Results 101 to 110 of about 5,808,571 (280)

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

TRAIP Mediates Alcohol‐Induced Liver Injury through Regulating β‐catenin Ubiquitin Degradation via Direct Interaction

Advanced Science, EarlyView.
This study reveals that NF‐κB1‐driven TRAIP upregulation in ALD correlates with disease severity. Mechanistically, TRAIP directly binds β‐catenin via its CC domain and promotes its K48‐linked ubiquitination and degradation, which is independent of the GSK3β/β‐TrCP pathway.
Zhan Wu, Mingjiang Liu, Lijuan Liao, Zhaohong Mo, Wenli Xu, Linfeng Mao, Yubing Chen, Qiuli Xie, Ming Yao, Shilian Chen, Stephen Tomlinson, Sebastian Mueller, Songqing He, Guandou Yuan   +13 more
wiley   +1 more source

Free thiol (SH) content (nmole/mg protein) of longissimus lumborum muscle during postmortem aging periods in goats subjected to slaughter without stunning and slaughter following different methods of electrical stunning (mean ± SE, n = 8).

, 2016
Free thiol (SH) content (nmole/mg protein) of longissimus lumborum muscle during postmortem aging periods in goats subjected to slaughter without stunning and slaughter following different methods of electrical stunning (mean ± SE, n = 8).
Mohd Zainal Abidin Ab Kadir (2586322), Awis Qurni Sazili (2586331), Ubedullah Kaka (2586334), Yong Meng Goh (2586316), Azad Behnan Sabow (2586310), Jurhamid Columbres Imlan (2586328), Ahmed Abubakar Abubakar (2586325), Idrus Zulkifli (2586313), Kazeem Dauda Adeyemi (2586319)   +8 more
core   +1 more source

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Effects of feed deprivation and electrical, gas and captive needle stunning on early postmortem muscle metabolism and subsequent meat quality

, 2002
The general method for stunning poultry before slaughter is by immersion of a chicken's head into an electrified waterbath. This method results in carcass and meat quality deficiencies.
Lambooij, E., Savenije, B, Lambooij, E, Gerritzen, MA, Korf, J., Schreurs, FJG, Savenije, B., Schreurs, F.J.G., Winkelman Goedhart, H.A., Korf, J, Gerritzen, M.A., Winkelman-Goedhart, HA   +11 more
core   +2 more sources

Malondialdehyde equivalents content (mg/kg) of longissimus lumborum muscle during postmortem aging periods in goats subjected to slaughter without stunning and slaughter following different methods of electrical stunning (mean ± SE, n = 8).

, 2016
Malondialdehyde equivalents content (mg/kg) of longissimus lumborum muscle during postmortem aging periods in goats subjected to slaughter without stunning and slaughter following different methods of electrical stunning (mean ± SE, n = 8).
Mohd Zainal Abidin Ab Kadir (2586322), Awis Qurni Sazili (2586331), Ubedullah Kaka (2586334), Yong Meng Goh (2586316), Azad Behnan Sabow (2586310), Jurhamid Columbres Imlan (2586328), Ahmed Abubakar Abubakar (2586325), Idrus Zulkifli (2586313), Kazeem Dauda Adeyemi (2586319)   +8 more
core   +1 more source

Concerted Action of Targeted Nucleic Acid Therapeutics as Flexible, Precision and Personalized Cancer Treatment

Advanced Science, EarlyView.
Combinations of small activating RNAs and small interfering RNAs were developed as personalized precision therapies that simultaneously activate tumor suppressors and silence oncogenes according to the molecular signatures of patient tumors. This combination strategy demonstrated superior anticancer efficacy, highlighting the promise of precision ...
Jing Wu, Jiaxuan Chen, Abdechakour Elkihel, Wenjun Lan, Nicolas Fraunhoffer, Dandan Zhu, Baoping Lian, Christina Galanakou, Zhancun Bian, Xi Liu, Odile Gayet, Loic Moubri, Julie Aglietti Roques, Vikash Reebye, Nagy Habib, Xiaoxuan Liu, Nelson Dusetti, Juan Lucio Iovanna, Ling Peng   +18 more
wiley   +1 more source

Carbonyl content (nmol/mg protein) of longissimus lumborum muscle during postmortem aging periods in goats subjected to slaughter without stunning and slaughter following different methods of electrical stunning (mean ± SE, n = 8).

, 2016
Carbonyl content (nmol/mg protein) of longissimus lumborum muscle during postmortem aging periods in goats subjected to slaughter without stunning and slaughter following different methods of electrical stunning (mean ± SE, n = 8).
Mohd Zainal Abidin Ab Kadir (2586322), Awis Qurni Sazili (2586331), Ubedullah Kaka (2586334), Yong Meng Goh (2586316), Azad Behnan Sabow (2586310), Jurhamid Columbres Imlan (2586328), Ahmed Abubakar Abubakar (2586325), Idrus Zulkifli (2586313), Kazeem Dauda Adeyemi (2586319)   +8 more
core   +1 more source