR-Cas9 crADSL HeLa transcriptome: A first step in establishing a model for ADSL deficiency and SAICAR accumulation

open access: yesMolecular Genetics and Metabolism Reports, 2019
Adenylosuccinate lyase (ADSL) catalyzes two steps in de novo purine synthesis (DNPS). Mutations in ADSL can result in inborn errors of metabolism characterized by developmental delay and disorder phenotypes, with no effective treatment options. Recently,
Randall C. Mazzarino   +6 more
doaj   +1 more source

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