Results 11 to 20 of about 89,808 (272)

Real-time optical manipulation of cardiac conduction in intact hearts [PDF]

, 2018
Optogenetics has provided new insights in cardiovascular research, leading to new methods for cardiac pacing, resynchronization therapy and cardioversion.
Bocchi, L., Bub, G., Campione, M., Cannazzaro, S., Cerbai, E., Coppini, R., Crocini, C., Ferrantini, C., Giulietti, D., Loew, L.M., Margoni, E., Muellenbroich, C., Pavone, F.S., Poggesi, C., Sacconi, L., Scardigli, M., Yan, P.   +16 more
core   +2 more sources

Connexin diversity in the heart: insights from transgenic mouse models

Frontiers in Pharmacology, 2013
Cardiac conduction is mediated by gap junction channels that are formed by connexin (Cx) protein subunits. The connexin family of proteins consists of 24 members, varying in their biophysical properties and ability to combine with other connexins into ...
Sander eVerheule, Sven eKaese
doaj   +1 more source

Anatomic-electrophysiological correlations concerning the pathways for atrioventricular conduction. [PDF]

, 2001
The remarkable success of radiofrequency ablation in recent decades in curing atrioventricular nodal reentrant tachycardias has intensified efforts to provide a solid theoretical basis for understanding the mechanisms of atrioventricular transmission ...
Anderson, RH, Ho, SY, Mazgalev, TN
core   +1 more source

Advances and Prospects in Understanding Vertebrate Cardiac Conduction System, Pacemaker Cell, and Cardiac Muscle Development: Toward Novel Biological Therapies

Muscles, 2023
The heart is composed of muscle cells called cardiomyocytes, including a specialized population named pacemaker cells that form the cardiac conduction system (CCS), which is responsible for generating the action potential dictating heart contractions ...
Ridwan Opeyemi Bello, Shannon Frew, Yusra Siddiqui, Rashid Minhas   +3 more
doaj   +1 more source

Newly identified NO-sensor guanylyl cyclase/connexin 43 association is involved in cardiac electrical function [PDF]

, 2017
Background: Guanylyl cyclase, a heme-containing alpha 1 beta 1 heterodimer (GC1), produces cGMP in response to Nitric oxide (NO) stimulation. The NO-GC1-cGMP pathway negatively regulates cardiomyocyte contractility and protects against cardiac ...
Beuve, Annie, Brouckaert, Peter, Crassous, Pierre-Antoine, Gordan, Richard, Huang, Can, Lampe, Paul D, Shu, Ping, Xie, Lai-Hua   +7 more
core   +2 more sources

Restoring heart function and electrical integrity: closing the circuit

npj Regenerative Medicine, 2017
Cardiovascular diseases are the main cause of death in the world and are often associated with the occurrence of arrhythmias due to disruption of myocardial electrical integrity.
Luís Miguel Monteiro, Francisco Vasques-Nóvoa, Lino Ferreira, Perpétua Pinto-do-Ó, Diana Santos Nascimento   +4 more
doaj   +1 more source

Emerging from the Darkness. Sudden Cardiac Death in Cardiac Amyloidosis

Reviews in Cardiovascular Medicine, 2022
Cardiac amyloidosis (CA) manifests as infiltrative cardiomyopathy with a hypertrophic pattern, usually presenting with heart failure with a preserved ejection fraction. In addition, degenerative valvular heart disease, particularly severe aortic stenosis,
Valeria Cammalleri, Valeria Maria De Luca, Giorgio Antonelli, Ombretta Annibali, Annunziata Nusca, Simona Mega, Myriam Carpenito, Danilo Ricciardi, Fiorella Gurrieri, Giuseppe Avvisati, Gian Paolo Ussia, Francesco Grigioni   +11 more
doaj   +1 more source

Numerical simulation of electrocardiograms for full cardiac cycles in healthy and pathological conditions [PDF]

, 2015
This work is dedicated to the simulation of full cycles of the electrical activity of the heart and the corresponding body surface potential. The model is based on a realistic torso and heart anatomy, including ventricles and atria.
Bayés de Luna, Bayés de Luna, Beinart, Bishop, Boulakia, Boulakia, Boulakia, Bourgault, Bueno-Orovio, Buist, Chapelle, Chapelle, Chatterjee, Cohen, Collin, Corrado, Courtemanche, Deng, Ennis, Geuzaine, Harrild, Ho, Ho, Hoekema, Hudsmith, Huiskamp, Huiskamp, Hurtadoa, Jiamsripong, Jiang, Johnson, Keller, Krishnamoorthi, Krueger, Krueger, Lines, Liu, Malmivuo, Martin, Martini, Matsuo, McGuire, Mitchell, Nash, Netter, Nielsen, Ormiston, Potse, Potse, Pullan, Rosner, Sachse, Sovilj, Streeter, Sundnes, Sundnes, Trudel, Wang, Wartak, Wei, Yan, Zwink   +61 more
core   +5 more sources

Erbb2 is required for cardiac atrial electrical activity during development.

PLoS ONE, 2014
The heart is the first organ required to function during embryonic development and is absolutely necessary for embryo survival. Cardiac activity is dependent on both the sinoatrial node (SAN), which is the pacemaker of heart's electrical activity, and ...
Gennadiy Tenin, Christopher Clowes, Kathryn Wolton, Eliska Krejci, Jayne A Wright, Simon C Lovell, David Sedmera, Kathryn E Hentges   +7 more
doaj   +1 more source

Syncytium calcium signaling and macrophage function in the heart

Cell & Bioscience, 2018
Macrophages are traditionally viewed as a key component of the immunity defense system. Recent studies have identified resident macrophages in multiple organs including the heart, in which the cells perform their crucial role on tissue repair after ...
Xin Zhou, Zhongguang Li, Zefan Wang, Eda Chen, Juan Wang, Frederic Chen, Odell Jones, Tao Tan, Shawn Chen, Hiroshi Takeshima, Joseph Bryant, Jianjie Ma, Xuehong Xu   +12 more
doaj   +1 more source