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Corrigendum to 'Electrochemotherapy for the treatment of basal cell tumours of the nasal planum in three cats'. [PDF]
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Mechanisms of electrochemotherapy
Advanced Drug Delivery Reviews, 1999Electrochemotherapy is a new therapeutic approach providing delivery into cell interiors of nonpermeant drugs with intracellular targets. It is based on the local application of short and intense electric pulses that transiently permeabilize cells in tissues. To date, its main application has been the treatment of tumor nodules when the electric pulses
, Mir, , Orlowski
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The Basis of Electrochemotherapy
2003Antitumor electrochemotherapy is a treatment of solid tumors which combines a cytotoxic nonpermeant drug, like bleomycin, with locally delivered permeabilizing electric pulses (1-3). More generally, a new form of vectorization is achieved by the combination of nonpermeant molecules with intracellular targets and of a physical perturbation that locally ...
L M, Mir, S, Orlowski
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Electrochemotherapy for digital chondrosarcoma
Journal of Orthopaedic Science, 2003Electrochemotherapy (ECT) delivers nonpermeable anticancer drugs to cell interiors by temporally increasing the permeability of the cytoplasmic membrane under locally applied pulsating electrical stimuli. This treatment results in consistent and enhanced pharmacological effects of drugs on the targeted tissue.
Tominaga Shimizu +8 more
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Clinical applications of electrochemotherapy
Advanced Drug Delivery Reviews, 1999Electrochemotherapy is a novel treatment which consists of a combination of a chemotherapeutic agent and pulsed electric fields. This relatively new treatment modality relies on the physical effects of locally applied electric fields to temporarily destabilize cell membranes in the presence of a drug to allow increased uptake of the agent into the ...
, Heller, , Gilbert, , Jaroszeski
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Utility of electrochemotherapy in melanoma treatment
Current Opinion in Oncology, 2012In the present study, the role of electrochemotherapy (ECT) in the advanced melanoma setting, either as alternative treatment modality to conventional therapies or as palliative care, is reviewed and the perspective to combine ECT with biological response modifiers and immunotherapeutic compounds is discussed.ECT refers to the combination of ...
Alessandro Testori +2 more
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Treatment of metastatic melanoma with electrochemotherapy
Journal of Surgical Oncology, 2013Superficially metastatic melanoma still represents a challenging situation for oncologists and a distressing condition for patients. In this circumstance, local treatment by electrochemotherapy, that is, the combination of brief permeabilizing electric pulses with a low‐toxicity anticancer drug, can be a valuable treatment option in selected patients ...
Luca G, Campana +3 more
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[Anaesthesia in Electrochemotherapy].
Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 2020Electrochemotherapy (ECT) is a symptom control method for inoperable or exulcerating cutaneous metastases or skin cancer. With the help of electroporation, an enhancement of the efficacy of the administered chemotherapeutic agent, bleomycin or cisplatin, is achieved, which leads to a local reduction of the metastases and thereby has a low impact on the
Christian, Volberg, Martin, Gschnell
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Novel electrode designs for electrochemotherapy
Biochimica et Biophysica Acta (BBA) - General Subjects, 1997Direct current pulses for electrochemotherapy treatment are typically administered using two parallel plate electrodes that are placed on either side of the tumor. This simple design has produced high response rates (70 to 85%) in animal studies and in clinical trials. However, parallel plate electrodes are not suitable for all situations.
R A, Gilbert, M J, Jaroszeski, R, Heller
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